Abstract:
:Oleamide is a recently described lipid, obtained from the cerebrospinal fluid of sleep-deprived cats. It has been observed that oleamide possesses several biological effects, such as sleep induction, and immunological suppression as well as serotonin and gamma-aminobutyric acid receptors activation. In addition, oleamide also binds to the cannabinoid receptors. In this study, we have observed that oleamide facilitates memory extinction in a passive avoidance paradigm, reduces core temperature and pain perception, but does not affect significantly locomotion. These results suggest that oleamide modulates memory processes. However, we do not know if oleamide impairs the retrieval of the memory associated to the "not go" behavior, or facilitates the fast re-learning of the "go" behavior. In addition, since these effects are also induced by marijuana and anandamide, it is very likely that oleamide may be affecting the cerebral cannabinoid system to induce its effects.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Murillo-Rodríguez E,Giordano M,Cabeza R,Henriksen SJ,Méndez Díaz M,Navarro L,Prospéro-García Odoi
10.1016/s0304-3940(01)02256-xkeywords:
subject
Has Abstractpub_date
2001-11-02 00:00:00pages
61-4issue
1-2eissn
0304-3940issn
1872-7972pii
S030439400102256Xjournal_volume
313pub_type
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