Expression of functional metabotropic and ionotropic glutamate receptors in baculovirus-infected insect cells.

abstract：:In precontracted, endothelium-free guinea pig mesenteric artery rings, in which adrenergic vasoconstrictor responses had been eliminated, guanethidine (1-30 microM) produced a vasodilatation of 69.3+/-4.4%. The vasodilatation was reduced 89% by capsaicin (10 microM) or 55% by tetrodotoxin (10 microM), indicating media...

journal_title：Neuroscience letters

authors： Zheng ZL,Shimamura K,Anthony TL,Kreulen DL

更新日期：2000-07-21 00:00:00

abstract：:Retinal action potential (RAP) was recorded at different depths in the median eye of scorpion, using a glass micropipette electrode (tip diameter 2-3 mum). The amplitude of RAP was largest when the tip of the electrode touched the distal process of the receptor cell (RC). The polarity of RAP became reversed when the t...

journal_title：Neuroscience letters

authors： Ramakrishna T

更新日期：1977-06-01 00:00:00

abstract：:The effect of 4-aminopyridine (4-AP) on long-term potentiation (LTP) was studied in the hippocampal slice preparation of the rat. Field excitatory postsynaptic potentials (EPSPs) were recorded and evoked in the stratum radiatum of the CA1. Both the low frequency EPSP and LTP of the EPSP were significantly increased by...

journal_title：Neuroscience letters

authors： Lee WL,Anwyl R,Rowan M

更新日期：1986-09-25 00:00:00

abstract：:Tryptophan hydroxylase 2 (TPH2) is a rate-limiting enzyme of neuronal serotonin biosynthesis. Recently, two single nucleotide polymorphisms (SNPs) at the exon 11 coding region that resulted in amino acid substitutions in the C-terminal domain have been reported to affect enzyme activity in humans and mice. We determin...

journal_title：Neuroscience letters

authors： Hong KW,Sugawara Y,Hasegawa H,Hayasaka I,Hashimoto R,Ito S,Inoue-Murayama M

更新日期：2007-02-02 00:00:00

abstract：:Diabetic retinopathy is a leading cause of vision loss and blindness. Increasing evidence has shown that the neuronal components of the retina are affected even before the detection of vascular lesions. Hyperglycemia is considered the main pathogenic factor for the development of diabetic complications. Nevertheless, ...

journal_title：Neuroscience letters

authors： Baptista FI,Castilho ÁF,Gaspar JM,Liberal JT,Aveleira CA,Ambrósio AF

更新日期：2015-08-18 00:00:00

abstract：:We examined the distribution of ferric ion-ferrocyanide stain (a marker for excitable regions of myelinated fibers) in the lead-induced demyelinating neuropathy of the rat. By electron microscopy, we found that paranodal degeneration resulted in spreading of the reaction product from nodal to internodal axolemma. Duri...

journal_title：Neuroscience letters

authors： Coria F,Silos I,Fernandez R,Monton F,Lafarga M

更新日期：1985-08-05 00:00:00

abstract：:Recently, we demonstrated that dimeric apocynin prevented loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic (tg) mouse (treated with 200mg/kg, three times per week) [B.P. Dranka et al., Neurosci. Lett. 549 (2013) 57-62]. Here we extend those studies by treating LRRK2(R1441G) mice wi...

journal_title：Neuroscience letters

authors： Dranka BP,Gifford A,McAllister D,Zielonka J,Joseph J,O'Hara CL,Stucky CL,Kanthasamy AG,Kalyanaraman B

更新日期：2014-11-07 00:00:00

abstract：:In urethane-anesthetized rats, injections of 50 pmol of arginine-vasopressin (AVP) or thyrotropin-releasing hormone (TRH) into a lateral cerebral ventricle (i.c.v.) elicit short-latency increases in blood pressure. i.c.v. injection of 50 pmol of the AVP antagonist, d(CH2)5Tyr(Me)AVP, but not of the vehicle (artificial...

journal_title：Neuroscience letters

authors： Pittman QJ,Franklin LG

更新日期：1985-05-14 00:00:00

abstract：:Approximately 8.5% of the unmyelinated and 2.5% of the myelinated primary afferent axons in lumbar dorsal roots of normal rats are immunostained for glutamate. Thus unmyelinated fibers are the predominantly immunostained population under the conditions of our experiments. The mean size of the unmyelinated fibers is gr...

journal_title：Neuroscience letters

authors： Westlund KN,McNeill DL,Coggeshall RE

更新日期：1989-01-02 00:00:00

abstract：:Incorporation of the N-methyl-d-aspartate receptor (NMDAR) subunit NR3A into functional NMDARs results in reduced channel conductance and Ca(2+) permeability. To further investigate the function of NR3A, we have set out to characterize its intracellular binding partners. Here, we report a novel protein interaction bet...

journal_title：Neuroscience letters

authors： Eriksson M,Samuelsson H,Björklund S,Tortosa E,Avila J,Samuelsson EB,Benedikz E,Sundström E

更新日期：2010-05-07 00:00:00

abstract：:A paired-pulse stimulus protocol was used to measure angular bundle to dentate gyrus paired-pulse inhibition in rats before and after the occurrence of 36 or 72 seizures elicited from the contralateral CA3 region. The seizures showed progressive lengthening. There was a moderate increase in paired-pulse depression 1 h...

journal_title：Neuroscience letters

authors： Stringer JL,Lothman EW

更新日期：1989-10-23 00:00:00

abstract：:The perception of visual motion is dependent on a set of occipitotemporal regions that are readily accessible to neuromodulation. The current study tested if paired-pulse Transcranial Magnetic Stimulation (ppTMS) could modulate motion perception by stimulating the occipital cortex as participants viewed near-threshold...

journal_title：Neuroscience letters

authors： Gamboa OL,Brito A,Abzug Z,D'Arbeloff T,Beynel L,Wing EA,Dannhauer M,Palmer H,Hilbig SA,Crowell CA,Liu S,Donaldson R,Cabeza R,Davis SW,Peterchev AV,Sommer MA,Appelbaum LG

更新日期：2020-06-21 00:00:00

abstract：:Heat shock protein 70 family was demonstrated to play a critical role in protein homeostasis, a process profoundly impaired in neurodegenerative disorders. Neurodegenerative diseases are characterized by the accumulation of different kind of proteins and the formation of insoluble aggregates which are toxic for neuron...

journal_title：Neuroscience letters

authors： Sirtori R,Riva C,Ferrarese C,Sala G

更新日期：2020-09-25 00:00:00

abstract：:The expression of neuronal nicotinic acetylcholine receptors (nAChRs) influenced by lipid peroxidation has been investigated. The results showed that exposure of PC12 cells to a free radical insult (FeSO(4)) induced concentration-dependent increase in level of MDA (malondialdehyde), and a significant decline in MTT [3...

journal_title：Neuroscience letters

authors： Guan Z,Zhang X,Nordberg A

更新日期：2000-06-09 00:00:00

abstract：:The epithelial membrane protein 1 (EMP1) plays a role in neuronal differentiation and neurite outgrowth, which are involved in the pathogenesis of major depressive disorder (MDD). We sought to determine whether the EMP1 gene is implicated in MDD. We determined the mRNA expression levels of the EMP1 gene in peripheral-...

journal_title：Neuroscience letters

authors： Nakataki M,Iga J,Numata S,Yoshimoto E,Kodera K,Watanabe SY,Song H,Ueno S,Ohmori T

更新日期：2011-02-04 00:00:00

abstract：:While alpha- and beta-synuclein largely overlap in their expression in the vertebrate brain, only alpha-synuclein accumulates in the fibrillar aggregates typical of Parkinson's disease. It is thus critical to have immunological reagents that distinguish between these two protein isoforms. The monoclonal antibody Syn-1...

journal_title：Neuroscience letters

authors： Perrin RJ,Payton JE,Barnett DH,Wraight CL,Woods WS,Ye L,George JM

更新日期：2003-10-02 00:00:00

abstract：:We previously identified a novel molecule "Shati/Nat8l" from the nucleus accumbens of mice. However, the physiological roles of the SHATI protein are not clear. To investigate the effect of SHATI on the central nervous system and behavior, we studied knockout mice of this protein. We carried out various behavior tests...

journal_title：Neuroscience letters

authors： Furukawa-Hibi Y,Nitta A,Fukumitsu H,Somiya H,Toriumi K,Furukawa S,Nabeshima T,Yamada K

更新日期：2012-09-27 00:00:00

abstract：:Cyclosporine A (CsA) is the major immunosuppressive drug used for organ and neural transplantation and the therapy of selected autoimmune diseases. We investigated the effect of CsA on the activity of acetylcholinesterase (AChE) in the frontal cortex, hippocampus, septum, and basal ganglia. AChE was determined spectro...

journal_title：Neuroscience letters

authors： Herink J,Krejcová G,Bajgar J,Svoboda Z,Kvĕtina J,Zivnú P,Palicka V

更新日期：2003-03-27 00:00:00

abstract：:Prevention of beta-amyloid (Abeta) production, aggregation and formation of Abeta deposits is a key pharmacological target in Alzheimer's disease. The passage of Abeta-binding compounds through the blood-brain barrier is often hampered for free ligands, whereas it is enhanced by drug encapsulation in nanoparticles. He...

journal_title：Neuroscience letters

authors： Härtig W,Paulke BR,Varga C,Seeger J,Harkany T,Kacza J

更新日期：2003-02-27 00:00:00

abstract：:Acetylcholine (Ach) has been considered a major neurotransmitter in the inner ear efferent nerve endings. A bioassay analysis has shown that the electrical stimulation of the crossed olivocochlear bundle increased the Ach-like activity in the perilymph. Applying in vivo microdialysis techniques and high-performance li...

journal_title：Neuroscience letters

authors： Hoya N,Ogawa K,Inoue Y,Takiguchi Y,Kanzaki J

更新日期：2001-10-05 00:00:00

abstract：:Accumulating evidence suggests that abnormal fatty acid composition is related to the development of Alzheimer's disease (AD). However, there is no consistency in the fatty acid profile and metabolism associated with AD pathogenesis. This study aims to define the characteristics of fatty acid composition and metabolis...

journal_title：Neuroscience letters

authors： Bai YR,Wang YY,Meng DL,Shi ZL,Song XF,Yang ZZ,Zhang W,Yang L,Shi RL

更新日期：2020-11-01 00:00:00

abstract：:Insulin secretion and glucose homeostasis is implicated through serotonergic function. Pyridoxine is involved in decarboxylation step in synthesis of serotonin. The present study was carried out to find the role of insulin in combination with pyridoxine on the concentrations of 5-HT and 5-HIAA, 5-HT receptor binding, ...

journal_title：Neuroscience letters

authors： Abraham PM,Anju TR,Jayanarayanan S,Paulose CS

更新日期：2010-10-08 00:00:00

abstract：:The effects of bilateral cut of the stria terminalis (ST) on the dosage of estradiol benzoate (EB) needed to induce the lordosis reflex in the ovariectomized female rat were examined. Seven different doses ranging 0.5-20 micrograms were given s.c. in oil, daily for 2 days in a counterbalanced order, at 3-week interval...

journal_title：Neuroscience letters

authors： Takeo T,Kudo M,Sakuma Y

更新日期：1995-01-23 00:00:00

abstract：:Bone-conducted ultrasound (BCU) modulated by speech sound is recognized as speech sound and activates the auditory cortex similar to audible sound. To investigate the mechanisms of perception, the effects of stimulus duration on N1m were compared among air-conducted audible speech sound (AC speech), AC speech with car...

journal_title：Neuroscience letters

authors： Okayasu T,Nishimura T,Yamashita A,Nakagawa S,Nagatani Y,Yanai S,Uratani Y,Hosoi H

更新日期：2011-05-09 00:00:00

abstract：:We established the procedures for cryopreservation and primary culture of fetal cerebral neurons of cynomolgus monkeys (Macaca fascicularis). Three developmental stages of fetuses (80, 93, and 102 days of gestation) were compared to determine the optimal stage of cerebrum development for primary culture. Among the thr...

journal_title：Neuroscience letters

authors： Negishi T,Ishii Y,Kawamura S,Kuroda Y,Yoshikawa Y

更新日期：2002-08-02 00:00:00

abstract：:Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are characterized by T cell-mediated autoimmune inflammation of the central nervous system (CNS) leading to oligodendrocyte loss and demyelination accompanied by neuronal cell death. Neuronal TWIK-related acid-sensitive potass...

journal_title：Neuroscience letters

authors： Meuth SG,Kanyshkov T,Melzer N,Bittner S,Kieseier BC,Budde T,Wiendl H

更新日期：2008-12-03 00:00:00

abstract：:Constant bright light (LL) suppresses 24-h melatonin and many other behavioral and physiological rhythms in pigeons. LL also strongly suppresses sleep. Daily melatonin infusions in LL restore sleep to normal nocturnal levels of a light-dark cycle and continuous infusions sustain it for at least 10 days. Restoration of...

journal_title：Neuroscience letters

authors： Phillips NH,Berger RJ

更新日期：1992-10-12 00:00:00

abstract：:This study investigates whether potassium ion (K+) channels are involved in the nitric oxide (NO)-induced relaxation in segments of the isolated rat basilar artery, mounted onto a wire myograph. A high extracellular K+ concentration partly inhibited the relaxant effects of the NO donors DEA/NO and SIN-1 (3-morpholino-...

journal_title：Neuroscience letters

authors： Hempelmann RG,Seebeck J,Kruse ML,Ziegler A,Mehdorn HM

更新日期：2001-11-02 00:00:00

abstract：:In newborns, hypoxia elicits defensive behaviors including awakening from sleep, body movements and crying. An inability to produce this defense response is a risk factor for sudden infant death syndrome and other respiratory control disorders. In this study, we examined the possibility that the defense response to hy...

journal_title：Neuroscience letters

authors： Bollen B,Bouslama M,Matrot B,D'Hooge R,Van den Bergh O,Gallego J

更新日期：2007-06-15 00:00:00

abstract：:The cells of the entorhinal cortex receive a dense innervation of serotonergic fibres from the Raphe nuclei and express a high density of 5-hydroxytryptamine 1A (5-HT1A) receptors. We investigated the effects of serotonin on excitatory synaptic transmission in principal cells from entorhinal cortex layers II and III w...

journal_title：Neuroscience letters

authors： Schmitz D,Empson RM,Gloveli T,Heinemann U

更新日期：1995-04-28 00:00:00