Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor.

abstract：:In the hypothalamus of androgen-insensitive testicular feminized (Tfm) mice the normal pattern of immunohistochemical staining for glial fibrillary acidic protein (GFAP) is markedly different from normal. Along the borders of the third ventricle and in the dorsomedial and arcuate nuclei, the numbers of stained astrocy...

journal_title：Neuroscience letters

authors： McQueen JK,Wright AK,Arbuthnott GW,Fink G

更新日期：1990-10-02 00:00:00

abstract：:Loss of ganglion cells is a common and irreversible complication of hair cell loss in the cochlea. Gene transfer could potentially be used to prevent this neuronal degeneration and other pathologies in the cochlea. Human adenoviruses should provide a feasible gene transfer vehicle for transducing the quiescent cochlea...

journal_title：Neuroscience letters

authors： Raphael Y,Frisancho JC,Roessler BJ

更新日期：1996-03-29 00:00:00

abstract：:Integrin-associated protein (IAP) is normally localized to the synapse rich plexiform layers of the mammalian retina. In other neuronal systems, IAP and its ligand, P84, have been implicated in synaptic function. Previously, an abnormal distribution of P84 was noted in the IAP-null retina. To examine the potential rol...

journal_title：Neuroscience letters

authors： Ball SL,Lindberg FP,Lagenaur CF,Peachey NS

更新日期：2001-02-02 00:00:00

abstract：:Generalized epilepsy with febrile seizures plus (GEFS(+)) is a common familial epilepsy syndrome, which generally develops in childhood. GEFS(+) is caused by mutations in the sodium-channel α1-subunit (SCN1A). In this report, we investigated a Chinese family with an autosomal dominant form of GEFS(+). The affected GEF...

journal_title：Neuroscience letters

authors： Cui X,Zeng F,Liu Y,Zhang J,Archacki S,Zhan T,Du R,Tang Z,Liu J,Wang QK,Liu M

更新日期：2011-09-26 00:00:00

abstract：:Three dopamine receptor mRNAs were detected by reverse polymerase chain reaction in the rat forebrain during ontogeny. The D1 receptor mRNA gave a faint signal from gestational day 11 (G11) on, while the D1b receptor was not detectable before G12. The D3 receptor mRNA was slightly expressed at G11 and clearly present ...

journal_title：Neuroscience letters

authors： Cadoret MA,Jaber M,Bloch B

更新日期：1993-05-28 00:00:00

abstract：:We have used light microscopic autoradiography to localize differentially Type 1 and 2 benzodiazepine receptors using pharmacologic and detergent treatment techniques. The triazolopyridazine CL218872 has preferential affinity for Type 1 receptors from which it displaces [3H]flunitrazepam selectivity. In biochemical ex...

journal_title：Neuroscience letters

authors： Lo MM,Niehoff DL,Kuhar MJ,Snyder SH

更新日期：1983-08-19 00:00:00

abstract：BACKROUND:A relatively small number of genetic variants are implicated to pathophysiology of intracerebral hemorrhage (ICH). Aquaporin-4 (AQP4) has been reported to be implicated in the pathophysiological processes of ICH development. OBJECTIVE:To examine the role of AQP4 gene region polymorphisms on the ICH risk. ME...

journal_title：Neuroscience letters

authors： Dardiotis E,Siokas V,Marogianni C,Aloizou AM,Sokratous M,Paterakis K,Dardioti M,Grigoriadis S,Brotis A,Kapsalaki E,Fountas K,Jagiella J,Hadjigeorgiou GM

更新日期：2019-03-23 00:00:00

abstract：:Excitatory amino acid (EAA) receptor-mediated events have recently been implicated in dopaminergic mechanisms of neurotoxicity. 2,4,5-Trihydroxyphenylalanine (6-hydroxy-DOPA, TOPA), the ortho-hydroxylated derivative of the dopamine precursor 2,4-dihydroxyphenylalanine (L-DOPA), has recently been reported to have neuro...

journal_title：Neuroscience letters

authors： Cha JH,Dure LS IV,Sakurai SY,Penney JB,Young AB

更新日期：1991-10-28 00:00:00

abstract：:To examine whether the Haken-Kelso-Bunz model for rhythmic interlimb coordination applies to walking side-by-side on a treadmill, we invited six pairs of participants to coordinate their stepping movements at seven prescribed relative phases (between 0 degrees and 180 degrees ) to scan the attractor layout governing t...

journal_title：Neuroscience letters

authors： van Ulzen NR,Lamoth CJ,Daffertshofer A,Semin GR,Beek PJ

更新日期：2010-04-26 00:00:00

abstract：:Influences of a submaximal endurance test in the right first dorsal interosseus on force and fatigue-related parameters of activating the contralateral muscle were studied. The test consisted of a 30% maximum voluntary contraction (MVC), regularly interrupted by maximal contractions and brief rest periods. Despite the...

journal_title：Neuroscience letters

authors： Zijdewind I,Zwarts MJ,Kernell D

更新日期：1998-08-28 00:00:00

abstract：BACKROUND:8-hydroxy-2 deoxyguanosine (8-OHdG) and the 8-hydroxyguanosine (8-OHG) are the most widely used biomarkers of nucleoside oxidation affecting DNA and RNA and are considered reliable markers of oxidative stress. Increased levels of these markers are found in the various biological fluids of patients with neurod...

journal_title：Neuroscience letters

authors： Gmitterová K,Gawinecka J,Heinemann U,Valkovič P,Zerr I

更新日期：2018-01-01 00:00:00

abstract：:Nicotine is known to stimulate energy expenditure, although the precise mechanism is unclear. To clarify the involvement of corticotropin-releasing factor (CRF) in the mechanism by which nicotine increases energy expenditure, the effect of intraperitoneal injection of nicotine (0.1 or 0.5mg/kg) on the release of norad...

journal_title：Neuroscience letters

authors： Mano-Otagiri A,Iwasaki-Sekino A,Ohata H,Arai K,Shibasaki T

更新日期：2009-05-08 00:00:00

abstract：:Leucine-rich glioma inactivated 3 (LGI3) is a member of LGI/epitempin (EPTP) family. The biological function of LGI3 and its association with disease are not known. We previously reported that mouse LGI3 was highly expressed in brain in a developmentally and transcriptionally regulated manner. In this study, we identi...

journal_title：Neuroscience letters

authors： Park WJ,Lee SE,Kwon NS,Baek KJ,Kim DS,Yun HY

更新日期：2008-10-31 00:00:00

abstract：BACKGROUND:Chronic postoperative pain (CPOP) is a common clinical problem which might be related to central sensitization. It has been widely accepted that NMDA (N-methyl-D-aspartate) receptors are among the triggers of central sensitization. Ketamine is a non-competitive NMDA receptor antagonist that is widely used in...

journal_title：Neuroscience letters

authors： Shen Y,Xu L,Liu M,Lei Y,Gu X,Ma Z

更新日期：2016-03-11 00:00:00

abstract：:Quantitative receptor autoradiography was used to study dopamine (DA) receptors in dorsal striatum and its projection regions in brains from individuals dying with Huntington's disease (HD) and controls. Heterogeneous loss of both D1 and D2 receptors was present in the striatum of early and late stage HD brains. The d...

journal_title：Neuroscience letters

authors： Richfield EK,O'Brien CF,Eskin T,Shoulson I

更新日期：1991-10-28 00:00:00

abstract：:gamma-Interferon (IFN-gamma) is known to induce expression of major histocompatibility complex (MHC) class II antigens on murine astrocytes and MHC class I antigens on murine oligodendrocytes. We studied whether the human IFN-gamma could induce the expression of Human Leukocyte Antigen (HLA)-A, B, C and -DR antigens o...

journal_title：Neuroscience letters

authors： Hirayama M,Yokochi T,Shimokata K,Iida M,Fujiki N

更新日期：1986-12-23 00:00:00

abstract：:Glufosinate ammonium, a structural analogue of glutamate, is an active herbicidal ingredient. The neuronal activities of this compound were investigated by use of a microdialysis system that allowed us to measure nitric oxide production in the rat cerebellum in vivo. Kainate (0.3-30 nmol/10 microliter), N-methyl-D-asp...

journal_title：Neuroscience letters

authors： Nakaki T,Mishima A,Suzuki E,Shintani F,Fujii T

更新日期：2000-09-01 00:00:00

abstract：:Aromatic L-amino acid decarboxylase (AADC) decarboxylates L-DOPA and 5-hydroxytryptophan into dopamine and serotonin, respectively. Starting from a rat AADC cDNA clone isolated in our laboratory, we produced a beta-galactosidase-AADC fusion protein in E. coli. It was purified from inclusion bodies and injected into a ...

journal_title：Neuroscience letters

authors： Krieger M,Tillet Y,Gros F,Thibault J

更新日期：1993-04-16 00:00:00

abstract：:The present study investigated one of the characteristics of No-go-related brain activity during somatosensory Go/No-go paradigms, by manipulating the stimulus site and response hand. Somatosensory event-related potentials (ERPs) were recorded in ten right-handed subjects. Electrical stimulation was delivered to the s...

journal_title：Neuroscience letters

authors： Nakata H,Sakamoto K,Kakigi R

更新日期：2010-07-12 00:00:00

abstract：:Several studies have suggested that the activity of nitric oxide synthase (NOS) may be involved in the regulation of food intake in the genetically obese Zucker rats. In the present study, we investigated the expression of NOS in various hypothalamic regions of obese and lean Zucker rats using nicotinamide adenine din...

journal_title：Neuroscience letters

authors： Kim MJ,Kim Y,Choe BK,Kim SA,Lee HJ,Kim JW,Huh Y,Kim C,Chung JH

更新日期：2000-09-29 00:00:00

abstract：:Super-resolution microscopy techniques offer subdiffraction limited resolution that is two- to ten-fold improved compared to that offered by conventional confocal microscopy. This breakthrough in resolution for light microscopy has contributed to new findings in neuroscience and synapse biology. This review will focus...

journal_title：Neuroscience letters

authors： Badawi Y,Nishimune H

更新日期：2020-01-10 00:00:00

abstract：:The anti-neuroinflammatory effect of Astragaloside IV (ASI) has been reported, but its underlying mechanisms are unclear. This study is further to explore the underlying mechanism of ASI on anti-neuroinflammatory effect in LPS induced microglia cells. The result showed ASI significantly reduced the production of infla...

journal_title：Neuroscience letters

authors： Li C,Yang F,Liu F,Li D,Yang T

更新日期：2018-02-14 00:00:00

abstract：:TRPA1 agonists cinnamaldehyde (CA) and mustard oil (allyl isothiocyanate=AITC) induce heat hyperalgesia and mechanical allodynia in human skin, and sensitize responses of spinal and trigeminal dorsal horn neurons to noxious skin heating in rats. TRPA1 is also implicated in cold nociception. We presently used behaviora...

journal_title：Neuroscience letters

authors： Tsagareli MG,Tsiklauri N,Zanotto KL,Carstens MI,Klein AH,Sawyer CM,Gurtskaia G,Abzianidze E,Carstens E

更新日期：2010-04-12 00:00:00

abstract：:In recent years, several attempts have been made to identify biochemical and/or genetic markers which might have diagnostic and prognostic uses for Alzheimer's disease (AD). To look for possible new blood markers, a longitudinal study was carried out in our Central Nervous System Biomedical Research Center between Oct...

journal_title：Neuroscience letters

authors： Lombardi VR,Cacabelos R

更新日期：1999-01-22 00:00:00

abstract：:Cultured rat pheochromocytoma cells, PC-12, were found to contain renin-like activity. The activity which was inhibited by monospecific antibodies to rat renal renin showed a pH optimum between 6 and 7, indicating that it was a specific renin. The cells also contained angiotensin I and angiotensin I converting enzyme....

journal_title：Neuroscience letters

authors： Okamura T,Clemens DL,Inagami T

更新日期：1984-05-04 00:00:00

abstract：:Ibotenic acid was injected into 3 parts of the lateral rat hippocampus. The animals were sacrificed 100 days after treatment, and studied immunohistochemically. The lesioned side of the hippocampus was highly atrophic with extensive neuronal loss and gliosis. Although silver staining revealed no particular structures ...

journal_title：Neuroscience letters

authors： Nakamura Y,Takeda M,Niigawa H,Hariguchi S,Nishimura T

更新日期：1992-02-17 00:00:00

abstract：:The time course of the event related potentials evoked within a delayed matching to sample task employing verbal and pictorial stimuli was analyzed with a source reconstruction method (minimum norm method). During signal stimulus presentation pictorial stimuli evoked more activity than verbal stimuli. Activity was par...

journal_title：Neuroscience letters

authors： Dobel C,Hauk O,Zobel E,Eulitz C,Pulvermüller F,Cohen R,Schönle PW,Elbert T,Rockstroh B

更新日期：1998-09-11 00:00:00

abstract：:Perceptions of facial attractiveness are sensitive to emotional expression of the perceived face. However, little is known about whether the emotional expression on the face of another observer of the perceived face may have an effect on perceptions of facial attractiveness. The present study used event-related potent...

journal_title：Neuroscience letters

authors： Huang Y,Pan X,Mo Y,Ma Q

更新日期：2016-03-23 00:00:00

abstract：:We investigated glutamate-induced neuron response in the ventral nerve cord of the earthworm (Eisenia foetida) using a voltage-sensitive dye-imaging technique. Isolated earthworm ganglia were stained by fluorescence voltage-sensitive dye, RH414, and voltage image was acquired by a conventional charge-coupled device (C...

journal_title：Neuroscience letters

authors： Oka K,Ogawa H,Fujita S

更新日期：1994-09-26 00:00:00

abstract：:Tenascin-R (TN-R) is a neural specific protein and an important molecule involved in inhibition of axonal regeneration after spinal cord injury (SCI). Here we report on rabbit-derived TN-R polyclonal antibody, which acts as a TN-R antagonist with high titer and high specificity, promoted neurite outgrowth and sproutin...

journal_title：Neuroscience letters

authors： You J,Hong SQ,Zhang MY,Zhao HL,Liu TZ,Zhou HL,Cai YQ,Xu ZM,Guo Y,Jiang XD,Xu RX

更新日期：2012-09-13 00:00:00