Contribution of mGluR1 to the basal activity of a mouse cerebellar Purkinje neuron.

abstract：:Imagining a familiar environment is different from imagining an environmental map and clinical evidence demonstrated the existence of double dissociations in brain-damaged patients due to the contents of mental images. Here, we assessed a large sample of young and old participants by considering their ability to gener...

journal_title：Neuroscience letters

authors： Piccardi L,Nori R,Palermo L,Guariglia C,Giusberti F

更新日期：2015-08-18 00:00:00

abstract：:Interleukin-1beta (IL1beta) peripheral activities are mediated by type I IL1 receptors (IL1RI), whereas type II IL1 receptors (IL1RII) act as 'decoy' targets. To study the functionality of IL1RII in the brain, mice were treated with an intracerebroventricular injection of a neutralising MoAb directed against IL1RII (4...

journal_title：Neuroscience letters

authors： Cremona S,Layé S,Dantzer R,Parnet P

更新日期：1998-04-24 00:00:00

abstract：:Both substance P (SP)- and epinephrine-containing neurons in the rostral ventrolateral medulla have been thought to play a role in regulating vasomotor tone. The combination of retrograde transport of a fluorescent dye (Fast Blue) and immunofluorescent staining for SP- and phenylethanolamine-N-methyltransferase (PNMT)...

journal_title：Neuroscience letters

authors： Lorenz RG,Saper CB,Wong DL,Ciaranello RD,Loewy AD

更新日期：1985-04-19 00:00:00

abstract：:In our horseradish peroxidase (HRP) study of the afferents to the medullary raphe nuclei in the cat, HRP uptake by damaged axons en route to the inferior olive (IO) was thought to be responsible for retrograde labelling of specific midbrain nuclei. To control for such indirect labelling, HRP was injected iontophoretic...

journal_title：Neuroscience letters

authors： Abols IA,Basbaum AI

更新日期：1979-07-01 00:00:00

abstract：:The aim of this study was to clarify whether 12-lipoxygenase (12-LOX) activation was involved in reactive oxygen species (ROS) generation, extensive poly(ADP-ribose) polymerase (PARP) activation and neuronal death induced by glucose-deprivation, followed by glucose-reload (GD/R). The decrease of neuronal viability and...

journal_title：Neuroscience letters

authors： Nagasawa K,Kakuda T,Higashi Y,Fujimoto S

更新日期：2007-12-18 00:00:00

abstract：:This study was designed to investigate the effects of honokiol, a neuroprotective agent, on cerebral edema in cerebral ischemia reperfusion (IR) mice and its mechanism of anti-inflammation. Honokiol (0.7-70μg/kg) significantly reduced brain water contents and decreased the exudation of Evans blue dye from brain capill...

journal_title：Neuroscience letters

authors： Zhang P,Liu X,Zhu Y,Chen S,Zhou D,Wang Y

更新日期：2013-02-08 00:00:00

abstract：:Purinoceptor agonists produced potassium currents with the order of potency: ATP > adenosine = ADP = AMP > beta,gamma-methylene ATP, while a small response or no response was induced by 2-methylthio ATP, UTP, or alpha,beta-methylene ATP. The response induced by beta,gamma-methylene ATP was completely inhibited in the ...

journal_title：Neuroscience letters

authors： Matsuoka T,Nishizaki T,Nomura T,Mori M,Okada Y

更新日期：1998-05-29 00:00:00

abstract：:The origin of sympathetic and sensory innervation of the elbow and knee joint was studied by the intra-axonal transport method. After injection of WGA-HRP into the elbow and knee joint unilaterally in adult monkeys (macaca fascicularis), labelled cells were observed ipsilaterally in both the sympathetic and dorsal roo...

journal_title：Neuroscience letters

authors： Wiberg M,Widenfalk B

更新日期：1991-06-24 00:00:00

abstract：:The sensory neurons in the trigeminal ganglion which project to the muscles of mastication of the cat were studied using the retrograde transport of horseradish peroxidase. Horseradish peroxidase either was injected directly into the masticatory muscles or applied to the nerves supplying them. Numerous retrogradely la...

journal_title：Neuroscience letters

authors： Martin JW,Panneton WM

更新日期：1986-10-20 00:00:00

abstract：:It is known that alcohol induces disorders in the metabolism of retinoids and particularly in the biosynthetic pathways of retinoic acid (RA). Since RA has, along with other hormones and particularly triiodothyronine (T3), a physiological role in the adult brain, the effect of chronic exposure to alcohol on RA and T3 ...

journal_title：Neuroscience letters

authors： Alfos S,Higueret P,Pallet V,Higueret D,Garcin H,Jaffard R

更新日期：1996-03-15 00:00:00

abstract：:It is widely held that transdiaphragmatic pressure is a reliable index of the extent of central activation of the diaphragm but the maximal voluntary transdiaphragmatic pressure is lower during inspiratory than expulsive efforts. To determine whether the diaphragm is fully activated during the two manoeuvres supramaxi...

journal_title：Neuroscience letters

authors： McKenzie DK,Plassman BL,Gandevia SC

更新日期：1988-06-17 00:00:00

abstract：:This immunohistochemical study demonstrated the presence of S-100 protein (-like substance) in the nervous systems of some invertebrate animals. The immunoreactivity of S-100 protein was detected in some neurosecretory cells, but not in glial cells in the brains (cerebral ganglia) of silkworms, cockroaches and earthwo...

journal_title：Neuroscience letters

authors： Endo Y,Endo T

更新日期：1988-07-19 00:00:00

abstract：:The neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal total biopterin were examined both in rats and mice at different time courses. Results indicate that MPTP caused a significant decrease of total biopterin content in the striatum of mice. This effect occurred as soon as 6 h after...

journal_title：Neuroscience letters

authors： Lee EH

更新日期：1988-06-07 00:00:00

abstract：:To determine whether mutations in the coding region of the alpha-synuclein gene are relevant in cases of multiple system atrophy (MSA), detailed nucleotide sequence analysis of the alpha-synuclein gene was performed using total RNA obtained from autopsied brain specimens of 11 pathologically confirmed cases of MSA. Th...

journal_title：Neuroscience letters

authors： Ozawa T,Takano H,Onodera O,Kobayashi H,Ikeuchi T,Koide R,Okuizumi K,Shimohata T,Wakabayashi K,Takahashi H,Tsuji S

更新日期：1999-07-30 00:00:00

abstract：:The role of G-proteins in the mediation of the cardiovascular effects of neuropeptide Y and the alpha 2-adrenoceptor agonist clonidine was investigated by injections of pertussis toxin (10 micrograms/30 microliters, i.v.t., 24 h) in the awake unrestrained male rat. Treatment with pertussis toxin was found to inhibit t...

journal_title：Neuroscience letters

authors： Fuxe K,von Euler G,van der Ploeg I,Fredholm BB,Agnati LF

更新日期：1989-07-03 00:00:00

abstract：:We have recently documented the presence of cholinergic neurons containing monoamine oxidase (MAO)-B activity in the striatum of C57BL/6 mouse. In the present study, we have mapped the topographical distributions of MAO-containing neurons in the mouse striatum. Positive neurons were located in the striatum of the enti...

journal_title：Neuroscience letters

authors： Nakamura S,Akiguchi I,Kimura J

更新日期：1995-01-16 00:00:00

abstract：:In the present experiment we compared differences in extracellular norepinephrine levels in vivo within the olfactory bulb of intact and castrated male rats following infusion of the norepinephrine transport inhibitors, nisoxetine and tomoxetine. With this approach it was possible to assess whether dynamic changes in ...

journal_title：Neuroscience letters

authors： Shang Y,Dluzen DE

更新日期：2002-08-09 00:00:00

abstract：:NCB-20 cells expressed m1- and m4-muscarinic acetylcholine receptor (mAChR) mRNAs, while NG108-15 cells expressed only m4-mAChR mRNA. Butyrate induced a time-dependent increase in the level of m1-mAChR mRNA with no change in the m4-mAChR mRNA level in NCB-20 cells. Similarly, butyrate did not affect the m4-mAChR mRNA ...

journal_title：Neuroscience letters

authors： Fukamauchi F,Mataga N,Wang YJ,Chuang DM

更新日期：1996-07-05 00:00:00

abstract：:Alpha-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in...

journal_title：Neuroscience letters

authors： Mishima K,Tanaka T,Pu F,Egashira N,Iwasaki K,Hidaka R,Matsunaga K,Takata J,Karube Y,Fujiwara M

更新日期：2003-01-30 00:00:00

abstract：:Reflex micturition was evoked in both non-immobilized (n = 5) and immobilized (n = 5) decerebrate cats by filling the bladder with physiological saline. Intracellular recordings were made from pudendal motoneurons (PU-MNs; n = 14) throughout the periods of before, during and after reflex micturition. The changes in th...

journal_title：Neuroscience letters

authors： Shimoda N,Takakusaki K,Nishizawa O,Tsuchida S,Mori S

更新日期：1992-02-03 00:00:00

abstract：:It was established that stimulation of the lateral hypothalamus (LH) can induce antinociception. Previous studies showed a role for the ventral tegmental area (VTA) and nucleus accumbens (NAc) in antinociception induced by LH stimulation through the orexinergic system. In this study, we tried to assess the involvement...

journal_title：Neuroscience letters

authors： Moradi M,Fatahi Z,Haghparast A

更新日期：2015-07-10 00:00:00

abstract：:Since calcium homeostasis is altered in cultured skin fibroblasts from aged and Alzheimer donors, the present study examined the degradation of spectrin, a substrate of the calcium dependent protease calpain. Spectrin proteolysis was estimated as the percentage of spectrin breakdown products (e.g., 150 + 155 kDa bands...

journal_title：Neuroscience letters

authors： Peterson C,Vanderklish P,Seubert P,Cotman C,Lynch G

更新日期：1991-01-02 00:00:00

abstract：PURPOSE:To investigate the brain protective effects of fingolimod on inflammatory response of SAH mice. METHODS:We utilized an endovascular mouse perforation model of SAH. Mice were divided into three groups: sham group, SAH group and SAH + Fingolimod group. Mice received either saline or fingolimod (1 mg/kg) intraper...

journal_title：Neuroscience letters

authors： Wang Y,Zhou S,Han Z,Yin D,Luo Y,Tian Y,Wang Z,Zhang J

更新日期：2020-09-25 00:00:00

abstract：:Spinal muscular atrophy (SMA), a primarily childhood form of motor neuron disease, is caused by reduced levels of a single, ubiquitously expressed protein: the survival motor neuron (SMN) protein. Low levels of SMN cause motor neuron degeneration but recent reports describe effects of low SMN levels in multiple tissue...

journal_title：Neuroscience letters

authors： Somers E,Riessland M,Schreml J,Wirth B,Gillingwater TH,Parson SH

更新日期：2013-06-07 00:00:00

abstract：:Dopamine (DA) neurons in the ventral tegmental area and substantia nigra pars compacta were induced to fire in bursts with application of N-methyl-D-aspartate (NMDA, 20 microM) and apamin (100 nM) while recording intracellularly in the rat brain slice. L-Arginine (300 microM), a substrate for nitric oxide (NO) product...

journal_title：Neuroscience letters

authors： Cox BA,Johnson SW

更新日期：1998-10-23 00:00:00

abstract：:Parkinson's disease (PD) is characterized by bradykinesia, resting tremor, rigidity and postural instability as well as early symptoms. Previous studies that evaluated the association between H1/H2 MAPT haplotype and PD were mostly conducted in European populations in which the H1 haplotype was a reported risk factor ...

journal_title：Neuroscience letters

authors： Miranda-Morales EG,Sandoval-Carrillo A,Castellanos-Juárez FX,Méndez-Hernández EM,La Llave-León O,Quiñones-Canales G,Ruano-Calderón LA,Arias-Carrión O,Salas-Pacheco JM

更新日期：2019-01-18 00:00:00

abstract：:It is generally assumed that the majority of substance P (SP)-containing afferents are also immunoreactive for calcitonin gene-related peptide (CGRP). In order to determine whether this is also the case in articular afferents where the contents of these peptides are low, we carried out a double labeling study using Fa...

journal_title：Neuroscience letters

authors： Tamura R,Hanesch U,Schmidt RF,Kumazawa T,Mizumura K

更新日期：1998-09-18 00:00:00

abstract：:The conductance increase induced by bath application of GABA has been measured in voltage-clamped stretch-receptor neurones of crayfish. A rapid conductance increase was obtained only at GABA concentrations above 3.3 X 10(-4) M. The response to lower GABA concentrations (between 10(-4) and 10(-6) M) developed slowly o...

journal_title：Neuroscience letters

authors： Deisz RA,Dose M,Lux HD

更新日期：1984-06-29 00:00:00

abstract：:In the present study we have used slice cultures of hippocampus and in situ hybridization techniques in order to study the ability of hippocampal neurons to synthesize CCK mRNA in the absence of extrinsic afferents. Our results show that very similar types of hippocampal neurons express CCK mRNA in culture as in situ....

journal_title：Neuroscience letters

authors： Straube A,Bender R,Otten U,Frotscher M

更新日期：1994-05-19 00:00:00

abstract：:Prolyl endopeptidase (PEP; EC 3.4.21.26) cleaves the Pro-Arg bond of arginine-vasopressin (AVP). This study investigated the effects of PEP inhibitors, 1-[1-(benzyloxycarbonyl)-L-prolyl]prolinal (Z-Pro-prolinal) and 1-[3-(2-indanylacetyl)-L-thioprolyl]pyrrolidine (Z-321), on the AVP content in the septum of rats. Oral...

journal_title：Neuroscience letters

authors： Miura N,Shibata S,Watanabe S

更新日期：1995-08-18 00:00:00