Abstract:
:The possibility for the induction of long-lasting synaptic plasticity by the potassium channel blocker tetraethylammonium (TEA) was investigated in adult rat motor cortex in vitro. Brief application of TEA (25 mM) resulted in a long-term potentiation (LTP(K)) of field potentials evoked in layer V intralaminar connections by 59+/-17%. This effect could be prevented by preincubation with nifedipine, a voltage-dependent calcium channel blocker (20 microM), but not by N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovalerate (APV, 100 microM). LTP(K) induction resulted in a smaller relative potentiation of a response to the second pulse of a pair (60 ms interpulse interval). These results indicate a potential of layer V horizontal connections for a NMDA receptor-independent form of persistent synaptic enhancement.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Jagodzinski P,Hess Gdoi
10.1016/s0304-3940(00)01715-8keywords:
subject
Has Abstractpub_date
2001-01-26 00:00:00pages
37-40issue
1eissn
0304-3940issn
1872-7972pii
S0304394000017158journal_volume
298pub_type
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