Effects of 5-(4-piperidyl) isoxazol-3-ol (4-PIOL), a GABA(A) receptor partial agonist, on recombinant human GABA(A) receptors.

abstract：:Neuromelanin (NM)-containing dopaminergic neurons in the substantia nigra are selectively vulnerable in Parkinson's disease (PD), suggesting the involvement of NM in the pathogenesis. NM is composed of protein, lipid, trace metals and melanin component, a mixture of eumelanin produced from dopamine (DA)-quinone and ph...

journal_title：Neuroscience letters

authors： Naoi M,Yi H,Maruyama W,Inaba K,Shamoto-Nagai M,Akao Y,Gerlach M,Riederer P

更新日期：2009-11-13 00:00:00

abstract：:Adenosine has been proposed to be a chemical link between cerebral metabolism and blood flow. In the present study, we investigated whether the intravenous or intracarotid administration of adenosine could influence regional cerebral blood flow in anesthetized rabbits. The study was performed with the [14C]ethanol tis...

journal_title：Neuroscience letters

authors： Puiroud S,Pinard E,Miller MC,Seylaz J

更新日期：1987-09-23 00:00:00

abstract：INTRODUCTION:The saccadic paradigm has been used to investigate specific cortical networks involving attention. The behavioral and electrophysiological investigations of the SEM contribute significantly to the understanding of attentive patterns presented of neurological and psychiatric disorders and sports performance...

journal_title：Neuroscience letters

authors： Bittencourt J,Machado S,Teixeira S,Schlee G,Salles JI,Budde H,Basile LF,Nardi AE,Cagy M,Piedade R,Sack AT,Velasques B,Ribeiro P

更新日期：2012-08-15 00:00:00

abstract：:Plasminogen belongs to the plasminogen activator system of cell signaling proteins and has recently been identified to bind to pathological prion protein PrPSC, but not to its normal conformer, PrPC. Plasminogen binds specifically to the urokinase-type plasminogen activator receptor (uPAR) to promote pericellular prot...

journal_title：Neuroscience letters

authors： Deininger MH,Trautmann K,Magdolen V,Luther T,Schluesener HJ,Meyermann R

更新日期：2002-05-10 00:00:00

abstract：:Ischemic preconditioning is considered to be the most robust endogenous neuroprotectant. However, the conventional ischemic preconditioning protocol is both invasive and impractical to apply. The aim of the present study was to evaluate whether preconditioning with +Gz centrifuge acceleration (head-to-foot inertial lo...

journal_title：Neuroscience letters

authors： Sang H,Li J,Liu J,Wang Z,Huo T,Sun J,Xiong L

更新日期：2008-11-07 00:00:00

abstract：:The presence of serotonin (5-HT)-like immunoreactivity has been detected in ganglionar cell bodies of the nodose ganglia of the cat, using the peroxidase-antiperoxidase immunohistochemical method, applied to sections of ganglia previously embedded in paraffin. The antibodies were raised in rabbits following injection ...

journal_title：Neuroscience letters

authors： Gaudin-Chazal G,Portalier P,Barrit MC,Puizillout JJ

更新日期：1982-11-30 00:00:00

abstract：:In the rat, unilateral intrastriatal injection of monoclonal antibodies to acetylcholinesterase (AChE) produced ipsilateral disappearance of AChE-positive nerve terminals within striatum and adjacent cortex. No alterations in striatal staining patterns were observed for tyrosine hydroxylase, somatostatin, neuropeptide...

journal_title：Neuroscience letters

authors： Bean AJ,Xu Z,Chai SY,Brimijoin S,Hökfelt T

更新日期：1991-11-25 00:00:00

abstract：:We evaluated long-term dynorphin A-immunoreactivity in the rat area postrema (AP) after the administration of cisplatin. First, rats were given 1, 5 and 10mg/kg body weight cisplatin (i.p.) and their behavior was monitored for 72h. We observed a delayed increase in pica 24-72h after injection, compared to the 24h befo...

journal_title：Neuroscience letters

authors： Tsukamoto G,Ichikawa H,Kobashi M,Yamada Y,Kikuchi T,Mese H,Sasaki A

更新日期：2007-09-07 00:00:00

abstract：:The cellular location of kappa-opioid binding sites in the guinea pig cerebellum has been investigated. kappa-Opioid sites were labelled using [3H]ethylketocyclazocine in the presence of mu- and delta-blocking ligands. In vitro autoradiography demonstrated that this kappa-opioid binding was localized predominantly in ...

journal_title：Neuroscience letters

authors： Bunn SJ,Wilkin GP

更新日期：1988-01-11 00:00:00

abstract：:The possibility that arterial baroreceptors may be involved in the potentiation of vasopressin or oxytocin secretion observed after noxious stimuli was tested in male rats after sino-aortic denervation (SAD). There was no significant difference in plasma level of vasopressin or oxytocin between the SAD and the corresp...

journal_title：Neuroscience letters

authors： Onaka T,Yagi K

更新日期：1991-11-25 00:00:00

abstract：:The biological clock of the suprachiasmatic nuclei drives numerous physiological and behavioural circadian rhythms. In this study, we addressed the question as to whether different components of the clock may control separately various circadian functions. Using the rat transpineal microdialysis tool, we analysed the ...

journal_title：Neuroscience letters

authors： Tritschler L,Saboureau M,Pévet P,Bothorel B

更新日期：2006-03-20 00:00:00

abstract：:Single photon-induced transient currents, called quantum bumps were stimulated by short flashes in dark-adapted ventral nerve photoreceptors of Limulus. Flash intensities were set to activate 3 or more bumps. In most cases, current bumps were activated with a constant rate. The frequency of bump occurrence was between...

journal_title：Neuroscience letters

authors： Nagy K

更新日期：1992-09-14 00:00:00

abstract：:In 16 rats, the extensor digitorum longus (EDL) - a fast muscle - was grafted, complete with its innervation, into the bed of the (removed) soleus - a slow muscle. Following the transposition, performed on one side only, EDL recovered and showed the contraction time of the contralateral EDL that served as control. How...

journal_title：Neuroscience letters

authors： Gutmann E

更新日期：1976-07-01 00:00:00

abstract：:Substance P (SP) stimulates striatal dopamine outflow through a cholinergic muscarinic link. SP-induced increase in acetylcholine (Ach) is concentration-dependent, whereas the stimulation of dopamine outflow is seen only over a limited concentration range. M(1) and M(2) receptor stimulation has opposite effects on dop...

journal_title：Neuroscience letters

authors： Khan S,Whelpton R,Michael-Titus AT

更新日期：2000-11-03 00:00:00

abstract：:The psychophysiological basis of problem size effect in the arithmetical processing of additions and subtractions was studied with event-related brain potentials (ERP). Subjects were presented sequences of seven numbers, and ERPs elicited to the sixth number were analyzed. Two variables were manipulated: operation typ...

journal_title：Neuroscience letters

authors： Núñez-Peña MI,Honrubia-Serrano ML,Escera C

更新日期：2005-01-03 00:00:00

abstract：:Using antibodies to somatostatin in combination with the avidin-biotin immunohistochemical method, the laminar distribution and morphology of somatostatin-like (SOM-L) immunoreactive cells have been studied in the hippocampal formation of the rat. SOM-L positive cells are present throughout the longitudinal axis of th...

journal_title：Neuroscience letters

authors： Köhler C,Chan-Palay V

更新日期：1982-12-31 00:00:00

abstract：:In this study, we aimed to investigate whether self-reported mild traumatic brain injury (mTBI) was associated with decreased AD-vulnerable cortical thickness, and to assess the relationship between AD-vulnerable cortical thickness and AD-related biomarker in the Alzheimer's Disease Neuroimaging Initiative subjects. W...

journal_title：Neuroscience letters

authors： Wang ML,Wei XE,Yu MM,Li PY,Li WB,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2017-08-10 00:00:00

abstract：:The present study was designed to investigate the role of the interaction of pentobarbital with gamma-aminobutyric acid (GABA)ergic drugs acting on the Cl(-)-adenosine triphosphate (ATP)ase activity of the plasma membranes fraction of bream brain. The preincubation and then incubation of the membranes with pentobarbit...

journal_title：Neuroscience letters

authors： Menzikov S,Menzikova O

更新日期：2002-12-16 00:00:00

abstract：:Drebrin has been known to act on actin filaments at dendritic spines to cause morphological change, and might be related to the plasticity of synaptic transmission. In the present study, changes of drebrin were examined immunohistochemically in the spinal motoneurons of rats following unilateral sciatic nerve transect...

journal_title：Neuroscience letters

authors： Kobayashi S,Shirao T,Sasaki T

更新日期：2001-10-05 00:00:00

abstract：:Several lines of evidence suggest that dopamine exerts a chronic inhibitory action on GABAergic cells in the striatum, and striatal glutamic acid decarboxylase (GAD) mRNA levels are increased after ipsilateral dopaminergic denervation. In the present study we have used GAD immunocytochemistry to assess whether dopamin...

journal_title：Neuroscience letters

authors： Segovia J,Armstrong DM,Benzing WC,Hornby PJ

更新日期：1991-01-28 00:00:00

abstract：:In vivo differential pulse voltammetry with carbon fiber electrodes was used to monitor extracellular 5-hydroxyindoleacetic acid (5-HIAA) levels in a serotonergic denervated target area, the striatum, before and after transplantation of mesencephalic raphé nuclei into the lateral ventricle in the rat. The amplitude of...

journal_title：Neuroscience letters

authors： McRae-Degueurce A,Serrano A,Sandillon F,Privat A,Scatton B

更新日期：1984-07-27 00:00:00

abstract：:ATP is an important extracellular messenger in the CNS. In the hippocampus, a brain structure relevant for learning and memory processes, it acts both as a modulator and as a mediator of synaptic transmission, with implications for synaptic plasticity phenomena. Recent evidence suggests that ATP modulates activity-dep...

journal_title：Neuroscience letters

authors： da Silva BM,de Mendonça A,Ribeiro JA

更新日期：2005-08-05 00:00:00

abstract：:Using renal arteries from young (6 months), mature (18 months) and old (70 months) rabbits, the effect of dopamine on 3',5'-cyclic adenosine monophosphate (cAMP) generation was studied. No significant differences in basal adenylate cyclase values were found in homogenates of renal artery from young, mature or old rabb...

journal_title：Neuroscience letters

authors： Amenta F,Cavallotti C,Collier WL,Iacopino L

更新日期：1984-10-26 00:00:00

abstract：:Expression levels of amyloid beta (Abeta)-degrading enzymes, insulin degrading enzyme (IDE) and neprilysin (NEP), were examined in transgenic mice with Alzheimer's disease-like neuropathology. After the development of first Abeta plaques in transgenic mice brain, cortical mRNA and protein levels of IDE were significan...

journal_title：Neuroscience letters

authors： Vepsäläinen S,Hiltunen M,Helisalmi S,Wang J,van Groen T,Tanila H,Soininen H

更新日期：2008-06-20 00:00:00

abstract：:Abnormal neural activity generated at a site of nerve injury is thought to contribute to the development of dysaesthesia. Vanilloid receptor 1 (TRPV1), a transducer of noxious stimuli, may be involved in the initiation of this abnormal activity and could provide a useful therapeutic target. We investigated the effect ...

journal_title：Neuroscience letters

authors： Biggs JE,Yates JM,Loescher AR,Clayton NM,Robinson PP,Boissonade FM

更新日期：2008-09-26 00:00:00

abstract：:There have been reports of regional differences in the activation of mitogen activated protein kinases (MAPKs) and in the induction of immediate early genes after electroconvulsive shock (ECS) in the rat brain. This study was performed to determine whether ECS induce the region-specific phosphorylation of MAPK-downstr...

journal_title：Neuroscience letters

authors： Ahn YM,Kang UG,Oh SW,Juhnn YS,Joo YH,Park JB,Kim YS

更新日期：2002-08-23 00:00:00

abstract：:Substance P (SP) plays an important role in sensitization of spinal cord neurons. In this study, we investigated SP-induced calcium activities in cultured rat spinal cord neurons with confocal laser scanning microscopy. Our results showed that SP increased [Ca(2+)](i) by calcium entry rather than release from intracel...

journal_title：Neuroscience letters

authors： Zhou ZS,Shu YS,Zhao ZQ

更新日期：2000-06-16 00:00:00

abstract：:The periaqueductal gray (PAG) is involved in motor activities, such as movements of the neck, back and hind limbs, cardiovascular regulation, micturition, vocalization, and mating behavior, as well as in nociception control. To accomplish these functions the PAG uses information from other parts of the limbic system, ...

journal_title：Neuroscience letters

authors： Mouton LJ,VanderHorst VG,Holstege G

更新日期：1997-11-28 00:00:00

abstract：:Presentation of two different tones at two different time periods each under two different types (14C or 3H) of 2-deoxyglucose (2-DG) produced two bands of labelling in the inferior colliculus (IC) of a guinea pig. Filtering tests revealed that both bands were produced by only one of the labels (14C). Four guinea pigs...

journal_title：Neuroscience letters

authors： Webster WR,Servière J,Martin R,Hartley E

更新日期：1983-10-10 00:00:00

abstract：:Neural stem cells (NSCs) persist in the mammalian brain throughout life and protect against hypoxia-ischemia injury. NSCs are being increasingly recognized as a novel therapeutic target for various neurological disorders. Previous research indicates that miR-21 attenuates hypoxia-ischemia induced apoptotic death in va...

journal_title：Neuroscience letters

authors： Chen R,Tai Y,Zhang Y,Wang L,Yang Y,Yang N,Ma S,Xue F,Wang J

更新日期：2019-01-18 00:00:00