Paraoxonase 1 gene polymorphisms and dementia in humans.

Abstract:

:Several clinical and epidemiological studies suggest that Alzheimer's disease (AD) and vascular dementia share common risk factors. Oxidative stress is one of these well recognized factors. It can result from an excess of free-radical activity and impaired antioxidant defenses. Paraoxonase (PON1), a component of high density lipoproteins, has antioxidative potential and was previously associated with an increased risk of cardiovascular diseases. The impact of two polymorphisms in PON1 (Gln192Arg associated with enzyme activity and T-107C associated with enzyme concentration) was examined in a case-control study. The two polymorphisms were independent risk factors for nonAD dementia, particularly in APOE-4 noncarriers. An at-'risk haplotype' could be constructed including the Gln192 and the T-107 alleles, suggesting that subjects at risk have lower plasma paraoxonase levels and this enzyme is less active.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Helbecque N,Cottel D,Codron V,Berr C,Amouyel P

doi

10.1016/j.neulet.2003.12.100

keywords:

subject

Has Abstract

pub_date

2004-03-18 00:00:00

pages

41-4

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304394004000254

journal_volume

358

pub_type

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