Abstract:
:The role of G-proteins in the mediation of the cardiovascular effects of neuropeptide Y and the alpha 2-adrenoceptor agonist clonidine was investigated by injections of pertussis toxin (10 micrograms/30 microliters, i.v.t., 24 h) in the awake unrestrained male rat. Treatment with pertussis toxin was found to inhibit the hypotensive and bradycardic actions of neuropeptide Y (1250 pmol) and the hypotensive actions of clonidine (1875 pmol). Control experiments showed that treatment with pertussis toxin caused an approximately 50% reduction in the back-ADP-ribosylation of GTP-binding proteins. These results suggest that G-proteins mediate the central cardiovascular actions of neuropeptide Y and clonidine.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Fuxe K,von Euler G,van der Ploeg I,Fredholm BB,Agnati LFdoi
10.1016/0304-3940(89)90556-9subject
Has Abstractpub_date
1989-07-03 00:00:00pages
337-41issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(89)90556-9journal_volume
101pub_type
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