Abstract:
:Adenosine has been proposed to be a chemical link between cerebral metabolism and blood flow. In the present study, we investigated whether the intravenous or intracarotid administration of adenosine could influence regional cerebral blood flow in anesthetized rabbits. The study was performed with the [14C]ethanol tissue sampling technique which enables quantitative, instantaneous, multiregional blood flow measurements. With either mode of adenosine administration, no change in cerebral blood flow was observed, except in the caudate nucleus in which a significant vasodilation took place. These data indicate that, in rabbits exogenous adenosine increases blood flow in highly specific brain areas, by mechanisms that are discussed.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Puiroud S,Pinard E,Miller MC,Seylaz Jdoi
10.1016/0304-3940(87)90658-6subject
Has Abstractpub_date
1987-09-23 00:00:00pages
224-8issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(87)90658-6journal_volume
80pub_type
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