K+ currents of human T-lymphocytes are unaffected by Alzheimer's disease and amyloid beta protein.

abstract：:The present study aimed at investigating the effects of an artificial head position-based tongue-placed electrotactile biofeedback on postural control during quiet standing under different somatosensory conditions from the support surface. Eight young healthy adults were asked to stand as immobile as possible with the...

journal_title：Neuroscience letters

authors： Vuillerme N,Pinsault N,Chenu O,Demongeot J,Payan Y,Danilov Y

更新日期：2008-02-06 00:00:00

abstract：:Previous studies have demonstrated that isoflurane, a commonly used volatile anesthetic, can induce widespread apoptosis in the neonatal animal brains and result in persistent cognitive impairment. Isoflurane-induced cytosolic Ca(2+) overload and activation of mitochondrial pathway of apoptosis may be involved in this...

journal_title：Neuroscience letters

authors： Li Y,Wang F,Liu C,Zeng M,Han X,Luo T,Jiang W,Xu J,Wang H

更新日期：2013-06-17 00:00:00

abstract：:We investigated the mRNA expression of the various complement components in cultured mouse microglia and astrocytes by the reverse transcription and polymerase chain reaction. C1q, C2, C3, and C4 mRNAs were detected in microglial cultures. C3 and C4 mRNAs were found in astrocyte cultures. Microglia showed enhanced exp...

journal_title：Neuroscience letters

authors： Haga S,Aizawa T,Ishii T,Ikeda K

更新日期：1996-10-04 00:00:00

abstract：:Adult filum terminale (FT) is an atypical region from where multipotent neural progenitor cells (NPCs) have been isolated. However, poor neuronal differentiation rate of FT-NPCs currently limits their clinical applications. Using custom-designed electric fields (EFs), this study sets up a method to significantly impro...

journal_title：Neuroscience letters

authors： Dong ZY,Pei Z,Li Z,Wang YL,Khan A,Meng XT

更新日期：2017-06-09 00:00:00

abstract：:Glucose metabolism and tricarboxylic acid cycle (TCA) kinetics have been shown to decline in brain with age in various animal species. This study examined TCA cycle kinetics and age in Brown-Norway Fischer 344 rats. Using [1-(13)C]glucose infused over 10, 30, 60 or 100 min, and following the label through the TCA cycl...

journal_title：Neuroscience letters

authors： Perron JT,Tyson RL,Sutherland GR

更新日期：2000-03-10 00:00:00

abstract：:The mouse dopamine D4 receptor gene was isolated from a genomic DNA library by plaque hybridization. The D4 receptor gene encoded an open reading frame consisting of 387 amino acids, interrupted by three introns. Distribution of the D4 receptor mRNA in brain regions and peripheral tissues of mice was examined by rever...

journal_title：Neuroscience letters

authors： Suzuki T,Kobayashi K,Nagatsu T

更新日期：1995-10-13 00:00:00

abstract：:The use of the cobalt technique is limited by the fact that cobaltous ions travel within axons for a shorter distance than do other intracellular markers. In the present experiments different organic cobaltous complexes were tested in the rat's sciatic nerve. Cobaltous complexes containing ornithine, threonine, lysine...

journal_title：Neuroscience letters

authors： Gallyas F,Lénárd L,Lázár G

更新日期：1978-09-01 00:00:00

abstract：:We have studied nicotinic acetylcholine receptors in spontaneously hypertensive 'stroke prone' (SHsp) rats. We found a significant decrease in 125I-alpha-bungarotoxin binding and alpha7 subunit mRNA levels in cortical areas of the SHsp rats with respect to Wistar Kyoto (WKy) normotensive rats. Antihypertensive drug tr...

journal_title：Neuroscience letters

authors： Ferrari R,Frasoldati A,Leo G,Torri C,Zini I,Agnati LF,Zoli M

更新日期：1999-12-31 00:00:00

abstract：:C57 black mice given a single injection of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 40 mg/kg, developed marked reduction of striatal dopamine content and loss of dopaminergic neurons in the zona compacta of the substantia nigra. However, pretreatment with any one of four different antioxidants, alpha-tocop...

journal_title：Neuroscience letters

authors： Perry TL,Yong VW,Clavier RM,Jones K,Wright JM,Foulks JG,Wall RA

更新日期：1985-09-30 00:00:00

abstract：:Kynurenic acid (KYNA) is an antagonist of (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors and it blocks the glycine site of the NMDA receptor preferentially (IC50 = 7.9 microM). KYNA is produced endogenously by transamination of its precursor L-kynurenin...

journal_title：Neuroscience letters

authors： Scharfman HE,Hodgkins PS,Lee SC,Schwarcz R

更新日期：1999-10-22 00:00:00

abstract：:Intra- and extracellular recordings from the in vitro rat hippocampal slice preparation have been used to investigate the influence of serotoninergic, adrenergic and cholinergic receptor antagonists on the excitability of CA1 pyramidal neurones. The serotonin receptor antagonist 4-amino-N-(1-azabicyclo[2.2.2]oct-3yl)-...

journal_title：Neuroscience letters

authors： Siarey RJ,Andreasen M,Lambert JD

更新日期：1995-10-27 00:00:00

abstract：:Functional recovery after experimental stroke in rats is enhanced by environmental enrichment by stimulating plastic changes in brain regions outside the lesion, but the molecular mechanisms are not known. We investigated the effect of environmental enrichment after focal cerebral ischemia on cognitive recovery and hi...

journal_title：Neuroscience letters

authors： Rönnbäck A,Dahlqvist P,Svensson PA,Jernås M,Carlsson B,Carlsson LM,Olsson T

更新日期：2005-09-09 00:00:00

abstract：:Nogo-A has been identified as an inhibitory molecule to neurite outgrowth after injury in adult mammalian central nervous system (CNS). The C-terminal fragment of Nogo-A, Nogo-66, inhibits axonal regrowth through NgR1 signaling. Residues 1-32 of Nogo-66 cover two regions that contribute most affinity of Nogo-66 to NgR...

journal_title：Neuroscience letters

authors： Deng Q,Cai W,Li S,Su B

更新日期：2013-03-01 00:00:00

abstract：:Several clinical and epidemiological studies suggest that Alzheimer's disease (AD) and vascular dementia share common risk factors. Oxidative stress is one of these well recognized factors. It can result from an excess of free-radical activity and impaired antioxidant defenses. Paraoxonase (PON1), a component of high ...

journal_title：Neuroscience letters

authors： Helbecque N,Cottel D,Codron V,Berr C,Amouyel P

更新日期：2004-03-18 00:00:00

abstract：:Mutations in the glucocerebrosidase gene (GBA) have recently been associated with an increased risk of Parkinson disease (PD). GBA mutations have been observed to be particularly prevalent in the Ashkenazi Jewish population. Interestingly, this population also has a high incidence of the Lrrk2 p.G2019S mutation which ...

journal_title：Neuroscience letters

authors： Nishioka K,Vilariño-Güell C,Cobb SA,Kachergus JM,Ross OA,Wider C,Gibson RA,Hentati F,Farrer MJ

更新日期：2010-06-21 00:00:00

abstract：:Contraction of the isolated tracheal strip to capsaicin was prevented by chronic denervation of the tissue. Tetrodotoxin, hyoscine and hexamethonium caused no inhibition of the response, suggesting that tetrodotoxin-resistant terminal portions of non-cholinergic nerves were activated in this way. There was a strong co...

journal_title：Neuroscience letters

authors： Szolcsányi J

更新日期：1983-11-21 00:00:00

abstract：:Deposition of amyloid beta (A beta) is one of the pathological hallmarks of brains affected with Alzheimer's disease (AD). The accumulation of A beta have been observed in human myopathies with rimmed vacuoles (RVs) which might involve lysosomal function. Chloroquine, a potent lysosomotropic agent, induces muscle path...

journal_title：Neuroscience letters

authors： Tsuzuki K,Fukatsu R,Takamaru Y,Kimura K,Abe M,Shima K,Fujii N,Takahata N

更新日期：1994-12-05 00:00:00

abstract：:The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has been reported to be a candidate gene for susceptibility to Parkinson's disease (PD), but results of different studies are conflicting. Here, we conducted a meta-analysis of published case-control studies to evaluate the association between MTHFR C677T and A...

journal_title：Neuroscience letters

authors： Liu L,Zhang L,Guo L,Yu Q,Li H,Teng J,Xie A

更新日期：2018-01-01 00:00:00

abstract：:Noradrenaline in the central nervous system plays an important role in regulating physiological functions, and is a key mechanistic component of general anesthesia. The purpose of this present study was to determine if nitrous oxide and xenon modulate noradrenaline release in the cerebral cortex. We performed a series...

journal_title：Neuroscience letters

authors： Yoshida H,Kushikata T,Tose R,Kudo M,Kudo T,Hirota K

更新日期：2010-01-22 00:00:00

abstract：:A late hyperpolarization (LH) which follows low level to moderate synaptic stimulation of neurons in the hippocampal formation neurons was previously shown to consist primarily of a potassium conductance. The present experiments showed that when extracellular cesium was present in order to reduce anamolous rectificati...

journal_title：Neuroscience letters

authors： Thalmann RH

更新日期：1984-04-20 00:00:00

abstract：:We have found an APOE epsilon 4 allelic frequency of 0.289 (95% CI 0.195-0.383) in Spanish AD patients (n = 88; average age = 71.2 +/- 9.37) and of 0.061 (95% CI 0.023-0.099) in age-matched controls (n = 147; average age = 71.5 +/- 10.29). Remarkably no ApoE 4/4 subjects were observed in any of the age-matched control...

journal_title：Neuroscience letters

authors： Adroer R,Santacruz P,Blesa R,López-Pousa S,Ascaso C,Oliva R

更新日期：1995-04-21 00:00:00

abstract：:Neurotrophin 3 (NT3) is a potent neurotrophic factor for promoting remyelination and recovery of neuronal function; upregulation of its expression in the central nervous system (CNS) is thus of major therapeutic importance for neurological deficits. Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix S...

journal_title：Neuroscience letters

authors： Zhang ML,Zhang XJ,Kang J,Zhang HJ,Chen XL,Liu N,Liu SQ,Ma WD,Zhang GX,Zhu L

更新日期：2017-05-10 00:00:00

abstract：:Presentation of two different tones at two different time periods each under two different types (14C or 3H) of 2-deoxyglucose (2-DG) produced two bands of labelling in the inferior colliculus (IC) of a guinea pig. Filtering tests revealed that both bands were produced by only one of the labels (14C). Four guinea pigs...

journal_title：Neuroscience letters

authors： Webster WR,Servière J,Martin R,Hartley E

更新日期：1983-10-10 00:00:00

abstract：:The topographical relations among the terminal field of spinothalamic fibers and the cells projecting upon areas 4 and 5 were studied in the anterior intralaminar nuclei of the cat. Terminals anterogradely labeled from the spinal cord and cell populations retrogradely labeled from the lateral pericruciate and anterior...

journal_title：Neuroscience letters

authors： Molinari M,Bentivoglio M,Minciacchi D,Granato A,Macchi G

更新日期：1986-12-23 00:00:00

abstract：:To investigate the effect of bilateral low-frequency repetitive transcranial magnetic stimulation (rTMS) over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor (BDNF) and serotonin (5-HT) in patients with generalized anxiety disorders (GAD). As compared with before treatment, the HARS score in p...

journal_title：Neuroscience letters

authors： Lu R,Zhang C,Liu Y,Wang L,Chen X,Zhou X

更新日期：2018-09-25 00:00:00

abstract：:Human low back pain sometimes originates from lumbar facet joints. In human lumbar facet joint inflammation or degeneration, the referred pain is not only expanded into the low back area but also into the leg or foot. The rat L5-L6 facet joint is innervated by the L1-L5 dorsal root ganglia. The presence of brain-deriv...

journal_title：Neuroscience letters

authors： Ohtori S,Takahashi K,Moriya H

更新日期：2002-04-26 00:00:00

abstract：:It has been shown that the incidence of cognitive impairment increases with the severity of chronic kidney disease (CKD). A previous study has demonstrated that hippocampal oxidative stress contributes to cognitive dysfunction in CKD model mice. Endoplasmic reticulum (ER) stress is thought to contribute significantly ...

journal_title：Neuroscience letters

authors： Kosuge Y,Osada N,Shimomura A,Miyagishi H,Wada T,Ishige K,Shimba S,Ito Y

更新日期：2018-06-11 00:00:00

abstract：:The hypothesis involving glutamate in the neuropathology of schizophrenia has attracted great interest. Several studies report dysfunctions in glutamatergic systems, including alterations in kainate and N-methyl-D-aspartate (NMDA) receptors in various areas, as well as changes in the number of glutamate uptake sites. ...

journal_title：Neuroscience letters

authors： Aparicio-Legarza MI,Cutts AJ,Davis B,Reynolds GP

更新日期：1997-08-22 00:00:00

abstract：:Online shopping festivals play a significant role in consumers' purchase decision and have been the focus of much research and many marketing practices. However, research has yet to explore which product categories can promote consumer purchase intention during online shopping festivals. This study carried out a neuro...

journal_title：Neuroscience letters

authors： Shang Q,Jin J,Qiu J

更新日期：2020-01-10 00:00:00

abstract：:Previous studies have shown that striatum and nucleus accumbens (NAc) are two different structures in mediating addictive drug-induced ascorbic acid (AA) release. In order to further characterize the different effects of drugs-induced AA release in the striatum and NAc, in the present study, we investigated the effect...

journal_title：Neuroscience letters

authors： Gu PF,Wu CF,Yang JY,Shang Y,Hou Y,Bi XL,Dai F

更新日期：2006-05-15 00:00:00