Pertussis toxin treatment counteracts the cardiovascular effects of neuropeptide Y and clonidine in the awake unrestrained rat.

Abstract:

:The role of G-proteins in the mediation of the cardiovascular effects of neuropeptide Y and the alpha 2-adrenoceptor agonist clonidine was investigated by injections of pertussis toxin (10 micrograms/30 microliters, i.v.t., 24 h) in the awake unrestrained male rat. Treatment with pertussis toxin was found to inhibit the hypotensive and bradycardic actions of neuropeptide Y (1250 pmol) and the hypotensive actions of clonidine (1875 pmol). Control experiments showed that treatment with pertussis toxin caused an approximately 50% reduction in the back-ADP-ribosylation of GTP-binding proteins. These results suggest that G-proteins mediate the central cardiovascular actions of neuropeptide Y and clonidine.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Fuxe K,von Euler G,van der Ploeg I,Fredholm BB,Agnati LF

doi

10.1016/0304-3940(89)90556-9

subject

Has Abstract

pub_date

1989-07-03 00:00:00

pages

337-41

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(89)90556-9

journal_volume

101

pub_type

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