Abstract:
:N-Methyl-D-aspartate (NMDA, 500 ng/0.5 microliters), alpha-amino-3-hydroxy-5-methyl-4-isoxasole-propionic acid (AMPA, 1000 ng/0.5 microliters), or kainic acid (50 ng/0.5 microliters) injected into intermediate and caudal parts of the caudate-putamen induced contralateral head turns and rotations. Picrotoxin (250 ng/0.5 microliters) injected into the same striatal region 30 min before NMDA, AMPA, or kainic acid strongly increased the contralateral turning induced by each of those compounds. The present results suggest that blockade of gamma-aminobutyric acid (GABA)A receptor complex by picrotoxin rendered striatal neurons more sensitive to the action of glutamate on NMDA and non-NMDA receptors.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ossowska Kdoi
10.1016/0304-3940(95)12198-6subject
Has Abstractpub_date
1995-12-29 00:00:00pages
57-60issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(95)12198-6journal_volume
202pub_type
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