当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Depression of spike adaptation and afterhyperpolarization by 4-aminopyridine in hippocampal neurons.

Depression of spike adaptation and afterhyperpolarization by 4-aminopyridine in hippocampal neurons.

Abstract：

:In guinea pig hippocampal slices, 4-aminopyridine (4-AP) in concentrations of 100-500 microM reduced the adaptation of CA3 pyramidal neurons to depolarizing stimuli, resulting in a prolongation of repetitive firing during injection of long-lasting depolarizing currents. Concurrently, there was a decrease in the 'sag' of potential after spike bursts. Furthermore, 4-AP decreased or abolished the hyperpolarizing potential (the afterhyperpolarization) which normally followed repetitive firing of the neurons. The findings suggest that 4-AP could interfere with the Ca2+-activated K+ current in hippocampal CA3 pyramidal neurons.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Matsuda Y,Yoshida S,Fujimura K,Nakamura M

doi

10.1016/0304-3940(86)90281-8

subject

Has Abstract

pub_date

1986-04-24 00:00:00

pages

316-20

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(86)90281-8

journal_volume

65

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • (+)-epi-Clausenamide, but not (-)-epi-clausenamide, showed more potential than (-)-clausenamide on facilitating synaptic transmission in CA1 region of hippocampal synapses.

    abstract：:Effect of (+)-epi-clausenamide and (-)-epi-clausenamide on synaptic transmission in CA1 region of hippocampal slice was compared in this study. (+)-epi-Clausenamide showed more potency than (-)-clausenamide on either induction or maintenance of long term potentiation (LTP). Effect of (+)-epi-clausenamide on potentiati...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.06.049

    authors： Ning N,Sun J,Du G,Han N,Zhang J,Chen N

    更新日期：2012-08-15 00:00:00

  • beta-Endorphin acts on the reproductive tract of female rats to suppress sexual receptivity.

    abstract：:Sexual receptivity was suppressed in female rats immediately after the male had ejaculated. The inhibition was prevented by intravaginal injection of naloxone (100 micrograms) before testing and intravaginal injection of beta-endorphin (1.0 micrograms) inhibited sexual behavior in female rats in a manner comparable to...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(90)90523-c

    authors： Forsberg G,Bednar I,Eneroth P,Södersten P

    更新日期：1990-07-17 00:00:00

  • 'Collapsed' (argyrophilic, dark) neurons in rat model of transient focal cerebral ischemia.

    abstract：:To elucidate the early histopathological changes after transient focal cerebral ischemia, we made 1 h intraluminal occlusion of the middle cerebral artery on rats. After different reperfusion time, from minutes to 3 days, argyrophil III method was used for the demonstration of 'collapsed' (argyrophilic, dark) neurons....

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(93)90562-y

    authors： Czurkó A,Nishino H

    更新日期：1993-11-12 00:00:00

  • Evaluation of driver fatigue on two channels of EEG data.

    abstract：:Electroencephalogram (EEG) data is an effective indicator to evaluate driver fatigue. The 16 channels of EEG data are collected and transformed into three bands (θ, α, and β) in the current paper. First, 12 types of energy parameters are computed based on the EEG data. Then, Grey Relational Analysis (GRA) is introduce...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2011.11.014

    authors： Li W,He QC,Fan XM,Fei ZM

    更新日期：2012-01-11 00:00:00

  • Presynaptic large-conductance calcium-activated potassium channels control synaptic transmission in the superficial dorsal horn of the mouse.

    abstract：:Large-conductance calcium-activated potassium channels (BK channels) have been suggested to play a substantial role in synaptic transmission in the spinal cord dorsal horn. In the present experiments, we attempted to clarify the physiological significance of BK channels in the modulation of synaptic transmission in th...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.08.022

    authors： Furukawa N,Takasusuki T,Fukushima T,Hori Y

    更新日期：2008-10-17 00:00:00

  • Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice.

    abstract：:The pineal product melatonin that acts on specific melatonin receptors has been implicated in pathobiological mechanisms of neuropsychiatric disorders including Alzheimer's disease. We used mice lacking melatonin MT(2) receptors (MT(2) knockouts) to investigate the role of these receptors in synaptic plasticity and le...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.09.040

    authors： Larson J,Jessen RE,Uz T,Arslan AD,Kurtuncu M,Imbesi M,Manev H

    更新日期：2006-01-23 00:00:00

  • 5-Methoxytryptamine is metabolized by monoamine oxidase A in the pineal gland and plasma of golden hamsters.

    abstract：:Pineal concentrations of 5-methoxytryptamine, 5-methoxytryptophol, 5-methoxyindole acetic acid and melatonin were determined using high performance liquid chromatography following administration of different monoamine oxidase (MAO) inhibitors (clorgyline, pargyline and deprenyl) to golden hamsters. Plasma concentratio...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(91)90923-h

    authors： Raynaud F,Pévet P

    更新日期：1991-02-25 00:00:00

  • Sensitization of nociceptors and dorsal horn neurons contributes to pain in sickle cell disease.

    abstract：:Sickle cell disease (SCD) describes a group of disorders associated with a point mutation in the beta chain of hemoglobin. The mutation leads to the creation of sickle hemoglobin (HbS) and causes distortion of erythrocytes through polymerization under low oxygen, resulting in characteristic sickle red blood cells. Vas...

    journal_title：Neuroscience letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.neulet.2019.04.013

    authors： Uhelski ML,Simone DA

    更新日期：2019-07-13 00:00:00

  • The LRRK2 G2019S mutation in a series of Argentinean patients with Parkinson's disease: clinical and demographic characteristics.

    abstract：OBJECTIVES:To determine clinical characteristics and frequency of leucine-rich repeat kinase 2 gene (LRRK2) mutations in a cohort of patients with Parkinson's disease (PD) from Argentina. BACKGROUND:Variation in the LRRK2 gene represents the most common genetic determinant of PD, only few data are available from Latin...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2013.01.011

    authors： Gatto EM,Parisi V,Converso DP,Poderoso JJ,Carreras MC,Martí-Massó JF,Paisán-Ruiz C

    更新日期：2013-03-14 00:00:00

  • Morphological and electrophysiological evidence for axonal regeneration of axotomized cerebellothalamic neurons in kittens.

    abstract：:Against the current concept of abortive regeneration of axotomized neurons in the mammalian central nervous system, the occurrence of remarkable axonal regeneration of cerebellothalamic projection neurons following transection of the decussation of the superior cerebellar peduncle was proved in kittens morphologically...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(81)90093-8

    authors： Kawaguchi S,Miyata H,Kawamura M,Harada Y

    更新日期：1981-08-07 00:00:00

  • In vitro inhibition of vasopressin release in brain by behaviorally relevant ethanol concentrations.

    abstract：:We have investigated the effect of ethanol upon vasopressin (AVP) content in brain and upon in-vitro release of AVP from the rat median eminence. In-vitro ethanol concentrations (5-25 mM), comparable to behaviorally relevant blood ethanol levels, induce a substantial inhibition of AVP release from the median eminence,...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90400-3

    authors： Brinton RE,Gruener R,Deshmukh P,Yamamura HI

    更新日期：1986-06-18 00:00:00

  • Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats.

    abstract：:Several studies demonstrated that Diabetes mellitus (DM) enhances the risk for Alzheimer's disease (AD). Although hyperglycemia and perturbed function of insulin signaling have been proposed to contribute to AD pathogenesis, the molecular mechanisms behind this association is not clear yet. Seladin-1 is an enzyme cata...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2016.09.018

    authors： Kazkayasi I,Ismail MA,Parrado-Fernandez C,Björkhem I,Pekiner C,Uma S,Cedazo-Minguez A,Burul-Bozkurt N

    更新日期：2016-10-28 00:00:00

  • Calcium currents in rat entorhinal cortex layer II stellate and layer III pyramidal neurons in acute brain slice.

    abstract：:The entorhinal cortex (EC) is an essential relay station in neocortical - hippocampal information transfer and memory functions. Layer II stellate and layer III pyramidal neurons show specific damage in Alzheimer's disease and epilepsy, respectively. Using whole cell patch clamp recording in rat brain slices we here d...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)00339-7

    authors： Visan V,Heinemann U,Volynets A,Müller W

    更新日期：2002-07-26 00:00:00

  • Vasoactive intestinal polypeptide receptor-like immunoreactivity in human sweat glands.

    abstract：:Human sweat and sebaceous glands were studied immunohistochemically with a monoclonal antibody recognizing a vasoactive intestinal polypeptide (VIP) receptor. The staining pattern correlated well with the known distribution of sympathetic VIP-containing nerves in the human skin. The luminal cell layer of the sweat gla...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(90)90853-2

    authors： Kummer W,Herbst WM,Heym C

    更新日期：1990-03-14 00:00:00

  • Serotonin-immunoreactive structures in the central nervous system of the garfish Lepisosteus productus (Semionotiformes, Osteichthyes).

    abstract：:Serotonin-immunoreactive (5HT-IR) neurons were investigated in the brain and rostral (cervical) spinal cord of the garfish, a non-teleost actinopterygian. The diencephalon contained a prominent 5HT-IR cell group consisting mainly of liquor-contacting neurons in the hypothalamic periventricular wall. Their ependymofuga...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(98)01011-8

    authors： Chiba A,Oka S

    更新日期：1999-02-12 00:00:00

  • Progesterone and dexamethasone differentially regulate the IGF-system in glial cells.

    abstract：:IGF-1 is an important factor for myelin synthesis and hence possesses therapeutic potential in treating demyelinating disease such as multiple sclerosis. However, IGF-1 poorly crosses the blood-brain barrier. In this study, we investigated the effects of the sex steroid progesterone and the glucocorticoid dexamethason...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.10.051

    authors： Chesik D,De Keyser J

    更新日期：2010-01-14 00:00:00

  • Familial Alzheimer disease associated with A713T mutation in APP.

    abstract：:Mutations in APP are associated with familial early-onset Alzheimer disease (FAD). Examination of the genomic sequence in one patient with FAD revealed a change located in the axon 17 of the APP gene at position 275329G>A (GenBank accession number: D87675; GI: 2429080); cDNA sequence 2137G>A (GenBank accession number:...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2004.08.026

    authors： Armstrong J,Boada M,Rey MJ,Vidal N,Ferrer I

    更新日期：2004-11-11 00:00:00

  • Tactile perception of the roughness of the end of a tool: what role does tool handle roughness play?

    abstract：:We investigated whether the perceived roughness of the end of a tool is influenced by the texture of the handle used to hold it. Participants rated the roughness of the ends (caps) of a series of tools by rubbing them along their forearm, and indicated the perceived roughness of the tool's cap by means of an anchored ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.02.068

    authors： Zampini M,Mawhinney S,Spence C

    更新日期：2006-06-12 00:00:00

  • Neuroprotective effect of epigallocatechin-3-gallate in a mouse model of chronic glaucoma.

    abstract：:Epigallocatechin-3-gallate (EGCG) is a powerful antioxidant with suggested neuroprotective action. This study investigated the protective effects of EGCG against retinal ganglion cells (RGCs) degeneration in an animal model of glaucoma. C57BL/6J mice (n=54) were divided randomly into four groups: normal control group ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2015.06.002

    authors： Shen C,Chen L,Jiang L,Lai TY

    更新日期：2015-07-23 00:00:00

  • Expression analysis of the genes identified in GWAS of the postmortem brain tissues from patients with schizophrenia.

    abstract：:Many gene expression studies have examined postmortem brain tissues of patients with schizophrenia. However, only a few expression studies of the genes identified in genome-wide association study (GWAS) have been published to date. We measured the expression levels of the genes identified in GWAS (ZNF804A, OPCML, RPGR...

    journal_title：Neuroscience letters

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.neulet.2014.03.031

    authors： Umeda-Yano S,Hashimoto R,Yamamori H,Weickert CS,Yasuda Y,Ohi K,Fujimoto M,Ito A,Takeda M

    更新日期：2014-05-07 00:00:00

  • Influence of task difficulty on the features of event-related potential during visual oddball task.

    abstract：:We present a comprehensive analysis of the change in event-related potential (ERP) due to task difficulty during a visual oddball task. Specifically, we investigated the inter-subject difference in difficulty-related change of ERP patterns using single-trial ERP analysis focusing on P300 and P2 components. ERPs were r...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.09.004

    authors： Kim KH,Kim JH,Yoon J,Jung KY

    更新日期：2008-11-14 00:00:00

  • Valproate administration to mice increases histone acetylation and 5-lipoxygenase content in the hippocampus.

    abstract：:Gene expression can be regulated by chromatin remodeling induced by the opposing actions of histone acetyltransferases and histone deacetylases (HDAC). HDAC inhibitors are considered putative anti-cancer drugs, but may also alter gene expression in the brain. Valproic acid (valproate; VPA), a drug used for treatment o...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(03)00490-7

    authors： Yildirim E,Zhang Z,Uz T,Chen CQ,Manev R,Manev H

    更新日期：2003-07-17 00:00:00

  • Intrathecal administration of autologous bone marrow stromal cells improves neuropathic pain in patients with spinal cord injury.

    abstract：:Neuropathic pain (NP) is highly disabling, responds poorly to pharmacological treatment, and represents a significant cause of decreased quality of life in patients suffering from spinal cord injury (SCI). In recent years, cell therapy with autologous mesenchymal stromal cells (MSCs) has been considered as a potential...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2018.01.035

    authors： Vaquero J,Zurita M,Rico MA,Aguayo C,Fernández C,Gutiérrez R,Rodríguez-Boto G,Saab A,Hassan R,Ortega C

    更新日期：2018-03-23 00:00:00

  • Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamine.

    abstract：:The involvement of spinal glial cells in the nociceptive behaviors induced by 800 pmol of histamine was determined in mice. Histamine at 800 pmol injected intrathecally (i.t.) produced nociceptive behaviors, consisting of scratching, biting and licking. The nociceptive behaviors induced by histamine were significantly...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2011.02.038

    authors： Mizoguchi H,Komatsu T,Iwata Y,Watanabe C,Watanabe H,Orito T,Katsuyama S,Yonezawa A,Onodera K,Sakurada T,Sakurada S

    更新日期：2011-05-16 00:00:00

  • Neuropeptide VF-associated satiety involves mu and kappa but not delta subtypes of opioid receptors in chicks.

    abstract：:Neuropeptide VF (NPVF) induces satiety through hypothalamic interactions; however, the central mechanism that mediates these effects is poorly understood. Therefore, this study was conducted to explore some possible opioid receptor associated mechanisms of NPVF-induced satiety using chicks as models. Co-injection of N...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.03.029

    authors： Cline MA,Sliwa LN

    更新日期：2009-05-22 00:00:00

  • Sympathetic nervous system mediates cold stress-induced suppression of natural killer cytotoxicity in rats.

    abstract：:The aim of the present study is to investigate the mechanisms of suppression of splenic natural killer (NK) cytotoxicity caused by cold stress, using 6-hydroxydopamine (6-OHDA) as chemical sympathectomy. The NK activity was measured by (51)chromium release assay. Central sympathectomy with intracerebroventricular inje...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2003.11.007

    authors： Jiang XH,Guo SY,Xu S,Yin QZ,Ohshita Y,Naitoh M,Horibe Y,Hisamitsu T

    更新日期：2004-03-18 00:00:00

  • Lithium decreases turnover of arachidonate in several brain phospholipids.

    abstract：:In vivo rates of incorporation and turnover of palmitate and arachidonate in brain phospholipids were measured in awake rats treated chronically with lithium, following intravenous infusion of radiolabeled palmitate and arachidonate, respectively. Chronic lithium, at a brain level considered to be therapeutic in human...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(96)13264-x

    authors： Chang MC,Grange E,Rabin O,Bell JM,Allen DD,Rapoport SI

    更新日期：1996-12-20 00:00:00

  • Changes in dopamine release in caudate nuclei and substantia nigrae after electrical stimulation of the posterior interposate nucleus of cat cerebellum.

    abstract：:The effect of unilateral electrical stimulation of the posterior interposate nucleus of the cerebellum was examined on the activity of the nigro-striatal dopaminergic pathways on both sides of the brain in alpha-chloralose anaesthetized cats. Push-pull cannulae were inserted into both caudate nuclei and both substanti...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(80)90079-8

    authors： Nieoullon A,Dusticier N

    更新日期：1980-04-01 00:00:00

  • The effectiveness of EEG-feedback on attention, impulsivity and EEG: a sham feedback controlled study.

    abstract：:EEG-feedback, also called neurofeedback, is a training procedure aimed at altering brain activity, and is used as a treatment for disorders like Attention Deficit/Hyperactivity Disorder (ADHD). Studies have reported positive effects of neurofeedback on attention and other dependent variables. However, double-blind stu...

    journal_title：Neuroscience letters

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.neulet.2010.05.026

    authors： Logemann HN,Lansbergen MM,Van Os TW,Böcker KB,Kenemans JL

    更新日期：2010-07-19 00:00:00

  • The dissociable neural dynamics of cognitive conflict and emotional conflict control: An ERP study.

    abstract：:This study investigated differences in the neural time-course of cognitive conflict and emotional conflict control, using event-related potentials (ERPs). Although imaging studies have provided some evidence that distinct, dissociable neural systems underlie emotional and nonemotional conflict resolution, no ERP study...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2016.03.020

    authors： Xue S,Li Y,Kong X,He Q,Liu J,Qiu J

    更新日期：2016-04-21 00:00:00