Abstract:
:As a prevalent disease all over the world, changed functional activities and/or structures in many brain regions have been found in depression. In this study, 5-week chronic restraint stress (CRS) was performed to establish depression rat models, and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) was used to detect brain functional activities. Our study found that CRS induced depressive behaviors and increased the expression of serum IL-6. After exposure to CRS, rats showed decreased glucose metabolism in the whole-brain and brain regions including left medial prefrontal and auditory cortices; right amygdala, cingulate cortex, olfactory and AcbCore/Shell; bilateral caudate putamen, dorsal hippocampi, insular and entorhinal cortices. Expression of serum IL-6 and glucose metabolism in most of the above brain regions were significantly correlated with the severity of some CRS-induced depressive behaviors. In conclusion, the increased peripheral inflammatory response and decreased brain functional activities might be the important pathogenesis of experimental depression induced by CRS, and could reflect the severity of depression to some extent.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Wei K,Bao W,Zhao Z,Zhou W,Liu J,Wei Y,Li M,Wu X,Liu B,Du Y,Gong W,Dong Jdoi
10.1016/j.neulet.2017.11.047subject
Has Abstractpub_date
2018-02-05 00:00:00pages
104-109eissn
0304-3940issn
1872-7972pii
S0304-3940(17)30956-4journal_volume
665pub_type
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