Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation.

abstract：:The binding of the lectin soybean agglutinin (SBA) to the olfactory system of both the rat and mouse was investigated histochemically. SBA bound to fibers in the accessory olfactory nerve and to glomeruli in the accessory olfactory bulb. In addition, SBA binding sites were present in some, but not all, glomeruli in th...

journal_title：Neuroscience letters

authors： Key B,Giorgi PP

更新日期：1986-08-29 00:00:00

abstract：:In recent years, several attempts have been made to identify biochemical and/or genetic markers which might have diagnostic and prognostic uses for Alzheimer's disease (AD). To look for possible new blood markers, a longitudinal study was carried out in our Central Nervous System Biomedical Research Center between Oct...

journal_title：Neuroscience letters

authors： Lombardi VR,Cacabelos R

更新日期：1999-01-22 00:00:00

abstract：:The synapsin III gene, SYN3, which belongs to the family of synaptic vesicle-associated proteins, has been implicated in the modulation of neurotransmitter release and in synaptogenesis, suggesting a potential role in several neuropsychiatric diseases. The human SYN3 gene is located on chromosome 22q12-13, a candidate...

journal_title：Neuroscience letters

authors： Chen Q,Che R,Wang X,O'Neill FA,Walsh D,Tang W,Shi Y,He L,Kendler KS,Chen X

更新日期：2009-11-20 00:00:00

abstract：:The effect of the metabotropic glutamate receptor (mGluR) antagonist (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) was investigated on the induction of long-term potentiation (LTP) of alpha-amino-3-hydroxy-5- methyl-4-isoxazoleproprionate receptor-mediated excitatory postsynaptic currents (epscs) recorded from denta...

journal_title：Neuroscience letters

authors： Wang Y,Rowan MJ,Anwyl R

更新日期：1995-09-15 00:00:00

abstract：:The CHRNA7 gene encoding the α7 nicotinic acetylcholine receptor (nAChR) has repeatedly been linked with schizophrenia and the P50 sensory gating deficit. The α7 nAChR is considered a promising drug target for treatment of cognitive dysfunction in schizophrenia and improves memory and executive functions in patients a...

journal_title：Neuroscience letters

authors： Dyrvig M,Mikkelsen JD,Lichota J

更新日期：2019-06-21 00:00:00

abstract：:Tumor cells frequently express the insulin-like growth factor I (IGF-I). Recently we demonstrated that rat glioma cells when transfected with a vector encoding antisense IGF-I cDNA lost tumorigenicity and induced a tumor specific immune response involving CD8+ lymphocytes. Here we show that the cultured transfected ce...

journal_title：Neuroscience letters

authors： Trojan J,Duc HT,Upegui-Gonzalez LC,Hor F,Guo Y,Anthony D,Ilan J

更新日期：1996-07-05 00:00:00

abstract：:We have previously demonstrated that differences in neuropathic pain-like behaviors after sciatic nerve injury genetically maps to the major histocompatibility complex (MHC) in rats carrying RT1(c) or RT1(av1) haplotypes on the Piebald Virol Glaxo (PVG) background. In order to further explore the genetic contribution ...

journal_title：Neuroscience letters

authors： Dominguez CA,Li L,Lidman O,Olsson T,Wiesenfeld-Hallin Z,Piehl F,Xu XJ

更新日期：2008-09-19 00:00:00

abstract：:Vasopressin (VP) is a peptide consisting of 9 amino acids which acts as a neurotransmitter or neuromodulator in the central nervous system. Neurons containing VP project to some nuclei in the hypothalamus that have a role in energy metabolism. To clarify the possible role of VP on glucose metabolism in the brain, we e...

journal_title：Neuroscience letters

authors： Nagai N,Nagai K,Takezawa K,Chun SJ,Nakagawa H

更新日期：1995-05-12 00:00:00

abstract：:The pedunculopontine tegmental nucleus (PPTg) contains cholinergic neurons whose principal ascending connections are with thalamic nuclei and structures associated with the striatum. It has been hypothesized that PPTg neurons are more closely associated with the substantia nigra (and therefore striatal motor systems) ...

journal_title：Neuroscience letters

authors： Jenkins TA,Latimer MP,Alderson HL,Winn P

更新日期：2002-03-29 00:00:00

abstract：:The pattern of projection of the ventrobasal thalamic complex (VB) upon the neocortical barrel field of normal and reeler mutant mice was determined by orthograde degeneration experiments and by Timm's histochemical method. In both reeler and normal mice the thalamic terminals are concentrated at the midcortical zone ...

journal_title：Neuroscience letters

authors： Caviness VS Jr,Frost DO,Hayes NL

更新日期：1976-09-01 00:00:00

abstract：BACKROUND:A relatively small number of genetic variants are implicated to pathophysiology of intracerebral hemorrhage (ICH). Aquaporin-4 (AQP4) has been reported to be implicated in the pathophysiological processes of ICH development. OBJECTIVE:To examine the role of AQP4 gene region polymorphisms on the ICH risk. ME...

journal_title：Neuroscience letters

authors： Dardiotis E,Siokas V,Marogianni C,Aloizou AM,Sokratous M,Paterakis K,Dardioti M,Grigoriadis S,Brotis A,Kapsalaki E,Fountas K,Jagiella J,Hadjigeorgiou GM

更新日期：2019-03-23 00:00:00

abstract：:Depression is one of the most prevalent challenges of mental conditions. Yet its exact etiology has not been clear. Chronic stress increases the production of cytokines, which can lead to depression. Hepcidin, an iron modulator, is involved in the inflammation process as well as iron homeostasis. This study was design...

journal_title：Neuroscience letters

authors： Farajdokht F,Soleimani M,Mehrpouya S,Barati M,Nahavandi A

更新日期：2015-02-19 00:00:00

abstract：:The structure of CACNA1G, the gene encoding alpha1G, a human brain T Ca2+ channel alpha1 subunit, was determined by comparison of polymerase chain reaction-amplified brain cDNA and genomic sequences. The gene consists of at least 38 exons, two of them newly-identified, spanning at least 66490 basepairs of chromosome 1...

journal_title：Neuroscience letters

authors： Mittman S,Guo J,Agnew WS

更新日期：1999-10-29 00:00:00

abstract：:Different transcription elements have been proposed to play a role in the regulation of acetylcholinesterase (AChE) in muscle and neuron, and cyclic adenosine 3',5'-monophosphate (cAMP)-dependent pathway is one of them. In order to test the possible role of cAMP in regulating the expression of human AChE, an approxima...

journal_title：Neuroscience letters

authors： Wan DC,Choi RC,Siow NL,Tsim KW

更新日期：2000-07-07 00:00:00

abstract：:A calcium-dependent potassium channel K(Ca) has been isolated in mouse motoneurons. With physiological concentrations of potassium across inside-out patches, a 100 pS K(Ca) channel was activated when the bath solution of Ca2+ was in excess of 1 microM. Introduction of the drug tedisamil, a blocker of repolarizing pota...

journal_title：Neuroscience letters

authors： McLarnon JG,Sawyer D,Michikawa M,Kim SU

更新日期：1992-09-14 00:00:00

abstract：:Leucine-enkephalin-like immunoreactive (ENK-LI) afferent fibers to the feline homologue of the Onuf's nucleus (pudendal motoneurons) originate mainly from lamina X of the sacral cord. They make synaptic contacts chiefly upon dendrites of pudendal motoneurons; the synaptic terminals most often contain pleomorphic synap...

journal_title：Neuroscience letters

authors： Konishi A,Itoh K,Sugimoto T,Yasui Y,Kaneko T,Takada M,Mizuno N

更新日期：1985-10-24 00:00:00

abstract：:Acetylcholine, synthesized in the cytoplasm of cholinergic neurons by choline acetyltransferase (ChAT), is packaged in synaptic vesicles by vesicular acetylcholine transporter (VAChT). The entire VAChT gene has been reported to be located within the first intron of the ChAT gene. In order to examine whether or not ChA...

journal_title：Neuroscience letters

authors： Matsuura J,Ajiki K,Ichikawa T,Misawa H

更新日期：1997-10-31 00:00:00

abstract：:The human visual system is divided into two pathways specialized for the processing of either objects or spatial locations. Neuroanatomical studies in monkeys have suggested that a similar specialization may also divide auditory cortex into two such pathways. We used the identical stimulus material in two experimental...

journal_title：Neuroscience letters

authors： Herrmann CS,Senkowski D,Maess B,Friederici AD

更新日期：2002-12-06 00:00:00

abstract：:The accumulation of alpha-synuclein, ubiquitin and other proteins in Lewy bodies in degenerating dopaminergic neurones in substantia nigra in idiopathic Parkinson's disease (PD) suggest that inhibition of normal/abnormal protein degradation may contribute to neuronal death. We now show for the first time that the chym...

journal_title：Neuroscience letters

authors： McNaught KS,Jenner P

更新日期：2001-01-19 00:00:00

abstract：:We evaluated the effect of cabergoline on superoxide anion production by rat microglial cells using a 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1, 2-a]pyrazin-3-one-dependent chemiluminescence assay. Cabergoline dose-dependently inhibited superoxide anion production by microglial cells stimulated with phorbol my...

journal_title：Neuroscience letters

authors： Yoshida T,Tanaka M,Suzuki Y,Sohmiya M,Okamoto K

更新日期：2002-09-13 00:00:00

abstract：:The Flinders Sensitive Line rats showed an increased immobility response by 104% (P<0.01) in the forced swim test with respect to the Flinders Resistant Line rats (control). The Flinders Sensitive Line rats also had an increase of [(125)I]galanin (porcine) binding in the dorsal raphe (55+/-3.3 fmol/mg protein) with re...

journal_title：Neuroscience letters

authors： Bellido I,Díaz-Cabiale Z,Jiménez-Vasquez PA,Andbjer B,Mathé AA,Fuxe K

更新日期：2002-01-11 00:00:00

abstract：:The sulphur-containing acidic amino acids (SAAs) display neuroexcitatory actions similar to those of L-glutamate and are widely regarded as bona fide transmitter candidates. In this study, L-cysteine sulphinic acid, L-cysteic acid, DL-homocysteic acid and L-homocysteine sulphinic acid were investigated for their abili...

journal_title：Neuroscience letters

authors： Porter RH,Roberts PJ

更新日期：1993-05-14 00:00:00

abstract：:Mammalian neurons express the neural intermediate filament protein neurofilament (NF). In the retina, NFs have been detected primarily in the axons and processes of retinal ganglion and horizontal cells. We found an amacrine cell type that was immunolabeled with an antibody against SMI32, a non-phosphorylated epitope ...

journal_title：Neuroscience letters

authors： Lim EJ,Kim IB,Oh SJ,Chun MH

更新日期：2007-09-13 00:00:00

abstract：:The roles played by glycine- and glutamate-mediated synaptic transmission in the generation of 5-hydroxytryptamine (5-HT)-induced rhythmic activity were examined in isolated spinal cord preparations from fetal rats. Bath application of 5-HT (0.1-30 microM) evoked rhythmic activity in lumbar ventral roots at and after ...

journal_title：Neuroscience letters

authors： Nakayama K,Nishimaru H,Kudo N

更新日期：2001-07-06 00:00:00

abstract：:Rat dorsal root ganglion neurons can be classified into at least three distinct groups based on cell size, afferent fiber diameter, electrophysiological properties, sensitivity to vanilloid agonists such as capsaicin, and function. In the present study, ATP-activated current in these neurons was characterized using wh...

journal_title：Neuroscience letters

authors： Li C,Peoples RW,Lanthorn TH,Li ZW,Weight FF

更新日期：1999-03-19 00:00:00

abstract：:Neural stem cell (NSC) transplantation has exhibited considerable therapeutic potential in spinal cord injury. However, most experiments in animals have been performed by injecting these cells directly into the injured spinal cord. A cardinal feature of NSCs is their exceptional migratory ability through the nervous s...

journal_title：Neuroscience letters

authors： Takeuchi H,Natsume A,Wakabayashi T,Aoshima C,Shimato S,Ito M,Ishii J,Maeda Y,Hara M,Kim SU,Yoshida J

更新日期：2007-10-16 00:00:00

abstract：:Immunohistochemical fluorescent double labeling revealed the coexistence of galanin and substance P in nerve fibers in the mouse nasal mucosa. At the base of and in the epithelium, all galanin fibers also contained substance P, but around the blood vessels and glands, most of them did not. Since substance P fibers in ...

journal_title：Neuroscience letters

authors： Matsuda H,Tsukuda M,Kadota T,Kusunoki T,Kishida R

更新日期：1994-05-23 00:00:00

abstract：:Several clinical and epidemiological studies suggest that Alzheimer's disease (AD) and vascular dementia share common risk factors. Oxidative stress is one of these well recognized factors. It can result from an excess of free-radical activity and impaired antioxidant defenses. Paraoxonase (PON1), a component of high ...

journal_title：Neuroscience letters

authors： Helbecque N,Cottel D,Codron V,Berr C,Amouyel P

更新日期：2004-03-18 00:00:00

abstract：:The amino acid content of Torpedo synaptosomes was investigated. It was found that glutamate and taurine were particularly enriched, their concentration exceeding that of acetylcholine by 50-60%. Other amino acids such as alanine, gamma-aminobutyric acid (GABA), glycine, leucine and phenylalanine were also present, bu...

journal_title：Neuroscience letters

authors： Vyas S,Bradford HF

更新日期：1987-11-10 00:00:00

abstract：:In a random number generation (RNG) task subjects are instructed to generate the numbers 1-10 in a random fashion. RNG performance is assumed to involve executive functions, as it requires controlled response generation and suppression of habitual responses. To investigate cerebral structures involved in RNG associate...

journal_title：Neuroscience letters

authors： Daniels C,Witt K,Wolff S,Jansen O,Deuschl G

更新日期：2003-07-10 00:00:00