Abstract：
:Brain content of leucine-enkephalin and methionine-enkephalin changes independently during kindling of the amygdala. Both peptides were measured after 4, 8, 15 and 21 days of stimulation. Leu-enkephalin showed a progressive increase during the kindling: the results on the 4th day did not differ significantly from the controls, whereas those on the 8th day displayed an increase only in the stimulated left hemisphere and those on the 15th day showed an increase in both hemispheres. This increase was also seen after 21 days of stimulation. In contrast, Met-enkephalin was not modified during the early stages of kindling, but was found to be increased after the animals had presented five or more generalized seizures. These results show that Leu-enkephalin is related to the development of kindling, whereas Met-enkephalin levels change only as a consequence of the generalized seizures.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Vindrola O,Briones R,Asai M,Fernández-Guardiola Adoi
10.1016/0304-3940(81)90337-2subject
Has Abstractpub_date
1981-10-23 00:00:00pages
125-30issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(81)90337-2journal_volume
26pub_type
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