Electroretinograms remain normal in mice lacking a synapse associated protein.

Abstract:

:Integrin-associated protein (IAP) is normally localized to the synapse rich plexiform layers of the mammalian retina. In other neuronal systems, IAP and its ligand, P84, have been implicated in synaptic function. Previously, an abnormal distribution of P84 was noted in the IAP-null retina. To examine the potential role of IAP in the function of the retinal outer plexiform layer, we recorded electroretinograms (ERGs) from IAP-null mice and wild-type littermates. Under a wide range of stimulus conditions, there was no difference between the responses of these two groups, including ERG components that reflect post-receptoral activity. These results indicate that IAP and/or P84 may not be critical for the development and maintenance of the photoreceptor-to-bipolar cell synapse.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Ball SL,Lindberg FP,Lagenaur CF,Peachey NS

doi

10.1016/s0304-3940(00)01743-2

keywords:

subject

Has Abstract

pub_date

2001-02-02 00:00:00

pages

111-4

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304394000017432

journal_volume

298

pub_type

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