Abstract:
:Methamphetamine (METH) is one of the most commonly abused substances in today's society. Many studies have shown that the process of cell death induced by METH involves with the reception of death signals, an increase in pro-apoptotic proteins (Bax) and an activation of cysteine protease death pathway. The objective of this study was to investigate the neuroprotective effects of calpastatin against METH-induced toxicity in SH-SY5Y neuroblastoma cells by observing cell viability, phosphorylation of transcription factor, c-Jun (phospho-c-Jun) and levels of Bax and Bcl-2. The results showed that METH significantly decreased cell viability in SH-SY5Y cultured cells. Conversely, increase in phospho-c-Jun and Bax/Bcl-2 ratio was observed in METH-treated cells. Calpastatin reversed the toxic effect of METH by increasing cell viability, reducing phospho-c-Jun and Bax/Bcl-2 ratio in METH-treated cells. These results indicated that calpastatin has the capacity to reverse an activation of the death process in METH-treated dopaminergic cell lines.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Chetsawang J,Suwanjang W,Pirompul N,Govitrapong P,Chetsawang Bdoi
10.1016/j.neulet.2011.10.021subject
Has Abstractpub_date
2012-01-06 00:00:00pages
7-11issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(11)01407-8journal_volume
506pub_type
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