Abstract:
:We examined the effect of intraventricular injection of nerve growth factor (NGF) on the choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) mRNA expression in the septa of neonatal rats. Rat pups were injected with 2.5 S NGF or cytochrome-c (control) on postnatal days (PN) 4 and 18, and sacrificed 3 days after injections for analysis of ChAT and VAChT mRNA levels by dot-blot hybridization of total septal RNA. In the NGF-treated pups, the ChAT and VAChT mRNA levels were elevated 3- and 2-fold, respectively, at PN7, and 1.8- and 1.3-fold at PN21. These results indicate that (1) NGF upregulates the expression of both ChAT and VAChT genes, (2) NGF has a greater effect on the expression of ChAT mRNA than VAChT mRNA, and (3) the effect of exogenous NGF on the expression of both genes diminishes with developmental age.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tian X,Sun X,Suszkiw JBdoi
10.1016/0304-3940(96)12629-xsubject
Has Abstractpub_date
1996-05-10 00:00:00pages
134-6issue
2eissn
0304-3940issn
1872-7972pii
030439409612629Xjournal_volume
209pub_type
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