Calcium currents in rat entorhinal cortex layer II stellate and layer III pyramidal neurons in acute brain slice.

Abstract:

:The entorhinal cortex (EC) is an essential relay station in neocortical - hippocampal information transfer and memory functions. Layer II stellate and layer III pyramidal neurons show specific damage in Alzheimer's disease and epilepsy, respectively. Using whole cell patch clamp recording in rat brain slices we here demonstrate that high voltage activated Ca(2+)-currents (I(Ca)(2+)) are about 1.6-fold bigger in stellate cells than in pyramidal neurons while current density is equal in both cell types. In stellate cells I(Ca)(2+) shows stronger inactivation with depolarization, block of I(Ca)(2+) by Ni(2+) (300 and 600 microM) is more effective, and this block decreases more for currents evoked from a less negative holding potential than in layer III pyramidal neurons. These data indicate distinct molecular composition of Ca(2+)-channels and can partially explain stronger increases of [Ca(2+)](i) during 10 Hz firing activity in EC pyramidal versus stellate neurons.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Visan V,Heinemann U,Volynets A,Müller W

doi

10.1016/s0304-3940(02)00339-7

keywords:

subject

Has Abstract

pub_date

2002-07-26 00:00:00

pages

153-6

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394002003397

journal_volume

327

pub_type

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