Abstract:
:The opioid peptide dynorphin decreased somatic calcium-dependent action potential duration in a portion of mouse dorsal root ganglion (DRG) neurons without altering resting membrane potential or conductance. Dynorphin action was antagonized by naloxone. Responses of DRG neurons to dynorphin differed from responses to the opioid peptides leucine-enkephalin, which binds preferentially to delta-opiate receptors, and morphiceptin, which binds preferentially to mu-opiate receptors. Firstly, many DRG neurons responded to dynorphin but not to leucine-enkephalin or morphiceptin. Secondly, dynorphin responses, unlike leucine-enkephalin or morphiceptin responses, persisted following intracellular injection of cesium, a potassium channel blocker. We suggest that dynorphin acts at an opiate receptor distinct from mu- and delta-receptors and that this receptor is coupled to a voltage-dependent calcium channel.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Werz MA,Macdonald RLdoi
10.1016/0304-3940(84)90439-7subject
Has Abstractpub_date
1984-05-04 00:00:00pages
185-90issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(84)90439-7journal_volume
46pub_type
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