Interaction between striatal excitatory amino acid and gamma-aminobutyric acid (GABA) receptors in the turning behaviour of rats.

Abstract:

:N-Methyl-D-aspartate (NMDA, 500 ng/0.5 microliters), alpha-amino-3-hydroxy-5-methyl-4-isoxasole-propionic acid (AMPA, 1000 ng/0.5 microliters), or kainic acid (50 ng/0.5 microliters) injected into intermediate and caudal parts of the caudate-putamen induced contralateral head turns and rotations. Picrotoxin (250 ng/0.5 microliters) injected into the same striatal region 30 min before NMDA, AMPA, or kainic acid strongly increased the contralateral turning induced by each of those compounds. The present results suggest that blockade of gamma-aminobutyric acid (GABA)A receptor complex by picrotoxin rendered striatal neurons more sensitive to the action of glutamate on NMDA and non-NMDA receptors.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Ossowska K

doi

10.1016/0304-3940(95)12198-6

subject

Has Abstract

pub_date

1995-12-29 00:00:00

pages

57-60

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(95)12198-6

journal_volume

202

pub_type

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