Abstract:
:Neurotrophic factors maintain and modulate neuron function in adults. We tested the hypothesis that neurotrophic factors rapidly alter intracellular calcium concentrations, thereby affecting neuron excitability. The majority of rat nodose neurons express TrkA, TrkB and TrkC receptor after 1 day in culture. Addition of nerve growth factor, brain derived neurotrophic factor or glial derived neurotrophic factor increased cytosolic calcium in about one third of the neurons within less than 10 min. This increase was due to calcium release from intracellular stores and could be blocked by the tyrosine kinase inhibitor K252a. The rapid effect of neurotrophic factors suggests a role of these molecules in the early response after inflammation as potential mediators for sensitization of afferent neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lamb K,Bielefeldt Kdoi
10.1016/s0304-3940(02)01223-5keywords:
subject
Has Abstractpub_date
2003-01-09 00:00:00pages
9-12issue
1eissn
0304-3940issn
1872-7972pii
S0304394002012235journal_volume
336pub_type
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