Abstract:
:The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings of six healthy volunteers to assess whether acute pain by itself causes a reorganization of the primary somatosensory cortex. After the induction of an intense experimental pain at the thenar of the left hand by intradermal injection of capsaicin, the extent of the cortical hand representation and the distance between the hand representation and the localization of the lip decreased. A likely mechanism for this acute reorganization is that pain induced hyperresponsiveness of the left thenar to tactile input from neighboring body sites.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sörös P,Knecht S,Bantel C,Imai T,Wüsten R,Pantev C,Lütkenhöner B,Bürkle H,Henningsen Hdoi
10.1016/s0304-3940(00)01752-3keywords:
subject
Has Abstractpub_date
2001-02-09 00:00:00pages
195-8issue
3eissn
0304-3940issn
1872-7972pii
S0304394000017523journal_volume
298pub_type
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