Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat.

Abstract:

:Infarct volume and immunoreactivities for trkB and trkC in rat brain were compared at 24 h after 90 min of transient middle cerebral artery occlusion (MCAO) between animal groups with or without neurotrophin-3 (NT-3, 10 microg/250 g animal). Treatment of rat brain with topical application of NT-3 significantly reduced infarct volume (P = 0.02) and trkB and trkC inductions. These data suggest that NT-3 reduced the ischemic injury along with the reduction of trkB and trkC inductions.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Zhang WR,Hayashi T,Wang JM,Sasaki C,Sakai K,Warita H,Shiro Y,Suenaga H,Ohmae H,Tsuji S,Itoh T,Nishimura O,Nagasaki H,Abe K

doi

10.1016/s0304-3940(99)00848-4

keywords:

subject

Has Abstract

pub_date

1999-12-10 00:00:00

pages

161-4

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394099008484

journal_volume

276

pub_type

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