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Learning may reduce neurogenesis in adult rat dentate gyrus.

Abstract：

:Neuron production carries on throughout adult life in granule cell layer of mammalian dentate gyrus. The acquisition of a hippocampus-dependent task enhances newborn cell survival in granule cell layer (GCL) during the period in which several newborn cells die. In this paper the effect of learning, occurring after the maximal period of newborn cell death, on newborn cells was investigated. Rats were trained for hippocampus-dependent learning in Morris water maze. 5-bromo-2'-deoxyuridine was administered 8-10 days before training beginning and labeled cells were counted after training. Learning decreased BrdU-labeled cell density in GCL, and increased TUNEL-positive cells. Moreover, learning diminished immature neuron density prevalently in the internal blade of GCL. Therefore, a different effect of learning on immature neuron survival, depending on the time elapsing from mitosis to learning, is suggested.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Ambrogini P,Orsini L,Mancini C,Ferri P,Ciaroni S,Cuppini R

doi

10.1016/j.neulet.2003.12.123

keywords:

subject

Has Abstract

pub_date

2004-04-08 00:00:00

pages

13-6

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

S0304394004000163

journal_volume

359

pub_type

杂志文章

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