Abstract：
:Mice exposed to intermittent cold stress (ICS), but not constant cold stress (CCS) showed sustained thermal hyperalgesia for up to 12 days. Systemic or intracerebroventricular (i.c.v.) injection of morphine caused no significant analgesia in ICS mice, but induced dose-dependent analgesia in control mice. However, significant analgesic effects were achieved by intrathecal or intraplantar injection of morphine. The i.c.v. injection of morphine significantly increased the turnover ratio (5-HIAA/5-HT) in the dorsal half of the spinal cord of control mice, but not in ICS mice. Collectively, these results indicate that the loss of descending serotonergic activation seems to be a key mechanism underlying the absence of morphine-induced analgesia.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Nishiyori M,Nagai J,Nakazawa T,Ueda Hdoi
10.1016/j.neulet.2010.01.080subject
Has Abstractpub_date
2010-03-26 00:00:00pages
184-7issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(10)00147-3journal_volume
472pub_type
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