Abstract：
:Oxytocin (OT) modulation of synaptic transmission between olfactory bulb neurones has been implicated in the induction of maternal behaviour, but the mechanism of action is unknown. We examined the action of OT on gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated spontaneous inhibitory postsynaptic currents (sIPSCs) in cultured mitral/tufted (M/T) cells with the use of whole-cell patch-clamp recordings. OT reversibly reduced the frequency of sIPSCs without affecting the amplitudes. The effect of OT on sIPSCs was mimicked by the OT receptor agonist [Thr(4), Gly(7)]-OT in a reversible manner and blocked by the OT receptor antagonist desGly-NH(2)(9), d(CH(2))(5)-[Tyr(Me)(2), Thr(4)]-ornithine-vasotocin. OT has no effect, however, on the membrane currents evoked by exogenous application of GABA. These results demonstrate that OT depresses GABA(A) receptor-mediated sIPSCs in M/T cells by a presynaptic mechanism.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Osako Y,Otsuka T,Taniguchi M,Oka T,Kaba Hdoi
10.1016/s0304-3940(00)01235-0keywords:
subject
Has Abstractpub_date
2000-07-28 00:00:00pages
25-8issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(00)01235-0journal_volume
289pub_type
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