Abstract:
:The excitotoxic cell death and the release of gamma-amino-butyric acid (GABA) evoked by excitatory amino acids (EAAs) were comparatively examined in rat cortical sister cultures grown in serum-free (N2) and serum-supplemented (SSM) media. Cell death was induced by 24 h exposure to 1 mM N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) or kainate. [3H]GABA release was evoked by 5 min exposure of preloaded cultures to 0.5 mM NMDA, AMPA or kainate. EAAs evoked remarkable GABA release in both N2 and SSM cultures, but caused toxic cell death in SSM cultures, only. Our findings indicate that functionally active EAA receptors do not necessarily mediate neurotoxicity and suggest that excitotoxicity can be prevented without blocking excitatory transmission.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Erdö SL,Cai N,Lakics Vdoi
10.1016/0304-3940(93)90489-8subject
Has Abstractpub_date
1993-04-02 00:00:00pages
84-6issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90489-8journal_volume
152pub_type
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journal_title:Neuroscience letters
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