Abstract:
:The action of some cholinergic drugs has been studied on the field potentials evoked by orthodromic stimulation of the lateral olfactory tract (LOT) in guinea-pig olfactory cortex slices maintained in vitro. A reversible depression of the electrically evoked surface-negative field potential (N-wave) was seen following superfusion of muscarine (10-200 microM) or mixed-agonist choline esters but not nicotinic agonists. This depression was blocked by atropine and pirenzepine, but not d-tubocurarine or by antagonists active at gamma-aminobutyric acid or adenosine receptors. Little effect of muscarinic agonists was observed on the compound action potential recorded from the LOT, or on pial surface DC potential. A possible presynaptic site of action of muscarinic agonists in the olfactory cortex is discussed.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Williams SH,Constanti A,Brown DAdoi
10.1016/0304-3940(85)90259-9subject
Has Abstractpub_date
1985-05-23 00:00:00pages
301-6issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(85)90259-9journal_volume
56pub_type
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