Abstract:
:Although dopaminergic neurons are thought to exist in the lateral olivocochlear efferent system and modulate the afferent nerve activity, the distribution of dopamine (DA) receptor subtypes is still obscure. In the present study, we investigated the localization of five subtypes of DA receptor (D1-5) by immunocytochemical analysis and the gene expression of D1-5 using RT-PCR procedure in the rat cochlea. Most, but not all, spiral ganglion neurons were immunolabeled with all the anti-DA receptor subunit antibodies and faint punctuate immunoreactivities were observed in inner hair cell regions. Gene expression for all receptors was detected. These results suggest that all DA receptor subtypes are present in spiral ganglion cells, and potentially regulate afferent neurotransmission.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Inoue T,Matsubara A,Maruya S,Yamamoto Y,Namba A,Sasaki A,Shinkawa Hdoi
10.1016/j.neulet.2006.01.063keywords:
subject
Has Abstractpub_date
2006-05-22 00:00:00pages
226-9issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(06)00113-3journal_volume
399pub_type
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