Effects of aging on neuromagnetic mismatch responses to pitch changes.

Abstract:

:Although aging-related alterations in the auditory sensory memory and involuntary change discrimination have been widely studied, it remains controversial whether the mismatch negativity (MMN) or its magnetic counterpart (MMNm) is modulated by physiological aging. This study aimed to examine the effects of aging on mismatch activity to pitch deviants by using a whole-head magnetoencephalography (MEG) together with distributed source modeling analysis. The neuromagnetic responses to oddball paradigms consisting of standards (1000 Hz, p=0.85) and deviants (1100 Hz, p=0.15) were recorded in healthy young (n=20) and aged (n=18) male adults. We used minimum norm estimate of source reconstruction to characterize the spatiotemporal neural dynamics of MMNm responses. Distributed activations to MMNm were identified in the bilateral fronto-temporo-parietal areas. Compared to younger participants, the elderly exhibited a significant reduction of cortical activation in bilateral superior temporal guri, superior temporal sulci, inferior fontal gyri, orbitofrontal cortices and right inferior parietal lobules. In conclusion, our results suggest an aging-related decline in auditory sensory memory and automatic change detection as indexed by MMNm.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Cheng CH,Baillet S,Hsiao FJ,Lin YY

doi

10.1016/j.neulet.2013.02.063

subject

Has Abstract

pub_date

2013-06-07 00:00:00

pages

20-4

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(13)00257-7

journal_volume

544

pub_type

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