Ecstasy counteracts catalepsy in rats, an anti-parkinsonian effect?

Abstract:

:Parkinson's disease is due to a dopamine deficiency caused by the degeneration of midbrain dopamine neurons. Current therapies are aimed to substitute dopamine or to directly stimulate postsynaptic dopamine receptors. However, not all patients profit from current therapies to the same extent, even serious side effects such as dyskinesias are complicating the therapy. Therefore, there is still a need for better anti-parkinsonian drugs. Here we show that some compounds from the 'Ecstasy'-derivatives exert potent anti-parkinsonian activity. 3,4-Methylenedioxymethamphetamine, 'Ecstasy' dose-dependently and very potently reversed haloperidol-induced parkinsonism in the rat. From the supraadditive effect of the enantiomers it may be concluded that both enantiomers contribute to the antiparkinsonian effects at two different target sites.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Schmidt WJ,Mayerhofer A,Meyer A,Kovar KA

doi

10.1016/s0304-3940(02)00823-6

keywords:

subject

Has Abstract

pub_date

2002-09-27 00:00:00

pages

251-4

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394002008236

journal_volume

330

pub_type

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