Valproic acid promotes neuronal differentiation by induction of neuroprogenitors in human bone-marrow mesenchymal stromal cells.

abstract：:This study investigated the effects of ketamine on fluoxetine-induced antidepressant behavior using the forced swimming test (FST) in mice. In order to understand the possible role of N-methyl-d-aspartate (NMDA) neurotransmission in the antidepressant effect of fluoxetine, different groups of mice (n=10) were administ...

journal_title：Neuroscience letters

authors： Owolabi RA,Akanmu MA,Adeyemi OI

更新日期：2014-04-30 00:00:00

abstract：:A major goal in the study of motor learning is to improve the extent to which subjects adapt their movements in response to errors. Recent attention has focused on the gradual-adaptation paradigm, in which an adaptive stimulus is introduced incrementally, rather than all at once as in conventional adaptation paradigms...

journal_title：Neuroscience letters

authors： Wong AL,Shelhamer M

更新日期：2011-08-18 00:00:00

abstract：:The effect of antagonists on N-methyl-D-aspartate (NMDA)-induced response was investigated in isolated nucleus tractus solitarii (NTS) neurons freshly isolated from the rat using a conventional pathclamp technique. The NMDA-induced inward current consisted of an initial peak followed by a steady-state component. The c...

journal_title：Neuroscience letters

authors： Nakagawa T,Shirasaki T,Tateishi N,Murase K,Akaike N

更新日期：1990-05-31 00:00:00

abstract：:Nuclear factor kappa B (NF(kappa)B) transcription factor plays a key role in the expression of many genes involved in the inflammatory process. We used the Freund's Complete Adjuvant (FCA)-induced model of peripheral inflammation to investigate the anti-inflammatory effects of double stranded oligodeoxynucleotides (OD...

journal_title：Neuroscience letters

authors： Igwe OJ

更新日期：2005-06-10 00:00:00

abstract：:This study evaluates the potential neuroprotective properties of amburoside A, a glucoside isolated from Amburana cearensis, on rat mesencephalic cell cultures exposure to the neurotoxin 6-hydroxydopamine (6-OHDA). The parameters determined were cell viability by the 3[4,5-dimethylthiazole-2-il]-2,5-diphenyltetrazoliu...

journal_title：Neuroscience letters

authors： Leal LK,Nobre Júnior HV,Cunha GM,Moraes MO,Pessoa C,Oliveira RA,Silveira ER,Canuto KM,Viana GS

更新日期：2005-11-11 00:00:00

abstract：:In man, an anesthetic agent that induces surgical anesthesia with minimal influence on descending pyramidal tract activity remains to be found. Anesthesia with ketamine allows recording of stable compound muscle action potentials (CMAPs) to single transcranial magnetic stimulations of the motor cortex (CortStim) in mo...

journal_title：Neuroscience letters

authors： Kothbauer K,Schmid UD,Liechti S,Rösler KM

更新日期：1993-05-14 00:00:00

abstract：:The insular cortex (IC) processes multimodal sensory information including gustatory, visceral, nociceptive, and thermal sensation, and is considered to play a role in the regulation of homeostasis. The IC receives dense histaminergic projection from the tuberomamillary nucleus in the hypothalamus, and recent studies ...

journal_title：Neuroscience letters

authors： Takei H,Song L,Ebihara K,Shirakawa T,Koshikawa N,Kobayashi M

更新日期：2012-06-14 00:00:00

abstract：:The regional cerebral blood flow (rCBF) was measured with positron emission tomography in eight normal volunteers with the purpose of measuring rCBF changes related to the comprehension of an unfamiliar spoken languages. When attempting to comprehend the meaning of words, the left hemisphere showed dominant increases ...

journal_title：Neuroscience letters

authors： Kawashima R,Itoh M,Hatazawa J,Miyazawa H,Yamada K,Matsuzawa T,Fukuda H

更新日期：1993-10-14 00:00:00

abstract：:Muscarinic cholinoreceptors regulate the neurosecretion process in vertebrate neuromuscular junctions. The diversity of muscarinic effects on acetylcholine (ACh) secretion may be attributed to the different muscarinic subtypes involved in this process. In the present study, the location of five muscarinic receptor sub...

journal_title：Neuroscience letters

authors： Tsentsevitsky AN,Kovyazina IV,Nurullin LF,Nikolsky EE

更新日期：2017-05-10 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1), an insulinotropic peptide secreted from enteroendocrine cells, has been known to have a neuroprotective effect. However, it is not fully understood the intracellular mediator of GLP-1 signaling in neuronal cells. In the present study, we examined the change in intracellular signaling o...

journal_title：Neuroscience letters

authors： Nakajima S,Numakawa T,Adachi N,Yoon HS,Odaka H,Ooshima Y,Kunugi H

更新日期：2016-03-11 00:00:00

abstract：:In this study the effect of memantine, an antagonist at the N-methyl-D-aspartate receptor, on spatial learning deficit and on neuronal damage following transient cerebral ischemia was evaluated. Global ischemia was induced by four-vessel-occlusion (4VO) for 20 min in rats. Memantine was administered 20 min before indu...

journal_title：Neuroscience letters

authors： Block F,Schwarz M

更新日期：1996-04-12 00:00:00

abstract：:A trait locus for electroencephalographic photoparoxysmal response (PPR) has been mapped to the chromosomal region 6p21 near a susceptibility locus for juvenile myoclonic epilepsy (JME). Linkage disequilibrium mapping revealed strong associations between JME and polymorphisms of the gene encoding the bromodomain-conta...

journal_title：Neuroscience letters

authors： Lorenz S,Taylor KP,Gehrmann A,Becker T,Muhle H,Gresch M,Tauer U,Sander T,Stephani U

更新日期：2006-05-29 00:00:00

abstract：:In this article, we investigated the autophosphorylation and translocation of calcium/calmodulin-dependent protein kinase II alpha (CaMKII alpha) in hippocampus during global ischemia. The following results were observed: (1) CaMKII alpha immediately became autophosphorylated after 3 min ischemia, at the same time, th...

journal_title：Neuroscience letters

authors： Meng F,Zhang G

更新日期：2002-11-15 00:00:00

abstract：:Benzodiazepine (Bzd) agonist, diazepam (Dzp) and inverse agonist methyl beta-carboline-3-carboxylate (beta-CCM); acetylcholinesterase inhibitor, physostigmine (Physo) and muscarinic antagonist, scopolamine (Scopo), were investigated for their mnesic effect in a passive avoidance (PA) task in rats. Impairments were obs...

journal_title：Neuroscience letters

authors： Anglade F,Bizot JC,Dodd RH,Baudoin C,Chapouthier G

更新日期：1994-12-05 00:00:00

abstract：:gamma-Aminobutyric acidA (GABA(A)) gated chloride ion channels were expressed from human recombinant cDNA using the baculovirus/Sf-9 insect cell expression system. The electrophysiological effects in whole-cell currents of 5-(4-piperidyl) isoxazol-3-ol (4-PIOL), a GABA(A) receptor partial agonist, were investigated on...

journal_title：Neuroscience letters

authors： Westh-Hansen SE,Noguchi K,Witt MR,Murai Y,Nielsen M,Akaike N

更新日期：1997-07-11 00:00:00

abstract：:Rapid removal of synaptically released glutamate from the extracellular space ensures a high signal-to-noise ratio in excitatory neurotransmission. In the cerebellum, glial glutamate transporters, GLAST and GLT-1, are co-localized in the processes of Bergmann glia wrapping excitatory synapses on Purkinje cells (PCs). ...

journal_title：Neuroscience letters

authors： Takatsuru Y,Iino M,Tanaka K,Ozawa S

更新日期：2007-06-08 00:00:00

abstract：:The distribution of neurons expressing beta-endorphin immunoreactivity was explored in the brain of adult jerboa during two distinct periods characterizing its reproductive cycle. A large presence of cell bodies displaying beta-endorphin immunoreactivity occured within different parts of the mediobasal hypothalamus al...

journal_title：Neuroscience letters

authors： El Ouezzani S,Tramu G,Magoul R

更新日期：2005-03-11 00:00:00

abstract：:By means of light microscopic autoradiography, binding sites for the gamma-aminobutyric acid (GABA) analogues, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol ([7-3H]THIP), [3H]isoguvacine and [3H]baclofen were found on many cultured cerebellar and spinal neurons of fetal and newborn rats. The number of neurons labelle...

journal_title：Neuroscience letters

authors： Hösli E,Krogsgaard-Larsen P,Hösli L

更新日期：1985-10-24 00:00:00

abstract：:'Reverspectives' (by artist Patrick Hughes) consist of truncated pyramids with their small faces closer to the viewer, allowing realistic scenes to be painted on them. Because their pictorial perspective reverses the physical depth arrangement, reverspectives provide a bistable paradigm of two radically different, com...

journal_title：Neuroscience letters

authors： Wagner M,Ehrenstein WH,Papathomas TV

更新日期：2009-01-09 00:00:00

abstract：:To elucidate the mechanisms of individual differences in pain and analgesic sensitivity, we analyzed the variable number of tandem repeat polymorphism in the third exon of the dopamine D4 receptor gene. Alleles that were less than four repeats long and four or more repeats long were considered Short and Long, respecti...

journal_title：Neuroscience letters

authors： Aoki Y,Nishizawa D,Kasai S,Fukuda K,Ichinohe T,Yamashita S,Ikeda K

更新日期：2013-05-10 00:00:00

abstract：:beta-Bungarotoxin (BuTx)-binding cells were immunocytochemically examined in the developing rat cerebellum. The tissue was incubated with BuTx and then immunostained with antiserum against its toxoid. On postnatal day 6, only Golgi cells were positive for immunoreaction. Immunoreactive Golgi cells were reduced in numb...

journal_title：Neuroscience letters

authors： Katoh-Semba R,Semba R,Kashiwamata S

更新日期：1987-04-23 00:00:00

abstract：:In order to study the rapidity of interaction between tetraethylammonium (TEA) and the delayed K+ channel of the mammalian brain neuron, TEA was applied to isolated rat hippocampal pyramidal neurons in a time-controlled sequence with a voltage step using a concentration clamp technique. TEA at a concentration of 30 mM...

journal_title：Neuroscience letters

authors： Oyama Y,Harata N,Akaike N

更新日期：1991-10-14 00:00:00

abstract：:There are numerous polymorphisms within the tau gene but these are in complete linkage disequilibrium and exist as two common extended haplotypes H1 and H2. We have investigated the frequency of these haplotypes in 83 cases of sporadic Alzheimer's disease (AD) using the +34 polymorphism in intron 11 of the tau gene as...

journal_title：Neuroscience letters

authors： Green EK,Thaker U,McDonagh AM,Iwatsubo T,Lambert JC,Chartier-Harlin MC,Harris JM,Pickering-Brown SM,Lendon CL,Mann DM

更新日期：2002-05-17 00:00:00

abstract：:The aim of the study was to investigate whether repetitive/temporal hypoxia up-regulated P-glycoprotein (P-gp) in cultured rat brain microvascular endothelial cells (rBMECs). Cultured rBMECs were used as in vitro blood brain barrier (BBB) model. Cells reached confluence were subjected to temporal hypoxic exposure. Und...

journal_title：Neuroscience letters

authors： Xiao-Dong L,Zhi-Hong Y,Hui-Wen Y

更新日期：2008-02-27 00:00:00

abstract：:The neurotoxicant MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), administered to male or female mice, decreased striatal dopamine content and increased the levels of the astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP). The rise in GFAP was evident as early as two days following th...

journal_title：Neuroscience letters

authors： Reinhard JF Jr,Miller DB,O'Callaghan JP

更新日期：1988-12-19 00:00:00

abstract：:The antinociceptive action of cannabinoids in acute and inflammatory pain states have been well-documented. There is also accumulating evidence suggesting that cannabinoids are effective analgesics in chronic pain conditions. WIN 55,212-2, a mixed CB1 and CB2 cannabinoid receptor agonist, has been shown to be effectiv...

journal_title：Neuroscience letters

authors： Ulugol A,Karadag HC,Ipci Y,Tamer M,Dokmeci I

更新日期：2004-11-23 00:00:00

abstract：:A previous study suggested that adults with greater motor difficulties demonstrated less adaptation under a regular error feedback schedule (gain=1:1) but reached a similar level of adaptation compared to controls when feedback was enhanced (gain=1:2). In light of these findings, the present study examined inter-limb ...

journal_title：Neuroscience letters

authors： Bo J,Lee CM

更新日期：2017-07-27 00:00:00

abstract：:Cytoplasmic acidification in taste receptor cells is thought to be involved, at least in part, in acid taste transduction. Since in taste buds about 20% of the receptor cells are electrically coupled, we have tested whether reduction in intracellular pH affects these lateral synaptic interactions. By applying the patc...

journal_title：Neuroscience letters

authors： Bigiani A,Roper SD

更新日期：1994-08-01 00:00:00

abstract：:Transcranial pulsed current stimulation (tPCS) is a non-invasive brain stimulation technique that employs weak, pulsed current at different frequency ranges, inducing electrical currents that reach cortical and subcortical structures. Very little is known about its effects on brain oscillations and functional connecti...

journal_title：Neuroscience letters

authors： Castillo Saavedra L,Morales-Quezada L,Doruk D,Rozinsky J,Coutinho L,Faria P,Perissinotti I,Wang QM,Fregni F

更新日期：2014-08-08 00:00:00

abstract：:Reduction of non-protein-bound iron (NPBI) using iron chelators may attenuate hypoxia-ischemia-induced reperfusion injury of the brain. This study investigated whether administration of low-dose deferoxamine and allopurinol, both having NPBI-chelating properties, reduced hypoxia-ischemia-induced NPBI formation in plas...

journal_title：Neuroscience letters

authors： Shadid M,Buonocore G,Groenendaal F,Moison R,Ferrali M,Berger HM,van Bel F

更新日期：1998-05-22 00:00:00