Neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on striatal biopterin in BALB/c mice.

abstract：:Expression levels of amyloid beta (Abeta)-degrading enzymes, insulin degrading enzyme (IDE) and neprilysin (NEP), were examined in transgenic mice with Alzheimer's disease-like neuropathology. After the development of first Abeta plaques in transgenic mice brain, cortical mRNA and protein levels of IDE were significan...

journal_title：Neuroscience letters

authors： Vepsäläinen S,Hiltunen M,Helisalmi S,Wang J,van Groen T,Tanila H,Soininen H

更新日期：2008-06-20 00:00:00

abstract：:The current study investigated the time course of the affective processing bias in major depressive disorder (MDD) in a visual three-stimulus semantic oddball task using event-related potentials (ERPs). MDD patients showed decreased P1 latency over right posterior regions to negative relative to positive target stimul...

journal_title：Neuroscience letters

authors： Yang W,Zhu X,Wang X,Wu D,Yao S

更新日期：2011-01-10 00:00:00

abstract：:Morphine analgesia measured by the tail withdrawal test was examined in rats that were either restrained or left free during testing. It was found that restraint potentiated morphine analgesia and decreased the latency of the peak analgesic effect. Methysergide, a serotonin antagonist, and valine, which prevents the i...

journal_title：Neuroscience letters

authors： Kelly SJ,Franklin KB

更新日期：1984-02-24 00:00:00

abstract：:It is generally assumed that the majority of substance P (SP)-containing afferents are also immunoreactive for calcitonin gene-related peptide (CGRP). In order to determine whether this is also the case in articular afferents where the contents of these peptides are low, we carried out a double labeling study using Fa...

journal_title：Neuroscience letters

authors： Tamura R,Hanesch U,Schmidt RF,Kumazawa T,Mizumura K

更新日期：1998-09-18 00:00:00

abstract：:Utilizing the push-pull perfusion technique, we examined the secretory profiles of neuropeptide Y (NPY) and luteinizing hormone (LH)-releasing hormone (LHRH) in the median eminence (ME) of ovariectomized adult rats which were primed with estrogen and progesterone to provoke LH and prolactin (PRL) surges. The ME was pe...

journal_title：Neuroscience letters

authors： Watanobe H,Takebe K

更新日期：1992-10-26 00:00:00

abstract：:We reported here the functional characteristics of Na+ -dependent neutral amino acid transport system A in normal human astrocytes and its adaptive regulation, a process in which amino acid starvation induces the transport activity. Reverse transcription-PCR revealed that the system A transporter subtype, SNAT2/ATA2, ...

journal_title：Neuroscience letters

authors： Tanaka K,Yamamoto A,Fujita T

更新日期：2005-04-18 00:00:00

abstract：:In order to clarify the mechanism of action of cerulenin analog, C75, known to suppress feeding behavior, food intake was measured in adult CD-1 male mice n=5 per group, treated i.p. with 10 and 20mg/kg of C75. Animals in both treatment groups had significantly lower 24h food consumption rate relative to the control g...

journal_title：Neuroscience letters

authors： Binienda ZK,Ross IA,Gough B,Riccio T,Kim CS,Ali SF

更新日期：2010-01-29 00:00:00

abstract：:Peripheral nerve damage causes a dramatic alteration to the gene expression in primary sensory neurons, changes within the neuronal cell body giving rise to an altered phenotype, adapted for axonal regeneration. Such changes suggest an alteration in activity, or levels, of cellular transcription factors. The POU famil...

journal_title：Neuroscience letters

authors： Begbie JL,Wood JN,Anderson PN,Latchman DS

更新日期：1996-04-05 00:00:00

abstract：:Current theories of orbitofrontal cortex (OFC) function suggest that this region should participate in the generation of error-related signals associated with the outcomes of actions. We investigated the impact of lesions to OFC on the error-related negativity (ERN), an electrophysiological marker of performance monit...

journal_title：Neuroscience letters

authors： Turken AU,Swick D

更新日期：2008-08-15 00:00:00

abstract：:Application of strychnine sulfate (10-50 mu M) to the anterior hindlimb enlargement of the turtle spinal cord increased the amplitude of the ipsilateral fictive flexion reflex and revealed a contralateral (crossed) fictive flexion reflex response to cutaneous stimulation of the foot. Strychnine abolished the crossed i...

journal_title：Neuroscience letters

authors： Currie SN,Lee S

更新日期：1996-02-23 00:00:00

abstract：:Chronic morphine administration induces neural plasticity followed by withdraw. And clinic observation indicates that obvious cognitive deficits are found during withdrawal. However, current neural substrates that regulate dysfunction in withdrawal are unknown. In our studies, chronic morphine administration was used ...

journal_title：Neuroscience letters

authors： Niu H,Zhang G,Li H,Zhang Q,Li T,Ding S,Wang L,Zhang Z,Qiao Y,Hu M

更新日期：2017-02-15 00:00:00

abstract：:Nitric oxide, an endogenous gas produced by nitric oxide synthase (NOS), has been described as a neuromodulator of hormone secretion, including the neurohypophysial peptides oxytocin (OT) and vasopressin (AVP), hormones involved in the sodium and water homeostasis. The presence of NOS in the hypothalamic nuclei as wel...

journal_title：Neuroscience letters

authors： Ventura RR,Giusti-Paiva A,Gomes DA,Elias LL,Antunes-Rodrigues J

更新日期：2005-05-06 00:00:00

abstract：BACKGROUND:Chronic postoperative pain (CPOP) is a common clinical problem which might be related to central sensitization. It has been widely accepted that NMDA (N-methyl-D-aspartate) receptors are among the triggers of central sensitization. Ketamine is a non-competitive NMDA receptor antagonist that is widely used in...

journal_title：Neuroscience letters

authors： Shen Y,Xu L,Liu M,Lei Y,Gu X,Ma Z

更新日期：2016-03-11 00:00:00

abstract：:Loss of ganglion cells is a common and irreversible complication of hair cell loss in the cochlea. Gene transfer could potentially be used to prevent this neuronal degeneration and other pathologies in the cochlea. Human adenoviruses should provide a feasible gene transfer vehicle for transducing the quiescent cochlea...

journal_title：Neuroscience letters

authors： Raphael Y,Frisancho JC,Roessler BJ

更新日期：1996-03-29 00:00:00

abstract：:In guinea pig hippocampal slices, 4-aminopyridine (4-AP) in concentrations of 100-500 microM reduced the adaptation of CA3 pyramidal neurons to depolarizing stimuli, resulting in a prolongation of repetitive firing during injection of long-lasting depolarizing currents. Concurrently, there was a decrease in the 'sag' ...

journal_title：Neuroscience letters

authors： Matsuda Y,Yoshida S,Fujimura K,Nakamura M

更新日期：1986-04-24 00:00:00

abstract：:The present study evaluated the relationship between asymmetry of the prefrontal cortex activity and the automatic nervous system (ANS) response during a mental arithmetic (MA) task. Employing near infrared spectroscopy, we compared cerebral blood oxygenation changes in the right and left prefrontal cortices during a ...

journal_title：Neuroscience letters

authors： Tanida M,Sakatani K,Takano R,Tagai K

更新日期：2004-10-07 00:00:00

abstract：:The kynurenine pathway converts tryptophan into various compounds, including L-kynurenine, which in turn can be converted to the excitatory amino acid receptor antagonist kynurenic acid. The hypothesis that endogenously-produced kynurenic acid could have physiological effects was tested in combined entorhinal/hippocam...

journal_title：Neuroscience letters

authors： Scharfman HE,Ofer A

更新日期：1997-03-14 00:00:00

abstract：:The pharmacological properties of presynaptic calcium (Ca) channels on rat hippocampal mossy fiber synaptosomes were characterized by determining the inhibitory potencies for various classes of Ca antagonists on depolarization-induced Ca mobilization and the release of dynorphin A(1-8)-like immunoreactivity (Dyn-LI). ...

journal_title：Neuroscience letters

authors： Terrian DM,Damron DS,Dorman RV,Gannon RL

更新日期：1989-12-04 00:00:00

abstract：:In freshly dissociated viable cells of early postnatal mouse cerebellum, O1 antigen-positive oligodendrocytes have been eliminated by complement dependent immunocytolysis. Before seeding residual cells in culture, O4 antigen-positive cells were immunolabeled by O4 antibody which had been directly conjugated with rhoda...

journal_title：Neuroscience letters

authors： Sommer I,Schachner M

更新日期：1982-04-16 00:00:00

abstract：:This study was designed toinvestigate the efficacy of adenovirus vector-mediated brain-derived neurotrophic factor (BDNF) ex vivo gene transfer to human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) in a rat sciatic nerve crush injury model. BDNF protein and mRNA expression after infection was checked...

journal_title：Neuroscience letters

authors： Hei WH,Almansoori AA,Sung MA,Ju KW,Seo N,Lee SH,Kim BJ,Kim SM,Jahng JW,He H,Lee JH

更新日期：2017-03-16 00:00:00

abstract：:Pyramidal neurons in the mammalian cerebral cortex can be described by a fractal dimension (Mandelbrot, 1982), which is an objective, quantitative measure of the complexity of their soma/dendritic borders. In the cat, the fractal dimensions of lamina V cells, which include pyramidal tract neurons (PTN), indicate that ...

journal_title：Neuroscience letters

authors： Porter R,Ghosh S,Lange GD,Smith TG Jr

更新日期：1991-09-02 00:00:00

abstract：:The aim of this study was to investigate trigeminal nerve involvement in patients with peripheral facial palsy. In total, 25 patients with facial nerve palsy and 19 controls were tested by electrophysiological methods regarding their facial and trigeminal nerve functions within 1 month after disease onset. The presenc...

journal_title：Neuroscience letters

authors： Uluduz D,Kiziltan ME,Akalin MA

更新日期：2010-07-26 00:00:00

abstract：:We have previously shown that mu-selective opioid agonists activate both an inward rectifying and a voltage-gated potassium conductance in acutely dissociated non-pyramidal neurons from rat hippocampus. We now report that the opioid-activated voltage-gated potassium conductance was blocked by the membrane permeable cA...

journal_title：Neuroscience letters

authors： Wimpey TL,Chavkin C

更新日期：1992-03-16 00:00:00

abstract：:Neovascularization of the dissociated central nervous tissue transplanted into the lateral ventricle of the rat was studied using laminin immunohistochemistry. A very high immunoreactive response to laminin was demonstrated in the presumably newly formed vessels within the transplants and the graft-host borders. The g...

journal_title：Neuroscience letters

authors： Shigematsu K,Kamo H,Akiguchi I,Kameyama M,Kimura H

更新日期：1989-04-24 00:00:00

abstract：:Curcumin is capable of promoting peripheral nerve regeneration in normal condition. However, it is unclear whether its beneficial effect on nerve regeneration still exists under diabetic mellitus. The present study was designed to investigate such a possibility. Diabetes in rats was developed by a single dose of strep...

journal_title：Neuroscience letters

authors： Ma J,Yu H,Liu J,Chen Y,Wang Q,Xiang L

更新日期：2016-01-01 00:00:00

abstract：:CaCl2-induced myelopathy was produced in rats by the application of a solution of CaCl2 to exposed leptomeninges of lumbosacral spinal cord. Equal lengths of remote cervical and lumbar cord were removed at intervals following Ca2+ application. The total Ca2+ in tissue from lumbar cord was significantly elevated over a...

journal_title：Neuroscience letters

authors： Happel RD,Banik NL,Balentine JD,Hogan EL

更新日期：1984-08-31 00:00:00

abstract：:Dehydroepiandrosterone sulfate (DHEAS) dose-dependently inhibited [3H]norepinephrine (NE) secretion and the corresponding [Ca2+]i rise induced by the nicotinic receptor agonist 1,1-dimethyl-4-phenylpoperazimium (DMPP) in bovine chromaffin cells. DHEAS at 10 microM, the physiological concentration in human serum, signi...

journal_title：Neuroscience letters

authors： Liu PS,Lin MK,Hsieh HL

更新日期：1996-02-09 00:00:00

abstract：:Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in the human diet. Recently, it is demonstrated to have potent antinociceptive effect. However, little is understood about the mechanism underlying CGA analgesia. Here, we have found that CGA can exert an inhibitory effect on the functional activi...

journal_title：Neuroscience letters

authors： Qu ZW,Liu TT,Qiu CY,Li JD,Hu WP

更新日期：2014-05-01 00:00:00

abstract：:In this study we examined the presence of dopamine D1 receptors in monkey amniotic epithelial cells (MAEC) using RT-PCR and radioligand binding experiments. We found that MAEC express D1 receptor mRNA that is having 99% homology with human dopamine D1 receptors. Saturation binding studies using [3H]SCH-23390 showed a ...

journal_title：Neuroscience letters

authors： Elwan MA,Ishii T,Ono F,Sakuragawa N

更新日期：1999-02-26 00:00:00

abstract：:Almost all of the important pathophysiological targets for ethanol in the nervous system appear to be specific membrane proteins involved in signal transduction. In this paper we have examined levels and functionality of the alpha subunit of the Go protein (Goalpha) in cerebral cortex and cerebellum from rats that hav...

journal_title：Neuroscience letters

authors： Guillén A,García-Villafranca J,Mata F,Homburger V,Castro J

更新日期：2003-12-26 00:00:00