Abstract:
:Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) are neurodegenerative diseases that may share genetic risk factors. The exon variant Aal58Val (rs17571) in CTSD was recently associated with AD, leading us to examine whether it also affects risk of ALS and PD. The rs17571 variant was genotyped using the ligase detection reaction in 569 Han Chinese patients with PD, 301 patients with ALS, and healthy controls age- and gender-matched to each patient group. The frequencies of genotypes and alleles were similar between each disease group and its respective control group. Similar results were obtained when patients were stratified by gender, age at disease onset or type of symptoms at disease onset. These results suggest that the CTSD rs17571 variant may not be associated with risk of ALS or PD in Han Chinese.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Xi J,Yang X,Zhao Q,Zheng J,An R,Tian S,Huang H,Hu F,Ning P,Xu Ydoi
10.1016/j.neulet.2017.09.029subject
Has Abstractpub_date
2018-01-01 00:00:00pages
181-184eissn
0304-3940issn
1872-7972pii
S0304-3940(17)30771-1journal_volume
662pub_type
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