Abstract:
:The efficacy of acetylcholine muscarinic M2 receptor-G protein coupling was investigated in Alzheimer's disease and control neocortical membranes by measuring the effects of MgCl2 and 5'-guanylylimidodiphosphate (Gpp[NH]p) on high-affinity [3H]oxotremorine-M ([3H]OXO-M) binding. MgCl2 gave similar enhancements of [3H]OXO-M binding in Alzheimer's disease and control occipital cortex. In contrast, MgCl2 enhanced [3H]OXO-M binding was significantly higher in Alzheimer's disease superior temporal cortex, compared to controls. MgCl2 enhanced [3H]OXO-M binding in both the occipital and temporal cortices of the Alzheimer's disease cases was reversed to control levels by Gpp[NH]p. It is concluded that the number of high-affinity muscarinic M2 sites is increased in Alzheimer's disease superior temporal, but not occipital, cortex and that M2 sites in both regions maintain an efficient G-protein coupling.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hérnandez-Hérnandez A,Adem A,Ravid R,Cowburn RFdoi
10.1016/0304-3940(95)11281-zsubject
Has Abstractpub_date
1995-02-15 00:00:00pages
57-60issue
1eissn
0304-3940issn
1872-7972pii
030439409511281Zjournal_volume
186pub_type
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