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Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons.

Abstract：

:Magnetic resonance imaging was used to investigate the relation between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and volumetric measurements for the medial temporal lobe structures (amygdala, hippocampus, and parahippocampal gyrus) and prefrontal sub-regions (the superior frontal gyrus, middle frontal gyrus, inferior frontal gyrus, ventral medial prefrontal cortex, orbitofrontal cortex, and straight gyrus) in a Japanese sample of 33 schizophrenia patients and 29 healthy subjects. For the controls, the Met carriers had significantly smaller parahippocampal and left superior frontal gyri than the Val homozygotes. The schizophrenia patients carrying the Met allele had a significantly smaller right parahippocampal gyrus than those with the Val/Val genotype, but the genotype did not affect the prefrontal regions in schizophrenia patients. These findings might reflect different genotypic effects of BDNF on brain morphology in schizophrenia patients and healthy controls, implicating the possible role of the brain morphology as an endophenotype for future genetic studies in schizophrenia.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Takahashi T,Suzuki M,Tsunoda M,Kawamura Y,Takahashi N,Tsuneki H,Kawasaki Y,Zhou SY,Kobayashi S,Sasaoka T,Seto H,Kurachi M,Ozaki N

doi

10.1016/j.neulet.2008.02.004

subject

Has Abstract

pub_date

2008-04-11 00:00:00

pages

34-9

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(08)00175-4

journal_volume

435

pub_type

杂志文章

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