Abstract:
:A major action of adenosine is the induction of profound behavioral inactivity. 6-(4-Nitrobenzyl)-thioinosine (NBI) and 6-(2-hydroxy-5-nitrobenzyl)-thioguanosine (NBG) have been shown to inhibit adenosine uptake. To investigate the possible synergism between exogenous ligand and reuptake inhibition, mice were treated with NBI or NBG + adenosine. NBI and NBG potentiated the effects of adenosine at doses which did not in themselves induce behavioral inactivity. These behavioral results support the proposed role of NBI and NBG as adenosine uptake site blockers which increase synaptic concentrations of adenosine and postsynaptic responses to adenosine in vivo.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Crawley JN,Patel J,Marangos PJdoi
10.1016/0304-3940(83)90260-4subject
Has Abstractpub_date
1983-04-11 00:00:00pages
169-74issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(83)90260-4journal_volume
36pub_type
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