Abstract:
:By means of light microscopic autoradiography, binding sites for the gamma-aminobutyric acid (GABA) analogues, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol ([7-3H]THIP), [3H]isoguvacine and [3H]baclofen were found on many cultured cerebellar and spinal neurons of fetal and newborn rats. The number of neurons labelled by [3H]THIP was considerably smaller than that by the other two radioligands. Unlabelled THIP, GABA and bicuculline methiodide inhibited binding of [3H]THIP and [3H]isoguvacine, whereas binding of [3H]baclofen was inhibited by unlabelled GABA and baclofen but not by bicuculline methiodide. Our results indicate that cultured cerebellar and spinal neurons possess both GABAA and GABAB binding sites and that [3H]THIP possibly binds to a subclass of GABAA receptors.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hösli E,Krogsgaard-Larsen P,Hösli Ldoi
10.1016/0304-3940(85)90417-3subject
Has Abstractpub_date
1985-10-24 00:00:00pages
153-7issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(85)90417-3journal_volume
61pub_type
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(83)90444-5
更新日期:1983-06-30 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2016-05-04 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11608-y
更新日期:1995-06-02 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.05.014
更新日期:2006-08-14 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.03.021
更新日期:2011-05-02 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2015.04.004
更新日期:2015-05-19 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(85)90598-1
更新日期:1985-10-10 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2018-04-03 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.04.025
更新日期:2008-06-20 00:00:00
abstract::The first psychotic episode is classically viewed as a critical period which management is important in determining the long-term outcome of the schizophrenia (SCZ). For this reason, the duration of untreated illness (DUI), defined as the interval between the onset of the psychiatric disorder and the administration of...
journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2016.10.003
更新日期:2018-03-16 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01045-4
更新日期:2000-05-12 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)13463-2
更新日期:1997-03-14 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90037-7
更新日期:1988-12-05 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00675-8
更新日期:1999-11-05 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.09.063
更新日期:2012-11-21 00:00:00
abstract::A comparison of the effect of fatigue caused by electrical induction or voluntary contraction on Ia inhibition in human soleus muscle was investigated in fourteen healthy male subjects. The Hoffmann reflex (H reflex) was employed to elucidate the contribution of fatigue induced contraction to the Ia inhibition. A stat...
journal_title:Neuroscience letters
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3940(95)11883-x
更新日期:1995-09-01 00:00:00
abstract::Rats with suprachiasmatic nuclei (SCN) lesions did not show increased sleep after triazolam (TRZ) injections at any dose from 0.2 to 1.6 mg/kg, whereas 0.4 mg/kg TRZ given intact rats in the middle of their activity phase significantly increased sleep. Across SCN-lesioned and intact rats, the amount of sleep before an...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90007-g
更新日期:1991-04-29 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.02.063
更新日期:2013-06-07 00:00:00
abstract::Pentobarbital anesthesia causes about a 10-fold increase in the antinociceptive potency of beta-endorphin microinjected into the periaqueductal gray (PAG) region of the rat brain. The antinociceptive response to PAG morphine was markedly attenuated during anesthesia, but returned as the rats regained consciousness. As...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(92)90063-d
更新日期:1992-11-09 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00164-0
更新日期:1999-04-02 00:00:00
abstract::To investigate potential trophic actions of extracellular ATP in human astrocytes, we have examined mitogenic signaling by purinergic receptors in cultures prepared from first trimester rostral central nervous system tissue. We found that ATP and ATPgammaS, a hydrolysis-resistant analog, stimulated DNA synthesis, ther...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(98)00067-6
更新日期:1998-02-20 00:00:00
abstract::The effects of morphine (0.2-200 micrograms/kg) administered into the brain stem via a vertebral artery on the somatosympathetic A- and C-reflexes evoked in a cardiac sympathetic nerve by electrical stimulation of somatic myelinated (A) and unmyelinated (C) afferent nerve fibers in anesthetized cats were examined. The...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(92)90916-u
更新日期:1992-04-27 00:00:00
abstract::To study zinc (Zn) mobility in the rat olfactory tract, brain distribution of 65Zn after injection into the olfactory bulb or amygdaloid nuclei was analyzed by autoradiography. Twenty-four hours after 65Zn injection into the olfactory bulb, 65Zn was distributed in the ipsilateral piriform cortex, amygdaloid nuclei and...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00181-x
更新日期:1997-03-28 00:00:00
abstract::The psychostimulant amphetamine (AMPH) is known to act as an indirect dopamine agonist by promoting dopamine release. Here we demonstrate direct AMPH inhibition of field potentials and Na+ currents in rat nucleus accumbens (NAc) neurons. The experiments were done with field potential recordings from NAc slices and who...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(98)00556-4
更新日期:1998-08-07 00:00:00
abstract::Cyclins are regulatory proteins of the cell cycle which bind and activate kinases. In gliomas, contrary to many malignancies, cyclin D1 is rarely amplified, but together with other cyclins, it increases with anaplasia. In a series of 23 surgical biopsies of grade II and III oligodendroglioma, cyclin D1, E, A, B1, CDK4...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00615-3
更新日期:2003-08-21 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90543-4
更新日期:1986-12-23 00:00:00
abstract::Day-night variations of gastrin releasing peptide (GRP) in the neuronal somal area of the SCN and the nearby region on the anterior hypothalamic area (AHA) where GRP fibers project, were examined by semiquantitative immunocytochemistry, and compared with those of vasoactive intestinal peptide (VIP). Both in the SCN an...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90585-1
更新日期:1994-11-07 00:00:00
abstract::Alzheimer's disease (AD) is characterized by the presence of beta-amyloid (Abeta) protein deposits in the brain and increased Abeta (1-42) peptide production is thought to be one of the early events in the pathogenesis of AD that leads to progressive neurodegenerative processes and dementia. Using cDNA subtraction and...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01197-6
更新日期:2000-07-07 00:00:00
abstract::Silent synapses display no excitatory post-synaptic currents (EPSCs) at resting potentials, but can conduct at depolarized potentials. In the hippocampal CA1 region of young animals, conversion of silent synapses to functional synapses occurs rapidly after pairing post-synaptic depolarization with 1Hz pre-synaptic sti...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.02.035
更新日期:2007-04-24 00:00:00