Abstract:
:Several clinical and epidemiological studies suggest that Alzheimer's disease (AD) and vascular dementia share common risk factors. Oxidative stress is one of these well recognized factors. It can result from an excess of free-radical activity and impaired antioxidant defenses. Paraoxonase (PON1), a component of high density lipoproteins, has antioxidative potential and was previously associated with an increased risk of cardiovascular diseases. The impact of two polymorphisms in PON1 (Gln192Arg associated with enzyme activity and T-107C associated with enzyme concentration) was examined in a case-control study. The two polymorphisms were independent risk factors for nonAD dementia, particularly in APOE-4 noncarriers. An at-'risk haplotype' could be constructed including the Gln192 and the T-107 alleles, suggesting that subjects at risk have lower plasma paraoxonase levels and this enzyme is less active.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Helbecque N,Cottel D,Codron V,Berr C,Amouyel Pdoi
10.1016/j.neulet.2003.12.100keywords:
subject
Has Abstractpub_date
2004-03-18 00:00:00pages
41-4issue
1eissn
0304-3940issn
1872-7972pii
S0304394004000254journal_volume
358pub_type
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