Abstract：
:Changes in cytokine and chemokine expression during Wallerian degeneration have been studied using nerve transection models, which result in denervation of both myelinating and non-myelinating Schwann cells. Cytokine and chemokine response of non-myelinating Remak Schwann cells to loss of their axons is unknown. In this study, we compared the expression profile of various cytokines and chemokines in distal nerves after capsaicin-induced degeneration of unmyelinated axons to Wallerian degeneration induced by nerve transection. Upregulation of MCP-1, IL-2, IL-6 and IL-10 were seen in both groups but IL-1ss and LIF were primarily upregulated in Wallerian degeneration of the whole nerve and not in capsaicin-induced degeneration of unmyelinated axons. The activated macrophage response, as measured by an increase in ED-1 immunostaining, was more prominent in the transected sciatic nerves compared to capsaicin-treated nerves. These findings indicate that there are differences in the cytokine and chemokine response of myelinating and non-myelinating Schwann cells to loss of their axons, and add to a growing body of literature that points to greater heterogeneity among Schwann cells.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Cheepudomwit T,Güzelsu E,Zhou C,Griffin JW,Höke Adoi
10.1016/j.neulet.2007.11.003subject
Has Abstractpub_date
2008-01-17 00:00:00pages
230-5issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(07)01163-9journal_volume
430pub_type
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