Abstract:
:Cultured rat pheochromocytoma cells, PC-12, were found to contain renin-like activity. The activity which was inhibited by monospecific antibodies to rat renal renin showed a pH optimum between 6 and 7, indicating that it was a specific renin. The cells also contained angiotensin I and angiotensin I converting enzyme. Angiotensin II/III were also detected in lysate. These findings indicated an intrinsic pathway of angiotensin formation in pheochromocytoma. The formation of angiotensins in pheochromocytoma cells suggests modulating functions of angiotensin on neurotransmitter release from adrenal medulla.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Okamura T,Clemens DL,Inagami Tdoi
10.1016/0304-3940(84)90433-6subject
Has Abstractpub_date
1984-05-04 00:00:00pages
151-6issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(84)90433-6journal_volume
46pub_type
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