Demonstration of amyloid beta-protein secretion in a mouse neuronal cell line.

abstract：:The development of supersensitivity to dopamine by striatal neurons is widely considered to be a response to interruption of dopaminergic synaptic function. However, it is not clear whether pre-existing dopaminergic innervation is in fact necessary for supersensitivity to develop. In this study, rat foetal striatal ce...

journal_title：Neuroscience letters

authors： Guerra MJ,Liste I,Rozas G,Tobio J,Labandeira-Garcia JL

更新日期：1996-03-15 00:00:00

abstract：:In this study we examined the presence of dopamine D1 receptors in monkey amniotic epithelial cells (MAEC) using RT-PCR and radioligand binding experiments. We found that MAEC express D1 receptor mRNA that is having 99% homology with human dopamine D1 receptors. Saturation binding studies using [3H]SCH-23390 showed a ...

journal_title：Neuroscience letters

authors： Elwan MA,Ishii T,Ono F,Sakuragawa N

更新日期：1999-02-26 00:00:00

abstract：:To assess the role of nasal/tracheal (N/T) breathing in the respiratory patterning of the olfactory bulb (OB) neurons, the activity of 21 units was recorded in 6 anesthetized rats set with a cannula enabling reversible tracheotomy: the rats could inhalate either through nasal pathways or through trachea directly. Shif...

journal_title：Neuroscience letters

authors： Ravel N,Pager J

更新日期：1990-07-31 00:00:00

abstract：:Our previous study has shown that both electroacupuncture (EA) and vagus nerve stimulation (VNS) can inhibit cortical epileptiform activities induced by pentylenetetrazole (PTZ). The current study compared the effects of EA and VNS on thalamic neuronal responses to PTZ-induced epileptiform activities. Under general an...

journal_title：Neuroscience letters

authors： Zhang JL,Zhang SP,Zhang HQ

更新日期：2008-08-22 00:00:00

abstract：:Deposition of amyloid beta (A beta) is one of the pathological hallmarks of brains affected with Alzheimer's disease (AD). The accumulation of A beta have been observed in human myopathies with rimmed vacuoles (RVs) which might involve lysosomal function. Chloroquine, a potent lysosomotropic agent, induces muscle path...

journal_title：Neuroscience letters

authors： Tsuzuki K,Fukatsu R,Takamaru Y,Kimura K,Abe M,Shima K,Fujii N,Takahata N

更新日期：1994-12-05 00:00:00

abstract：:Previous neuroimaging studies raised the hypothesis that enhanced activity in the ipsilateral motor cortex (M1) plays a contributing role in the compensation for the motor deficits resulting from a spinal cord injury (SCI). However, it is still unknown whether the activity in the ipsilateral M1 directly contributes to...

journal_title：Neuroscience letters

authors： Nardone R,Höller Y,Höller P,Thon N,Thomschewski A,Brigo F,Trinka E

更新日期：2013-09-27 00:00:00

abstract：:Traumatic brain injury (TBI) represents a major cause of long-term disability worldwide. Primary damage to brain tissue leads to complex secondary injury mechanisms involving inflammation, oxidative stress and cellular activation/reactivity. The molecular pathways that exacerbate brain cell dysfunction after injury ar...

journal_title：Neuroscience letters

authors： Hlavac N,Guilhaume-Corrêa F,VandeVord PJ

更新日期：2020-11-20 00:00:00

abstract：:Crickets (Gryllus bimaculatus) use the cercal sensory system at the rear of the abdomen to detect air currents and direct predator avoidance behavior. Sensory information regarding the direction and dynamic properties of air currents is processed within the terminal abdominal ganglion, and conveyed by ascending giant ...

journal_title：Neuroscience letters

authors： Ogawa H,Kajita Y

更新日期：2015-01-01 00:00:00

abstract：:Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801)...

journal_title：Neuroscience letters

authors： Dragunow M,Beilharz E,Mason B,Lawlor P,Abraham W,Gluckman P

更新日期：1993-10-01 00:00:00

abstract：:P2X receptors (P2XRs) are a family of ATP-gated ionic channels that are expressed in numerous excitable and non-excitable cells. Despite the great advance on the structure and function of these receptors in the last decades, there is still lack of specific and potent antagonists for P2XRs subtypes, especially for the ...

journal_title：Neuroscience letters

authors： Coddou C,Sandoval R,Hevia MJ,Stojilkovic SS

更新日期：2019-01-18 00:00:00

abstract：:The pathogens of Alzheimer's disease (AD) are still unclear, while accumulating evidences have indicated that both genetic and environmental factors are involved in the pathogenesis of AD. Recent studies suggest that AD is primarily a vascular disorder and copper (Cu) may play an important role in AD pathology. Howeve...

journal_title：Neuroscience letters

authors： Mao X,Ye J,Zhou S,Pi R,Dou J,Zang L,Chen X,Chao X,Li W,Liu M,Liu P

更新日期：2012-06-14 00:00:00

abstract：:Ideomotor theory states that the neural codes that represent action and the perceptual consequences of those actions are tightly bound in a common code. For action imagination, bound action, and perceptual codes are thought to be internally activated at a sub-threshold level through action simulation. In support of th...

journal_title：Neuroscience letters

authors： Yoxon E,Tremblay L,Welsh TN

更新日期：2015-01-12 00:00:00

abstract：:It is known that 5HTR2A (rs6311) receptors have high concentration in the cortical layer-5 pyramidal neurons and that these receptors play an important role in the modulation of neurocognitive functions. For example, layer-5 pyramidal neurons mediate cellular level integrative interaction of primary sensory afferent s...

journal_title：Neuroscience letters

authors： Maksimov M,Vaht M,Harro J,Bachmann T

更新日期：2015-01-01 00:00:00

abstract：:Galantamine, which is currently used in the treatment of patients with Alzheimer's disease (AD), has been shown to have a neuroprotective effect against beta-amyloid (Abeta) peptide-induced toxicity, which is involved in the pathogenesis of AD. In this study, we investigated the mechanism underlying the protective eff...

journal_title：Neuroscience letters

authors： Li Q,Fang J,Yang M,Wu D,Zhang L,Zhang Y

更新日期：2010-08-23 00:00:00

abstract：:Various tracer substances were injected into the spinal cord, the dorsal column nuclei, the trigeminal nuclear complex and the somatosensory cortex in Madagascan hedgehog tenrecs. With the exception of the cases injected exclusively into the spinal cord all injections gave rise to sparse, but distinct anterograde proj...

journal_title：Neuroscience letters

authors： Wolff A,Künzle H

更新日期：1997-01-17 00:00:00

abstract：:Changes in the activity of gamma-glutamyl transpeptidase (GGTP) and the effects of a subacute dose (150 mg/kg b.wt.) of methionine sulfoximine (MSO) on its activity were studied in cerebral cortex, cerebellum and brainstem of rats of 4 different age groups. GGTP activity increased with increasing age between days 10 a...

journal_title：Neuroscience letters

authors： Rao VL,Murthy CR

更新日期：1991-05-13 00:00:00

abstract：:Following ventral root injury-filling with horseradish peroxidase at sacral spinal levels S1, S2, and S3, small fascicles of axons can be observed to enter the ventral portion of lamina I and arborize primarily in the dorsolateral region just medial to the tract of Lissauer (TL). Some axons enter the TL and turn in a ...

journal_title：Neuroscience letters

authors： Beattie MS,Bresnahan JC,Mawe GM,Finn S

更新日期：1987-04-23 00:00:00

abstract：:The regional cerebral blood flow (rCBF) was measured with positron emission tomography in eight normal volunteers with the purpose of measuring rCBF changes related to the comprehension of an unfamiliar spoken languages. When attempting to comprehend the meaning of words, the left hemisphere showed dominant increases ...

journal_title：Neuroscience letters

authors： Kawashima R,Itoh M,Hatazawa J,Miyazawa H,Yamada K,Matsuzawa T,Fukuda H

更新日期：1993-10-14 00:00:00

abstract：:Tapentadol is a dual action molecule with mu opioid agonist and norepinephrine (NE) reuptake blocking activity that has recently been introduced for the treatment of moderate to severe pain. The effects of intraperitoneal (i.p.) morphine (10mg/kg), tapentadol (10 or 30 mg/kg) or duloxetine (30 mg/kg), a norepinephrine...

journal_title：Neuroscience letters

authors： Meske DS,Xie JY,Oyarzo J,Badghisi H,Ossipov MH,Porreca F

更新日期：2014-03-06 00:00:00

abstract：:The extent to which N-Methyl-d-aspartate (NMDA) receptors facilitate the motivation to voluntarily wheel-run in rodents has yet to be determined. In so, we utilized female Wistar rats selectively bred to voluntarily run high (HVR) and low (LVR) nightly distances in order to examine if endogenous differences in nucleus...

journal_title：Neuroscience letters

authors： Grigsby KB,Kovarik CM,Rottinghaus GE,Booth FW

更新日期：2018-04-03 00:00:00

abstract：:Supporting cell mitosis contributes significantly to hair cell regeneration in the acoustically damaged bird inner ear. Yet there may be another mechanism of hair cell replacement: supporting cell conversion. This study used cytosine arabinoside (Ara-C), an inhibitor of DNA synthesis, to better determine whether suppo...

journal_title：Neuroscience letters

authors： Adler HJ,Raphael Y

更新日期：1996-02-16 00:00:00

abstract：:Immunoelectron microscopy combined with a retrograde tracing technique was carried out to examine the synaptic interaction between neuropeptide Y (NPY)-like immunoreactive (LI) axon terminals and spinal motoneurons innervating bulbocavernosus muscles. Cell bodies and proximal dendrites of these motoneurons were freque...

journal_title：Neuroscience letters

authors： Kawano M,Sugita O,Inagaki S,Furuyama T,Takagi H

更新日期：1993-04-02 00:00:00

abstract：:Cellular origins of methylarginines are not precisely known but the presence of free methyl and dimethylarginines in the brain were reported. We have investigated the circulating concentrations of asymmetrical dimethylarginine NG,NG-dimethylarginine (ADMA), NG,NG-dimethylarginine (SDMA), nitrate and nitrite levels in ...

journal_title：Neuroscience letters

authors： Das I,Khan NS,Puri BK,Hirsch SR

更新日期：1996-09-13 00:00:00

abstract：:Gene expression can be regulated by chromatin remodeling induced by the opposing actions of histone acetyltransferases and histone deacetylases (HDAC). HDAC inhibitors are considered putative anti-cancer drugs, but may also alter gene expression in the brain. Valproic acid (valproate; VPA), a drug used for treatment o...

journal_title：Neuroscience letters

authors： Yildirim E,Zhang Z,Uz T,Chen CQ,Manev R,Manev H

更新日期：2003-07-17 00:00:00

abstract：:Parkinson's disease (PD) is defined as a chronic neurodegenerative disorder which is diagnosed mostly by its clinical manifestations. Reactive oxygen species (ROS) are considered as key modulators in the development of PD. Despite the intensive investigations, antioxidant-dependent molecular mechanisms of initiation a...

journal_title：Neuroscience letters

authors： Hemmati-Dinarvand M,Saedi S,Valilo M,Kalantary-Charvadeh A,Alizadeh Sani M,Kargar R,Safari H,Samadi N

更新日期：2019-09-14 00:00:00

abstract：:One of the clinical characteristics of psychogenic tremors (PT) is the disruption or transient cessation of tremor with distractive manoeuvres, including those involving the performance of voluntary movements with the contralateral hand. Seven patients with PT, 11 patients with Parkinson's disease (PD), 10 patients wi...

journal_title：Neuroscience letters

authors： Kumru H,Valls-Solé J,Valldeoriola F,Marti MJ,Sanegre MT,Tolosa E

更新日期：2004-11-11 00:00:00

abstract：:The cardiovascular effects of intracerebroventricularly administered thyrotropin-releasing hormone (TRH) were studied in anesthetized rats in the presence of serotonin (5-HT) depletion induced by pretreatments with p-chloroamphetamine (PCA) or p-chlorophenylalanine (PCPA). After PCA the reduction of the whole brain 5-...

journal_title：Neuroscience letters

authors： Nurminen ML,Paakkari I,Seppälä T

更新日期：1991-06-24 00:00:00

abstract：:It is well known that acetyl-l-carnitine (ALC) has various neuroprotective effects against neurodegenerative diseases. In addition, it has been reported that ALC facilitates myelination of regenerated axons after peripheral nerve injuries. We previously reported that spontaneous regeneration of the lateral olfactory t...

journal_title：Neuroscience letters

authors： Fukushima N,Yokouchi K,Kuroiwa M,Kawagishi K,Moriizumi T

更新日期：2017-07-13 00:00:00

abstract：:The content of the neurosteroids, dehydroepiandrosterone (DHEA) in the brain decreases with aging. Also the oxidative energy metabolism is known to decrease with aging. Hence we examined the effects of treatment with DHEA (0.2 or 1.0 mg/kg body weight for 7 days) on oxidative energy metabolism in brain mitochondria fr...

journal_title：Neuroscience letters

authors： Patel MA,Katyare SS

更新日期：2006-07-10 00:00:00

abstract：:Novel retinal pigment epithelial cell gene (Norpeg, Rai14), a developmentally regulated mouse gene, encodes a protein containing six ankyrin repeats and a coiled-coil domain. The objective of the present study was to characterize the Norpeg protein and to analyze its expression in mouse retina using an antibody prepar...

journal_title：Neuroscience letters

authors： Kutty RK,Samuel W,Chen S,Vijayasarathy C,Dun Y,Mysona B,Wiggert B,Smith SB

更新日期：2006-09-01 00:00:00