Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia.

abstract：:Alpha-2 macroglobulin (encoded by the gene A2M) is a serum pan-protease inhibitor that may be related with the pathogenesis of Alzheimer's disease (AD) because of its ability to mediate amyloid beta degradation. Recently, several groups have reported that the five-nucleotides deletion in A2M gene at the 5' splice site...

journal_title：Neuroscience letters

authors： Shibata N,Ohnuma T,Takahashi T,Ohtsuka E,Ueki A,Arai H

更新日期：1999-08-20 00:00:00

abstract：:Reduced supply of glucose involves in many pathological conditions such as stroke and contributes to ischemic injuries. In contrast, hyperglycemia has also been regarded as an important factor in causing and exaggerating stroke damage. Although the molecular mechanism(s) of imbalanced glucose-induced cellular injuries...

journal_title：Neuroscience letters

authors： Shi H,Liu KJ

更新日期：2006-12-13 00:00:00

abstract：:ATP is an important extracellular messenger in the CNS. In the hippocampus, a brain structure relevant for learning and memory processes, it acts both as a modulator and as a mediator of synaptic transmission, with implications for synaptic plasticity phenomena. Recent evidence suggests that ATP modulates activity-dep...

journal_title：Neuroscience letters

authors： da Silva BM,de Mendonça A,Ribeiro JA

更新日期：2005-08-05 00:00:00

abstract：:Evidence suggests that high peripheral beta-amyloid (Abeta)(1-40) levels and low ratios of Abeta(1-42)/Abeta(1-40) are associated with increased risk for Alzheimer's disease (AD). In this cross-sectional design, serum and plasma samples from 67 AD patients and 146 controls (similar in age and gender) were evaluated us...

journal_title：Neuroscience letters

authors： Abdullah L,Paris D,Luis C,Quadros A,Parrish J,Valdes L,Keegan AP,Mathura V,Crawford F,Mullan M

更新日期：2007-11-27 00:00:00

abstract：:Morphine analgesia measured by the tail withdrawal test was examined in rats that were either restrained or left free during testing. It was found that restraint potentiated morphine analgesia and decreased the latency of the peak analgesic effect. Methysergide, a serotonin antagonist, and valine, which prevents the i...

journal_title：Neuroscience letters

authors： Kelly SJ,Franklin KB

更新日期：1984-02-24 00:00:00

abstract：:Evidence indicates that sympathetic nerves and substance P (SP) are involved in some physiological and pathophysiological changes and activities in retina. The aim of this study was to investigate whether SP participates in the stress reaction and possible involvement of adrenergic mechanisms in modulation of the chan...

journal_title：Neuroscience letters

authors： Yang JH,Meng XX,Xie LS,Guo Z

更新日期：2008-10-10 00:00:00

abstract：:Infarct volume and immunoreactivities for trkB and trkC in rat brain were compared at 24 h after 90 min of transient middle cerebral artery occlusion (MCAO) between animal groups with or without neurotrophin-3 (NT-3, 10 microg/250 g animal). Treatment of rat brain with topical application of NT-3 significantly reduced...

journal_title：Neuroscience letters

authors： Zhang WR,Hayashi T,Wang JM,Sasaki C,Sakai K,Warita H,Shiro Y,Suenaga H,Ohmae H,Tsuji S,Itoh T,Nishimura O,Nagasaki H,Abe K

更新日期：1999-12-10 00:00:00

abstract：:Microelectrode recordings from the somata of rat dorsal root ganglion (DRG) cells were used to correlate their electrophysiological characteristics with sensitivity to locally applied capsaicin. Of the 80 cells tested, 17 responded to capsaicin by a rapid depolarization. These cells had low axonal conduction velocitie...

journal_title：Neuroscience letters

authors： Heyman I,Rang HP

更新日期：1985-05-01 00:00:00

abstract：:The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol dose all other indole...

journal_title：Neuroscience letters

authors： Prevedello MR,Ritta MN,Cardinali DP

更新日期：1979-06-01 00:00:00

abstract：:Neurons within the hypothalamic paraventricular nuclei (PVN) have been antidromically invaded following electrical stimulation within the pons and medulla of rats. These neurones are dispersed throughout the PVN and are often found near neurones antidromically invaded only from the pituitary salk. In addition, a small...

journal_title：Neuroscience letters

authors： Zerihun L,Harris M

更新日期：1981-05-06 00:00:00

abstract：:N-[1-(2-Benzo(b)thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine inhibit dopamine (DA) uptake but bind to different sites on the transporter. Their dose-dependent effects (i.p. administration) on extracellular DA levels in the rat striatum were measured by in vivo microdialysis. Both drugs dose-dependently increase...

journal_title：Neuroscience letters

authors： Martin-Fardon R,Arnaud M,Rousseau E,Kamenka JM,Privat A,Vignon J

更新日期：1996-06-28 00:00:00

abstract：:Clinical practice has shown that acupuncture at facial acupoints has curative effects on some visceral diseases (especially gastrointestinal diseases). However, the physiological basis has not been clarified yet. In the present study, expression of c-fos in the nucleus of the solitary tract (NTS) of rats following gas...

journal_title：Neuroscience letters

authors： Liu JH,Li J,Yan J,Chang XR,Cui RF,He JF,Hu JM

更新日期：2004-08-12 00:00:00

abstract：:Bone-conducted ultrasound (BCU) modulated by speech sound is recognized as speech sound and activates the auditory cortex similar to audible sound. To investigate the mechanisms of perception, the effects of stimulus duration on N1m were compared among air-conducted audible speech sound (AC speech), AC speech with car...

journal_title：Neuroscience letters

authors： Okayasu T,Nishimura T,Yamashita A,Nakagawa S,Nagatani Y,Yanai S,Uratani Y,Hosoi H

更新日期：2011-05-09 00:00:00

abstract：:Painful and non-painful phantom phenomena occur frequently after amputations but are rarely investigated in the perioperative stage. The goal of the present study was the assessment of phantom phenomena, pain and changes in primary somatosensory cortex prior to and after upper limb amputation. Two patients who suffere...

journal_title：Neuroscience letters

authors： Grüsser SM,Winter C,Schaefer M,Fritzsche K,Benhidjeb T,Tunn P,Schlag PM,Flor H

更新日期：2001-04-13 00:00:00

abstract：:Carrageenan-induced inflammation of the rat hindpaw has been used as a model for persistent pain of inflammatory origin. The induction of inflammation resulting from carrageenan injection in the rat hindpaw has been shown to elicit an increase in the antinociceptive potency of morphine, an effect postulated to be rela...

journal_title：Neuroscience letters

authors： Ossipov MH,Kovelowski CJ,Porreca F

更新日期：1995-01-30 00:00:00

abstract：:We studied the number of large-sized neurons and neurofibrillary tangles (NFT) in the tuberomammillary nucleus (TM) of the hypothalamus from cases with Alzheimer's disease (AD) and age-matched controls. Numerous NFT were found in TM of AD. However, NFT was never observed in this nucleus of age-matched controls. The nu...

journal_title：Neuroscience letters

authors： Nakamura S,Takemura M,Ohnishi K,Suenaga T,Nishimura M,Akiguchi I,Kimura J,Kimura T

更新日期：1993-03-19 00:00:00

abstract：:Previous evidence has shown expression of synaptophysin by sensory cells of the auditory and vestibular systems in the human, but not in other mammalian species. Using a monoclonal antibody, SBI 20.10, we investigated the expression of synaptophysin in the sensory cells of the avian cochlea. We present immunohistochem...

journal_title：Neuroscience letters

authors： Sokolowski BH,Cunningham AM

更新日期：1996-09-27 00:00:00

abstract：:Lithium has been successfully employed therapeutically for treatment of bipolar depressive illness; however, its mechanism of action is poorly understood. Recently, it has been demonstrated by us that lithium can prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) dopaminergic neurotoxicity in mice. From analy...

journal_title：Neuroscience letters

authors： Arraf Z,Amit T,Youdim MB,Farah R

更新日期：2012-05-10 00:00:00

abstract：:Excess cholesterol is removed from the brain via hydroxylation mediated by cholesterol 24S-hydroxylase (CYP46). Although serum and cerebrospinal fluid (CSF) concentrations of 24S-hydroxycholesterol are altered during the progress of Alzheimer's disease, studies carried out to date in different populations on the assoc...

journal_title：Neuroscience letters

authors： Golanska E,Hulas-Bigoszewska K,Wojcik I,Rieske P,Styczynska M,Peplonska B,Pfeffer A,Luczywek E,Wasiak B,Gabryelewicz T,Religa D,Chodakowska-Zebrowska M,Barcikowska M,Sobow T,Liberski PP

更新日期：2005-07-22 00:00:00

abstract：:The effect of aconitine, a plant alkaloid known to bind at site 2 of the sodium channel, was investigated on neuronal excitability in hippocampal slices of adult and juvenile rats. Aconitine (0.01-1 microM) diminished the extracellularly recorded population spike in a concentration-dependent manner. At each concentrat...

journal_title：Neuroscience letters

authors： Ameri A

更新日期：1996-09-20 00:00:00

abstract：:Recent findings document numerous interactions between neuronal and glial systems that likely play a role in the pathophysiology of depression. These findings suggest that glia-derived neurotrophic protein S100B may play a significant role in developing depression. To test the relationship between S100B and depressive...

journal_title：Neuroscience letters

authors： Uher T,Bob P

更新日期：2012-11-07 00:00:00

abstract：:The effects of methysergide (1 mg, p.o.), clonidine (50 micrograms, i.m.) and methysergide plus clonidine on growth hormone (GH) and prolactin (PRL) secretion in 8 normal male volunteers have been studied. Both methysergide and clonidine were found to enhance GH and to lower PRL plasma levels. The effects of methyserg...

journal_title：Neuroscience letters

authors： Agnati LF,Benfenati F,Capelli M,Cocchi V,D'Errico A,Bernardi P

更新日期：1981-02-06 00:00:00

abstract：:The electrophysiological mechanism underlying afterhyperpolarization induced by the activation of the nicotinic acetylcholine receptor (nAChR) in male rat major pelvic ganglion neurons (MPG) was investigated using a gramicidin-perforated patch clamp and microscopic fluorescence measurement system. Acetylcholine (ACh) ...

journal_title：Neuroscience letters

authors： Park KS,Cha SK,Kim MJ,Kim NH,Lee JW,Jeong SW,Kong ID

更新日期：2010-09-27 00:00:00

abstract：:Leucine-enkephalin-like immunoreactive (ENK-LI) afferent fibers to the feline homologue of the Onuf's nucleus (pudendal motoneurons) originate mainly from lamina X of the sacral cord. They make synaptic contacts chiefly upon dendrites of pudendal motoneurons; the synaptic terminals most often contain pleomorphic synap...

journal_title：Neuroscience letters

authors： Konishi A,Itoh K,Sugimoto T,Yasui Y,Kaneko T,Takada M,Mizuno N

更新日期：1985-10-24 00:00:00

abstract：:Lesch-Nyhan syndrome (LNS), caused by the complete deficiency of hypoxanthine phosphoribosyltransferase (HPRT), is characterized by a neurological deficit, the etiology of which is still unclear. Evidence has accumulated indicating that it reflects dopamine deficiency associated with defective arborization of dopamine...

journal_title：Neuroscience letters

authors： Boer P,Brosh S,Wasserman L,Hammel I,Zoref-Shani E,Sperling O

更新日期：2001-04-27 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine involved in the development and maintenance of inflammatory and neuropathic pain conditions. The mechanisms by which TNF-alpha elicits pain behavior are still incompletely understood. Numerous studies suggest that TNF-alpha sensitizes primary affere...

journal_title：Neuroscience letters

authors： Czeschik JC,Hagenacker T,Schäfers M,Büsselberg D

更新日期：2008-04-04 00:00:00

abstract：:Insulin-like growth factor binding protein (IGFBP) 7 may be a critical regulator of memory consolidation. This study was performed to assess the relationship between circulating IGFBP7 levels and postoperative cognition dysfunction (POCD) in patients scheduled for elective head and neck carcinoma surgery under general...

journal_title：Neuroscience letters

authors： Jiang J,Chen Z,Liang B,Yan J,Zhang Y,Xu H,Huang Y,Jiang H

更新日期：2015-02-19 00:00:00

abstract：:While past research suggests that ghrelin stimulates appetite through an action on hypothalamic signaling, recent evidence indicates that the peptide acts via mesotelencephalic dopamine neurons to alter appetitive motivation. In the present study, rats were trained to operantly respond for food on a progressive ratio ...

journal_title：Neuroscience letters

authors： Weinberg ZY,Nicholson ML,Currie PJ

更新日期：2011-07-20 00:00:00

abstract：:The extracellular concentrations of the lipid peroxidation product malonaldehyde (MDA) and the antioxidants ascorbic and uric acid were measured in rat brain in vivo using microdialysis coupled to HPLC with ultra violet spectrophotometry. Treatment with kainic acid at pH 4.1 (50 nmol) caused a significant increase in ...

journal_title：Neuroscience letters

authors： Waterfall AH,Singh G,Fry JR,Marsden CA

更新日期：1995-11-10 00:00:00

abstract：:Effects of conceptual fusion on episodic associative retrieval were examined. Subjects attempted to fuse sequentially displayed (800 ms offset) word pairs; pairs subjects were unable to fuse were instead considered associated by juxtaposition. Next, dense-array event-related potentials (ERPs) were recorded while the p...

journal_title：Neuroscience letters

authors： Kounios J,Bachman P,Casasanto D,Grossman M,Smith RW,Yang W

更新日期：2003-07-24 00:00:00