Increased spectrin proteolysis in fibroblasts from aged and Alzheimer donors.

abstract：:The insular cortex (IC) processes multimodal sensory information including gustatory, visceral, nociceptive, and thermal sensation, and is considered to play a role in the regulation of homeostasis. The IC receives dense histaminergic projection from the tuberomamillary nucleus in the hypothalamus, and recent studies ...

journal_title：Neuroscience letters

authors： Takei H,Song L,Ebihara K,Shirakawa T,Koshikawa N,Kobayashi M

更新日期：2012-06-14 00:00:00

abstract：:The effects of tetrahydro-9-aminoacridine (THA) on beta-adrenoceptor activation-induced synaptic potentiation were studied in brain slices of the rat amygdala using intracellular recording techniques. To exclude the involvement of N-methyl-D-aspartate (NMDA) receptors, all the experiments were performed in the presenc...

journal_title：Neuroscience letters

authors： Wang SJ,Huang CC,Hsu KS,Tsai JJ,Huang CC,Gean PW

更新日期：1996-08-23 00:00:00

abstract：:Many studies have shown that acupuncture can contribute to the biochemical balance in the central nervous system and maintenance or recovery of homeostasis. It is well known that chronic administration of ethanol may produce depletion or sensitization of extracellular dopamine levels in the nucleus accumbens. The pres...

journal_title：Neuroscience letters

authors： Zhao RJ,Yoon SS,Lee BH,Kwon YK,Kim KJ,Shim I,Choi KH,Kim MR,Golden GT,Yang CH

更新日期：2006-02-27 00:00:00

abstract：:It has recently been shown that noise can improve the detection of stimuli in several sensory modalities. We herein investigated whether visual contrast detection sensitivity can be improved by adding a certain amount of noise. The contrast detection thresholds of a light changing brightness periodically were measured...

journal_title：Neuroscience letters

authors： Sasaki H,Todorokihara M,Ishida T,Miyachi J,Kitamura T,Aoki R

更新日期：2006-11-13 00:00:00

abstract：:The nuclear factor kappa B inducing kinase gene (NIK) is located near the region of the haplotype associated with progressive supranuclear palsy (PSP) in chromosome 17q. We have analysed the coding region of the NIK gene in PSP patients through single strand conformation polymorphism and direct sequencing, in order to...

journal_title：Neuroscience letters

authors： Campdelacreu J,Ezquerra M,Muñoz E,Oliva R,Tolosa E

更新日期：2003-04-10 00:00:00

abstract：:Bath application of alpha-melanocyte stimulating hormone (alpha-MSH) to rat hypothalamic slices inhibited the spontaneous firing rate of continuously firing neurons in the ventromedial hypothalamic nucleus or paraventricular nucleus. This inhibitory effect is most likely direct and independent of synaptic transmission...

journal_title：Neuroscience letters

authors： Fong TM,Van der Ploeg LH

更新日期：2000-03-31 00:00:00

abstract：:In Creutzfeldt-Jakob disease (CJD), progressive neuronal cell death probably occurs as a result of a change in conformation of the physiological prion protein (PrP(C)). There is evidence of participation of the lymphatic system and in particular of lymphocytes in the intracorporeal transportation of the pathological p...

journal_title：Neuroscience letters

authors： Ratzka P,Döhlinger S,Cepek L,Steinacker P,Arlt S,Jacobi C,Schröter A,Wiltfang J,Prange H,Kretzschmar HA,Poser S,Otto M

更新日期：2003-05-29 00:00:00

abstract：:Both substance P (SP)- and epinephrine-containing neurons in the rostral ventrolateral medulla have been thought to play a role in regulating vasomotor tone. The combination of retrograde transport of a fluorescent dye (Fast Blue) and immunofluorescent staining for SP- and phenylethanolamine-N-methyltransferase (PNMT)...

journal_title：Neuroscience letters

authors： Lorenz RG,Saper CB,Wong DL,Ciaranello RD,Loewy AD

更新日期：1985-04-19 00:00:00

abstract：:This study aimed to determine the effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on electroencephalograms (EEGs) of rats. Fifteen Sprague-Dawley rats were subject to 100 pulses of 0.5 Hz rTMS, or sham stimulation. EEGs were recorded before stimulation and within 1 min after rTMS or sham st...

journal_title：Neuroscience letters

authors： Li L,Yin Z,Huo X

更新日期：2007-01-29 00:00:00

abstract：:It is well established that calcium-dependent neurotransmitter release and exocytosis can be regulated by altering the cholesterol content of the plasma membrane. We have compared the influence of cholesterol depletion of synaptosomal plasma membrane by 15 mM methyl-beta-cyclodextrin (MCD) treatment on calcium-depende...

journal_title：Neuroscience letters

authors： Waseem TV,Kolos VA,Lapatsina LP,Fedorovich SV

更新日期：2006-09-11 00:00:00

abstract：:The effects of two Neuropeptide Y (NPY) analogs (Y1- and Y2-type) and vasoactive intestinal peptide (VIP) on both catecholamine (adrenaline and noradrenaline) release and aldosterone production by rat adrenal capsule/glomerular zone, have been investigated in vitro. The adrenal capsule/glomerular zones, collected from...

journal_title：Neuroscience letters

authors： Bernet F,Bernard J,Laborie C,Montel V,Maubert E,Dupouy JP

更新日期：1994-01-17 00:00:00

abstract：:Cystathionine beta synthase (CBS) is the main contributor to the production of hydrogen sulfide (H2S) in the brain. Exogenously administered H2S has been reported to protect neurons against hypoxic injury, ischemia and LPS-induced neuro-inflammation and in the facilitating of long term potentiation (LTP). Dysregulatio...

journal_title：Neuroscience letters

authors： Bruintjes JJ,Henning RH,Douwenga W,van der Zee EA

更新日期：2014-03-20 00:00:00

abstract：:Although dopaminergic neurons are thought to exist in the lateral olivocochlear efferent system and modulate the afferent nerve activity, the distribution of dopamine (DA) receptor subtypes is still obscure. In the present study, we investigated the localization of five subtypes of DA receptor (D1-5) by immunocytochem...

journal_title：Neuroscience letters

authors： Inoue T,Matsubara A,Maruya S,Yamamoto Y,Namba A,Sasaki A,Shinkawa H

更新日期：2006-05-22 00:00:00

abstract：:To elucidate the metabolic process generating amyloid-beta protein (A beta) from beta-amyloid precursor protein (APP) in human brain, we partially purified secretory forms and carboxyl-terminal fragments (CTFs) of APP from the white matter of a Down's syndrome brain. We obtained secretory forms of APP which lack the e...

journal_title：Neuroscience letters

authors： Tokuda T,Tanaka K,Kametani F,Ikeda S,Yanagisawa N

更新日期：1995-02-17 00:00:00

abstract：:A procedure for dissociating viable taste cells from the rodent tongue was described. After the tongue was excised, the foliate and circumvallate papillae from the posterior region were blocked to small pieces and incubated for 2-3 h in a calcium-free salt solution containing the enzyme papain. The pieces were then tr...

journal_title：Neuroscience letters

authors： Herness MS

更新日期：1989-11-20 00:00:00

abstract：:The structural specificity of alpha-PMTX, a novel peptide toxin derived from wasp venom has been studied on the neuromuscular synapse in the walking leg of the lobster. alpha-PMTX is known to induce repetitive action potentials in the presynaptic axon due to sodium channel inactivation. We synthesized 29 analogs of al...

journal_title：Neuroscience letters

authors： Konno K,Hisada M,Naoki H,Itagaki Y,Yasuhara T,Nakata Y,Miwa A,Kawai N

更新日期：2000-05-05 00:00:00

abstract：:Temperature effects on ocular serotonin N-acetyltransferase (NAT) kinetics characteristics from Rana perezi have been studied with respect to tryptamine and serotonin as substrates. Monoamine oxidase (MAO) activity does not interfere in NAT assay at acceptoramine concentrations used in NAT kinetics characterization fr...

journal_title：Neuroscience letters

authors： Alonso-Gómez AL,Alonso-Bedate M,Delgado MJ

更新日期：1993-05-28 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA, 500 ng/0.5 microliters), alpha-amino-3-hydroxy-5-methyl-4-isoxasole-propionic acid (AMPA, 1000 ng/0.5 microliters), or kainic acid (50 ng/0.5 microliters) injected into intermediate and caudal parts of the caudate-putamen induced contralateral head turns and rotations. Picrotoxin (250 ng/0....

journal_title：Neuroscience letters

authors： Ossowska K

更新日期：1995-12-29 00:00:00

abstract：:Although metabolic syndrome (MS) is recognized as a risk factor for ischemic stroke, little is known about genetic variants that confer susceptibility to ischemic stroke among individuals with or without MS. This study was completed to investigate whether the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorp...

journal_title：Neuroscience letters

authors： Kim OJ,Hong SH,Jeon YJ,Oh SH,Kim HS,Park YS,Kim EJ,Kim NK

更新日期：2013-01-15 00:00:00

abstract：:A paired-pulse stimulus protocol was used to measure angular bundle to dentate gyrus paired-pulse inhibition in rats before and after the occurrence of 36 or 72 seizures elicited from the contralateral CA3 region. The seizures showed progressive lengthening. There was a moderate increase in paired-pulse depression 1 h...

journal_title：Neuroscience letters

authors： Stringer JL,Lothman EW

更新日期：1989-10-23 00:00:00

abstract：:We reported previously that administration of 1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphorylcholine (ODHPC), a kind of phosphatidylcholine, enhanced discriminatory shock avoidance learning in rats. Since long-term potentiation (LTP) of the hippocampus has been suggested to be a physiological substrate of some form...

journal_title：Neuroscience letters

authors： Izaki Y,Hashimoto M,Arita J

更新日期：1999-01-29 00:00:00

abstract：:The analgesic effect of kappa partial agonist opioids (i.e. nalbuphine, pentazocine and butorphanol) is significantly greater in women. Recent evidence suggests that this sexual dimorphism may result from a naloxone-sensitive anti-analgesic effect that is activated along with, and summates with, the analgesic effect o...

journal_title：Neuroscience letters

authors： Gear RW,Gordon NC,Miaskowski C,Paul SM,Heller PH,Levine JD

更新日期：2003-11-06 00:00:00

abstract：:We examined the effect of intraventricular injection of nerve growth factor (NGF) on the choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) mRNA expression in the septa of neonatal rats. Rat pups were injected with 2.5 S NGF or cytochrome-c (control) on postnatal days (PN) 4 and 18, and s...

journal_title：Neuroscience letters

authors： Tian X,Sun X,Suszkiw JB

更新日期：1996-05-10 00:00:00

abstract：:The role of the serotonergic system in regulating the expression of estrogen receptor (ER) α in the hypothalamus was investigated in ovariectomized rats by injecting a serotonin synthesis inhibitor, parachlorophenylalanine (PCPA), or by destroying the dorsal raphe nucleus (DR). The number of ERα-immunoreactive (ir) ce...

journal_title：Neuroscience letters

authors： Ito H,Shimogawa Y,Kohagura D,Moriizumi T,Yamanouchi K

更新日期：2014-11-07 00:00:00

abstract：:Human monocytes and a variety of tissue macrophages, including microglia, were studied immunohistochemically to determine the expression of a novel microglial marker, human glucose transporter 5 (hGLUT5), in these cells. The hGLUT5 was not expressed in most peripheral macrophages in the normal state, but weakly expres...

journal_title：Neuroscience letters

authors： Sasaki A,Horikoshi Y,Yokoo H,Nakazato Y,Yamaguchi H

更新日期：2003-02-20 00:00:00

abstract：:Glucose metabolism and tricarboxylic acid cycle (TCA) kinetics have been shown to decline in brain with age in various animal species. This study examined TCA cycle kinetics and age in Brown-Norway Fischer 344 rats. Using [1-(13)C]glucose infused over 10, 30, 60 or 100 min, and following the label through the TCA cycl...

journal_title：Neuroscience letters

authors： Perron JT,Tyson RL,Sutherland GR

更新日期：2000-03-10 00:00:00

abstract：:We investigated the mRNA expression of the various complement components in cultured mouse microglia and astrocytes by the reverse transcription and polymerase chain reaction. C1q, C2, C3, and C4 mRNAs were detected in microglial cultures. C3 and C4 mRNAs were found in astrocyte cultures. Microglia showed enhanced exp...

journal_title：Neuroscience letters

authors： Haga S,Aizawa T,Ishii T,Ikeda K

更新日期：1996-10-04 00:00:00

abstract：:In the present experiment we compared differences in extracellular norepinephrine levels in vivo within the olfactory bulb of intact and castrated male rats following infusion of the norepinephrine transport inhibitors, nisoxetine and tomoxetine. With this approach it was possible to assess whether dynamic changes in ...

journal_title：Neuroscience letters

authors： Shang Y,Dluzen DE

更新日期：2002-08-09 00:00:00

abstract：:Interstitial cells of Cajal (ICCs) play a key role in regulating gastrointestinal tract motility. The pathophysiological basis of colonic aperistalsis in Hirschsprung's disease (HD) is still not fully understood. Many studies reported that decreased numbers or disrupted networks of ICCs were associated with HD. Little...

journal_title：Neuroscience letters

authors： Wang H,Zhang Y,Liu W,Wu R,Chen X,Gu L,Wei B,Gao Y

更新日期：2009-02-27 00:00:00

abstract：:The effect of apamin on learning was examined using two behavioral tasks where the animals were subjected to two trials separated by a 24h interval. In the Y maze task, apamin administered before the acquisition session did not enhance performance on both the acquisition session and the restitution session. In the sec...

journal_title：Neuroscience letters

authors： Deschaux O,Bizot JC

更新日期：2005-09-23 00:00:00