Abstract:
:Integrin-associated protein (IAP) is normally localized to the synapse rich plexiform layers of the mammalian retina. In other neuronal systems, IAP and its ligand, P84, have been implicated in synaptic function. Previously, an abnormal distribution of P84 was noted in the IAP-null retina. To examine the potential role of IAP in the function of the retinal outer plexiform layer, we recorded electroretinograms (ERGs) from IAP-null mice and wild-type littermates. Under a wide range of stimulus conditions, there was no difference between the responses of these two groups, including ERG components that reflect post-receptoral activity. These results indicate that IAP and/or P84 may not be critical for the development and maintenance of the photoreceptor-to-bipolar cell synapse.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ball SL,Lindberg FP,Lagenaur CF,Peachey NSdoi
10.1016/s0304-3940(00)01743-2keywords:
subject
Has Abstractpub_date
2001-02-02 00:00:00pages
111-4issue
2eissn
0304-3940issn
1872-7972pii
S0304394000017432journal_volume
298pub_type
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