Abstract:
:Prevention of beta-amyloid (Abeta) production, aggregation and formation of Abeta deposits is a key pharmacological target in Alzheimer's disease. The passage of Abeta-binding compounds through the blood-brain barrier is often hampered for free ligands, whereas it is enhanced by drug encapsulation in nanoparticles. Here, we describe the preparation and characterization of polymeric carriers containing thioflavin-T as a marker for fibrillar Abeta. This study is then focused on electron microscopic analyses of thioflavin-T after injection of thioflavin-T-containing nanoparticles into the mouse hippocampus. Therefore, the photoconversion of fluorescent thioflavin-T as model drug was performed in tissues fixed 3 days post-injection. Thioflavin-T delivered from nanospheres was predominantly found in neurons and microglia. Our data suggest that drugs delivered by nanoparticles might target Abeta in the brain.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Härtig W,Paulke BR,Varga C,Seeger J,Harkany T,Kacza Jdoi
10.1016/s0304-3940(02)01399-xkeywords:
subject
Has Abstractpub_date
2003-02-27 00:00:00pages
174-6issue
2eissn
0304-3940issn
1872-7972pii
S030439400201399Xjournal_volume
338pub_type
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