Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells.

Abstract:

:Calpain activity of nerve growth factor (NGF)-induced rat pheochromocytoma (PC12) cells shows a transient diminution in the early phase of differentiation. Calpain activity can be further decreased by a cell-permeable calpain inhibitor, calpeptin, which enhances the effect of NGF by stimulating neurite elongation. The number of neurites sprouted by one cell is not increased by calpeptin. A possible role of calpain inhibition during PC12 cells' early differentiation is discussed.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Pintér M,Aszódi A,Friedrich P,Ginzburg I

doi

10.1016/0304-3940(94)90246-1

subject

Has Abstract

pub_date

1994-03-28 00:00:00

pages

91-3

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(94)90246-1

journal_volume

170

pub_type

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