Abstract:
:Peripheral nerve damage causes a dramatic alteration to the gene expression in primary sensory neurons, changes within the neuronal cell body giving rise to an altered phenotype, adapted for axonal regeneration. Such changes suggest an alteration in activity, or levels, of cellular transcription factors. The POU family transcription factor Oct-2 is known to be induced in sensory neurons by nerve growth factor (NGF) and might therefore be affected by the removal of target-derived NGF following axotomy. Paradoxically, however, the expression of Oct-2 showed a transient increase of two- to three-fold 24 h after axotomy. In contrast, axotomy had no effect on the levels of the Brn-3 sub-family of POU proteins, indicating that this effect was specific for Oct-2.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Begbie JL,Wood JN,Anderson PN,Latchman DSdoi
10.1016/0304-3940(96)12514-3subject
Has Abstractpub_date
1996-04-05 00:00:00pages
183-6issue
3eissn
0304-3940issn
1872-7972pii
0304394096125143journal_volume
207pub_type
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