Abstract:
:Exposure to alcohol in utero has been associated with hypothyroidism and a variety of developmental defects characteristic of thyroid dysfunction. The present work examined whether these abnormalities could be reversed in infant rats treated with thyroid hormones. Subjects were offspring of dams which were on the following diet regimen during gestation: (1) free access to liquid diet containing ethanol (alcohol pups); (2) an equal volume of isocaloric liquid diet (pair-fed pups); or (3) ad libitum control diet (control pups). Neonates from each group were foster-nursed by control dams, and received triiodothyronine (T3; 0.1 mg/kg/day; s.c.) or saline treatments on postnatal days 1 to 10. The alcohol neonates displayed reduced serum thyroxine which was restored to normal by postnatal day 14. In addition, these pups showed a delayed appearance of developmental landmarks, including righting reflex, dental eruption, auditory startle response and eye opening. The retarded incisor eruption and eye opening were reversed in alcohol pups by T3 treatments. The present data suggest that at least some of the developmental abnormalities associated with prenatal alcohol exposure are attributable to perinatal hypothyroidism and can be restored by early hormone replacement therapy.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Gottesfeld Z,Silverman PBdoi
10.1016/0304-3940(90)90535-hsubject
Has Abstractpub_date
1990-02-05 00:00:00pages
42-7issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(90)90535-Hjournal_volume
109pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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