Abstract:
:Infarct volume and immunoreactivities for trkB and trkC in rat brain were compared at 24 h after 90 min of transient middle cerebral artery occlusion (MCAO) between animal groups with or without neurotrophin-3 (NT-3, 10 microg/250 g animal). Treatment of rat brain with topical application of NT-3 significantly reduced infarct volume (P = 0.02) and trkB and trkC inductions. These data suggest that NT-3 reduced the ischemic injury along with the reduction of trkB and trkC inductions.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Zhang WR,Hayashi T,Wang JM,Sasaki C,Sakai K,Warita H,Shiro Y,Suenaga H,Ohmae H,Tsuji S,Itoh T,Nishimura O,Nagasaki H,Abe Kdoi
10.1016/s0304-3940(99)00848-4keywords:
subject
Has Abstractpub_date
1999-12-10 00:00:00pages
161-4issue
3eissn
0304-3940issn
1872-7972pii
S0304394099008484journal_volume
276pub_type
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