Abstract:
:A replication-defective recombinant adenoviral vector containing E. coli lacZ gene was injected into the gastrocnemius muscles of transgenic mice carrying mutant Cu/Zn superoxide dismutase (SOD1) gene and non-transgenic wild-type mice at 40 weeks of age. After 60 and 90 h of the injection, lacZ staining was observed at the distal ends of the sciatic nerves in both mice groups, with the number and the distances greatly reduced in the transgenic mice. Mean velocities of retrograde transport for lacZ was estimated to be 2.1 and 0.05 mm/24 h in non-transgenic and transgenic mice, respectively. These results indicate that the retrograde axonal transport of foreign gene product is impaired in the mice model for familial amyotrophic lateral sclerosis.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Murakami T,Nagano I,Hayashi T,Manabe Y,Shoji M,Setoguchi Y,Abe Kdoi
10.1016/s0304-3940(01)02036-5keywords:
subject
Has Abstractpub_date
2001-08-10 00:00:00pages
149-52issue
3eissn
0304-3940issn
1872-7972pii
S0304394001020365journal_volume
308pub_type
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journal_title:Neuroscience letters
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