Abstract:
:Parkinson's disease is due to a dopamine deficiency caused by the degeneration of midbrain dopamine neurons. Current therapies are aimed to substitute dopamine or to directly stimulate postsynaptic dopamine receptors. However, not all patients profit from current therapies to the same extent, even serious side effects such as dyskinesias are complicating the therapy. Therefore, there is still a need for better anti-parkinsonian drugs. Here we show that some compounds from the 'Ecstasy'-derivatives exert potent anti-parkinsonian activity. 3,4-Methylenedioxymethamphetamine, 'Ecstasy' dose-dependently and very potently reversed haloperidol-induced parkinsonism in the rat. From the supraadditive effect of the enantiomers it may be concluded that both enantiomers contribute to the antiparkinsonian effects at two different target sites.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Schmidt WJ,Mayerhofer A,Meyer A,Kovar KAdoi
10.1016/s0304-3940(02)00823-6keywords:
subject
Has Abstractpub_date
2002-09-27 00:00:00pages
251-4issue
3eissn
0304-3940issn
1872-7972pii
S0304394002008236journal_volume
330pub_type
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