Abstract:
:Jet propulsion fuel-8 (JP-8) is the predominant fuel for military land vehicles and aircraft used in the US and NATO. Occupational exposure to jet fuel in military personnel has raised concern for the health risk associated with such exposure in the Department of Defense. Clinical studies of humans chronically exposed to jet fuel have suggested both neurotoxicity and neurobehavioral deficits. We utilized rat neurobiology U34 array to measure gene expression changes in whole brain tissue of rats exposed repeatedly to JP-8, under conditions that simulated possible occupational exposure (6 h/day for 91 days) to JP-8 vapor at 250, 500, and 1000 mg/m(3), respectively. Our studies revealed that the gene expression changes of exposure groups can be divided into two main categories according to their functions: (1). neurotransmitter signaling pathways; and (2). stress response. The implications of these gene expression changes are discussed.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lin B,Ritchie GD,Rossi J 3rd,Pancrazio JJdoi
10.1016/j.neulet.2004.03.056keywords:
subject
Has Abstractpub_date
2004-06-17 00:00:00pages
233-8issue
3eissn
0304-3940issn
1872-7972pii
S0304394004003799journal_volume
363pub_type
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