Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy.

Abstract:

:Peripheral nerve damage causes a dramatic alteration to the gene expression in primary sensory neurons, changes within the neuronal cell body giving rise to an altered phenotype, adapted for axonal regeneration. Such changes suggest an alteration in activity, or levels, of cellular transcription factors. The POU family transcription factor Oct-2 is known to be induced in sensory neurons by nerve growth factor (NGF) and might therefore be affected by the removal of target-derived NGF following axotomy. Paradoxically, however, the expression of Oct-2 showed a transient increase of two- to three-fold 24 h after axotomy. In contrast, axotomy had no effect on the levels of the Brn-3 sub-family of POU proteins, indicating that this effect was specific for Oct-2.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Begbie JL,Wood JN,Anderson PN,Latchman DS

doi

10.1016/0304-3940(96)12514-3

subject

Has Abstract

pub_date

1996-04-05 00:00:00

pages

183-6

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304394096125143

journal_volume

207

pub_type

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