Abstract:
:Gene expression can be regulated by chromatin remodeling induced by the opposing actions of histone acetyltransferases and histone deacetylases (HDAC). HDAC inhibitors are considered putative anti-cancer drugs, but may also alter gene expression in the brain. Valproic acid (valproate; VPA), a drug used for treatment of bipolar disorder, has been characterized as a HDAC inhibitor. In neuronal cultures, VPA increases the expression of 5-lipoxygenase (5-LOX). Here we show that in vivo treatment of mice with intraperitoneal VPA injections increases the acetylation of histone H3 and the content of 5-LOX immunoreactive protein in the hippocampus. Since the extent of 5-LOX expression may alter mouse behavior, we suggest that VPA-altered chromatin remodeling and 5-LOX expression in the brain may be functionally important.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Yildirim E,Zhang Z,Uz T,Chen CQ,Manev R,Manev Hdoi
10.1016/s0304-3940(03)00490-7keywords:
subject
Has Abstractpub_date
2003-07-17 00:00:00pages
141-3issue
2eissn
0304-3940issn
1872-7972pii
S0304394003004907journal_volume
345pub_type
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